Navigation Links
Inner workings of a cellular nanomotor revealed
Date:2/5/2014

Our cells produce thousands of proteins but more than one-third of these proteins can fulfill their function only after migrating to the outside of the cell. While it is known that protein migration occurs with the help of various 'nanomotors' that push proteins out of the cell, little is known about their precise mechanical functioning. New research by Anastassios Economou (KU Leuven) and his team reveals the inner workings of one such nanomotor, called SecA, with new clarity.

Protein migration is a fundamental problem in biology and is essential for life. Examples of migrating proteins include insulin (the absence of which leads to diabetes), antibodies (essential for combating infections), membrane channels (essential for neuronal cell function) and toxin-proteins (secreted by pathogenic microorganisms).

Migrating proteins contain chemical signals called signal peptides. These signal peptides act as postal addresses and direct exported proteins to the membrane for transport outside the cell.

In previous research, Dr Economou, in collaboration with Babis Kalodimos (Rutgers University), revealed how signal peptides bind to a specific cellular receptor on the membrane, which subsequently connects to the export channel leading out of the cell. This receptor was also found to act as a nanomotor, with two separate piston-like mechanical parts that somehow push proteins out of the cell. The exact mechanism by which this occurred remained a mystery. Until now.

In the current study, published in the December issue of Molecular Cell, Economou and his team show how the SecA receptor moves to push proteins out of the cell: when a signal peptide makes contact, the two pistons become excited. They position themselves one against the other in a series of defined steps and modify their shape. This finely orchestrated series of motions opens the export channel and traps the exported protein inside it. In a final step, the two
'/>"/>

Contact: Professor Tassos Economou
tassos.economou@rega.kuleuven.be
32-163-79273
KU Leuven
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Biophysical Society announces winners of 2014 Minority Affairs Committee Travel Awards
2. Biophysical Society announces winners of 2014 CPOW Travel Awards
3. Nobel winners for discoveries on cellular vesicle transport speak out at ASCB in New Orleans
4. Inventions that improve lives are winners at the 2013 Newark Innovation Acceleration Challenge
5. AIBS announces winners of Faces of Biology photo competition
6. NERC announces the winner of its first photo and essay competition
7. Winners named in 2013 AAAS Kavli Science Journalism Awards competition
8. AVS Announces Its Major Award Winners of 2013
9. Dinner rituals that correlate with child and adult BMI
10. DOE rooftop challenge winners offer energy, cost savings
11. AnaptysBio Named a 2013 "Fierce 15" Winner
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inner workings of a cellular nanomotor revealed
(Date:8/1/2014)... 10,000 reptile species have been recorded into the ... reptile species and classification, making the reptile species ... world, alongside bird and fish species. , For ... mark the year that reptiles would become the ... include snakes, lizards, turtles, crocodiles, tuataras and amphisbaenians. ...
(Date:8/1/2014)... of the UC Davis Center for Neuroscience and ... Science and Engineering Faculty Fellowship from the U.S. ... will support new work on learning and memory ... , The new project aims to connect neural ... in the cortex and hippocampus, brain regions that ...
(Date:8/1/2014)... of marine mammals have officially named a species ... Sousa sahulensis , according to the Wildlife Conservation ... describing the newly named species is the culmination ... available historical records, physical descriptions, and genetic data ... ranging from the coast of West Africa to ...
Breaking Biology News(10 mins):Reptile Database surpasses 10,000 reptile species 2Reptile Database surpasses 10,000 reptile species 3Scientists name new species of cetacean: The Australian humpback dolphin 2Scientists name new species of cetacean: The Australian humpback dolphin 3
... African Americans are four to five times more likely to ... kidney failure have an increased risk of developing kidney failure, ... skewed risk between races. Previous studies identified variants in a ... gene creates a protein that is a component of HDL, ...
... innovative analysis of how social media can affect the ... by a scientist at Penn State University studying attitudes ... of biology, studied how users of Twitter -- a ... about a new vaccine. He then tracked how the ...
... Now computers are at it again, but this ... itself. An interdisciplinary team of scientists at Vanderbilt ... taken a major step toward this goal by demonstrating ... a biological system and derive the basic mathematical equations ...
Cached Biology News:Better ways to predict kidney disease risk for African Americans 2Better ways to predict kidney disease risk for African Americans 3Twitter data used to track vaccination rates and attitudes 2Twitter data used to track vaccination rates and attitudes 3Twitter data used to track vaccination rates and attitudes 4Robot biologist solves complex problem from scratch 2Robot biologist solves complex problem from scratch 3
(Date:8/1/2014)... 2014 Applied DNA Sciences, Inc. ... anti-counterfeiting technology and product authentication solutions, will host a ... its fiscal third quarter results. The Quarterly Report on ... the end of the day on Monday August 11, ... host a conference call beginning at 9:00 A.M. Eastern ...
(Date:8/1/2014)... , Aug. 1. 2014 As one of ... 2014 AACC Annual Meeting & Clinical Lab Expo is ... patient care are introduced to the healthcare world. This ... Expo,s 650 exhibitors will include the latest diagnostic technology ... Advances in smartphones and biosensors have enabled the development ...
(Date:8/1/2014)... , August 1, 2014 According ... Research "Biophotonics Market - Global Industry Analysis, Size, Share, ... was valued at USD 25.16 billion in 2013, which ... growing at a CAGR of 10.4% from 2014 to ... at  http://www.transparencymarketresearch.com/biophotonics-market.html Increasing demand for accurate ...
(Date:8/1/2014)... Aug. 1, 2014 Cambrex Corporation (NYSE: ... 30, 2014. Highlights , Second ... in the same period last year. , Second quarter ... in the same period last year (see table at the ... guidance increased, excluding the impact of foreign currency, to between ...
Breaking Biology Technology:Applied DNA Sciences to Host Conference Call Tuesday August 12, 2014 2Applied DNA Sciences to Host Conference Call Tuesday August 12, 2014 3Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 2Lab-on-a-Chip Technology to Be Featured at 2014 AACC Annual Meeting & Clinical Lab Expo 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 2Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 3Global Biophotonics Market is Expected to Reach USD 50.20 Billion in 2020: Transparency Market Research 4Cambrex Reports Second Quarter 2014 Financial Results 2Cambrex Reports Second Quarter 2014 Financial Results 3Cambrex Reports Second Quarter 2014 Financial Results 4Cambrex Reports Second Quarter 2014 Financial Results 5Cambrex Reports Second Quarter 2014 Financial Results 6Cambrex Reports Second Quarter 2014 Financial Results 7Cambrex Reports Second Quarter 2014 Financial Results 8Cambrex Reports Second Quarter 2014 Financial Results 9Cambrex Reports Second Quarter 2014 Financial Results 10Cambrex Reports Second Quarter 2014 Financial Results 11Cambrex Reports Second Quarter 2014 Financial Results 12Cambrex Reports Second Quarter 2014 Financial Results 13Cambrex Reports Second Quarter 2014 Financial Results 14Cambrex Reports Second Quarter 2014 Financial Results 15Cambrex Reports Second Quarter 2014 Financial Results 16
... Medical Technology. Inc.,has been awarded a five-year contract ... VHA Inc. and the University HealthSystem,Consortium (UHC), two ... The agreement makes Liftaem(TM) available to more ... "By using proper equipment such,as Liftaem(TM), hospitals not ...
... 12 VIA Pharmaceuticals,(Nasdaq: VIAP ), ... of,compounds for the treatment of cardiovascular disease, ... board. Joining the clinical advisory,board,s chair, Marc ... Medical School, and Senior Physician, Brigham & ...
... Breakthrough Pain Associated with Chronic Pain Conditions in ... ... Around-the-Clock, FRAZER, Pa., Nov. 12 Cephalon, Inc. (Nasdaq:,CEPH) ... the U.S. Food and Drug Administration (FDA) seeking approval to,market FENTORA(R) ...
Cached Biology Technology:Smart Medical Technology, Inc. Awarded Novation Contract for Ground-breaking Liftaem(TM) System that Aids Lifting and Transferring Patients 2VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 2VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 3VIA Pharmaceuticals Expands Clinical Advisory Board With Leading Experts in Cardiovascular Disease 4Cephalon Submits Supplemental New Drug Application for FENTORA 2Cephalon Submits Supplemental New Drug Application for FENTORA 3Cephalon Submits Supplemental New Drug Application for FENTORA 4Cephalon Submits Supplemental New Drug Application for FENTORA 5Cephalon Submits Supplemental New Drug Application for FENTORA 6Cephalon Submits Supplemental New Drug Application for FENTORA 7
... a platform for fully automated systems for ... easily be configured for applications ranging from ... allows closed loop screening, which means it ... generating, cherry picking and follow up studies ...
... Vivaclear centrifugal filters are disposable microfiltration devices for ... in the range 100 l to 500 l. ... accepting 2.2 ml centrifuge tubes. Product Features: ... size Low hold up volume ( ...
... The Caliper Prelude Workstation fully ... as solvent addition, extraction, sample transfer, ... on-line HPLC, and UV detection. The ... compliance with 21 CFR Part 11. ...
... Use in any standard fixed-angle microcentrifuge ... g.,Spin- centrifuge tube filters consist ... a centrifuge tube. They filter by ... HPLC sample preparation, removal of cells ...
Biology Products: