Navigation Links
Inner workings of a cellular nanomotor revealed
Date:2/5/2014

Our cells produce thousands of proteins but more than one-third of these proteins can fulfill their function only after migrating to the outside of the cell. While it is known that protein migration occurs with the help of various 'nanomotors' that push proteins out of the cell, little is known about their precise mechanical functioning. New research by Anastassios Economou (KU Leuven) and his team reveals the inner workings of one such nanomotor, called SecA, with new clarity.

Protein migration is a fundamental problem in biology and is essential for life. Examples of migrating proteins include insulin (the absence of which leads to diabetes), antibodies (essential for combating infections), membrane channels (essential for neuronal cell function) and toxin-proteins (secreted by pathogenic microorganisms).

Migrating proteins contain chemical signals called signal peptides. These signal peptides act as postal addresses and direct exported proteins to the membrane for transport outside the cell.

In previous research, Dr Economou, in collaboration with Babis Kalodimos (Rutgers University), revealed how signal peptides bind to a specific cellular receptor on the membrane, which subsequently connects to the export channel leading out of the cell. This receptor was also found to act as a nanomotor, with two separate piston-like mechanical parts that somehow push proteins out of the cell. The exact mechanism by which this occurred remained a mystery. Until now.

In the current study, published in the December issue of Molecular Cell, Economou and his team show how the SecA receptor moves to push proteins out of the cell: when a signal peptide makes contact, the two pistons become excited. They position themselves one against the other in a series of defined steps and modify their shape. This finely orchestrated series of motions opens the export channel and traps the exported protein inside it. In a final step, the two
'/>"/>

Contact: Professor Tassos Economou
tassos.economou@rega.kuleuven.be
32-163-79273
KU Leuven
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Biophysical Society announces winners of 2014 Minority Affairs Committee Travel Awards
2. Biophysical Society announces winners of 2014 CPOW Travel Awards
3. Nobel winners for discoveries on cellular vesicle transport speak out at ASCB in New Orleans
4. Inventions that improve lives are winners at the 2013 Newark Innovation Acceleration Challenge
5. AIBS announces winners of Faces of Biology photo competition
6. NERC announces the winner of its first photo and essay competition
7. Winners named in 2013 AAAS Kavli Science Journalism Awards competition
8. AVS Announces Its Major Award Winners of 2013
9. Dinner rituals that correlate with child and adult BMI
10. DOE rooftop challenge winners offer energy, cost savings
11. AnaptysBio Named a 2013 "Fierce 15" Winner
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inner workings of a cellular nanomotor revealed
(Date:3/24/2015)... , March 24, 2015   Crossmatch ... solutions, today announced that its U.are.U ® ... retailer Goorin Bros . to achieve PCI ... solution secures access to the POS terminal, protecting ... risk of data breaches. With ...
(Date:3/20/2015)... --Research and Markets ( http://www.researchandmarkets.com/research/4stcg3/india_sensors ) ... Sensors Market Forecast and Opportunities 2020" report ... is projected to grow at a CAGR over ... industrial and healthcare sectors are the key application ... adoption of MEMS technology in sensors is growing ...
(Date:3/18/2015)... , March 18, 2015 As ... businesses, new revolutionary smart wallets and apps continue to be ... currently entrenched in the mobile payment industry in focus today ... Holding Ltd. (NYSE: BABA ), Apple Inc. (NASDAQ: ... ) and Facebook Inc. (NASDAQ: FB ) ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 2India Sensors Market Forecast and Opportunities 2020 - STMicroelectronics held the largest share in 2014 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 2Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 3Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 4Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 5Revolutionary Smart Wallet & Mobile Payment Choices Change the Game for Consumers - Company Begins Shipping Newest Digital Wallet to Customers 6
... become embedded in genomic DNA, which contains the complete ... for cells. It is known that ribonucleotides in DNA ... genomic instability and altered DNA metabolism, but not much ... A new study provides a mechanistic explanation of how ...
... MD -- The Biophysical Society has announced the ... to attend the Biophysical Society,s 56th Annual Meeting ... Diego, California, February 25-29, 2012. The purpose of ... interaction between American biophysicists and scientists working in ...
... can lead to climate change adaptation practices in ... "Climate-smart agriculture has the potential to increase sustainable ... climate impacts and mitigate climate change through greenhouse ... Neufeldt the lead expert on climate change at ...
Cached Biology News:Study identifies mechanisms cells use to remove bits of RNA from DNA strands 2Biophysical Society Announces winners of 2012 International Relations Committee travel awards 2Biophysical Society Announces winners of 2012 International Relations Committee travel awards 3Biophysical Society Announces winners of 2012 International Relations Committee travel awards 4Climate-smart agriculture should be livelihood-smart too 2Climate-smart agriculture should be livelihood-smart too 3
(Date:4/20/2015)... 2015   Meditope Biosciences, Inc ., a biotechnology ... today announced presentation of data demonstrating the use of ... conjugates (ADCs). The data were presented in an abstract at ... in Philadelphia . ... to the many commercial applications that may be possible ...
(Date:4/18/2015)... PHILADELPHIA , April 18, 2015 ... (NASDAQ: CRIS ) will be presenting data ... the American Associate of Cancer Research Annual Meeting ... ).      (Logo: http://photos.prnewswire.com/prnh/20130418/608115 ) ... its proprietary Nicotinamide phosphoribosyltransferase (NAMPT) small molecule inhibitors ...
(Date:4/17/2015)... 2015 CIO Review ( http://www.cioreview.com ) ... Most Promising Pharma and Life Science Technology Solution Providers ... compliance software platform for life sciences companies. , ... panel of experts and members of CIO Review’s editorial ... Platform has been on our radar for some time ...
(Date:4/17/2015)... 17, 2015  US-Australian drug discovery company, Novogen, today ... Understanding with the Feinstein Institute for Medical Research ... to collaborate with the objective of developing ... collaboration brings together the drug discovery expertise of ... the Feinstein Institute in neurosciences and oncology. ...
Breaking Biology Technology:Meditope Biosciences Presents Data At The American Association Of Cancer Research (AACR) Annual Meeting Validating Its SnAP Technology Platform 2Aurigene to Present its NAMPT and IRAK-4 Inhibitors Programs at AACR 2015 2MMIS Chosen by CIO Review as Top 20 Most Promising Pharma and Life Science Technology Solution Providers 2015 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 2Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 3Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 4Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 5Novogen and Feinstein Institute Join Forces to Find Effective Treatments for Brain Cancer 6
... 3 Catalyst,Pharmaceutical Partners, Inc. (Nasdaq: CPRX ... and commercializes prescription,drugs for the treatment of drug ... J. McEnany, Chief Executive,Officer, will be presenting an ... 10th Annual Global Investment Conference on Tuesday, November ...
... - Oncolytics Biotech Inc. (TSX:,ONC, NASDAQ: ONCY) announced ... its U.K. combination REOLYSIN(R) and docetaxel clinical trial,for ... of the Royal Surrey Hospital, U.K., presented the,results ... Cancer,(iSBTC) annual meeting on November 1, 2008. The ...
... AEterna Zentaris Inc.,(NASDAQ: AEZS ; TSX: AEZ), ... oncology, today reported that it has entered the,second ... trial in endometrial,cancer with AEZS-108, a luteinizing hormone-releasing ... enter the second stage of,patient recruitment was taken ...
Cached Biology Technology:Catalyst Pharmaceutical Partners to Present at the Rodman & Renshaw 10th Annual Global Investment Conference 2Oncolytics Biotech Inc. Collaborators Present Positive Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 2Oncolytics Biotech Inc. Collaborators Present Positive Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 3Oncolytics Biotech Inc. Collaborators Present Positive Combination REOLYSIN(R) and Docetaxel Results at iSBTc Annual Meeting 4AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108 2AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108 3AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108 4AEterna Zentaris Reaches 2nd Stage of Patient Recruitment for Phase 2 Trial in Endometrial Cancer with the Innovative LHRH Receptor Targeted Conjugate, AEZS-108 5
... are designed for sequencing inserts cloned into ... or T3 RNA polymerase promoters, or lambda ... at a concentration of 0.1 µg/µl in ... DNA sequencing reactions using SequiTherm™ EXCEL™ II ...
BD BioCoat Matrigel Matrix 35 mm Culture Dishes Coating : BD MatrigelTM Basement Membrane Matrix ,Surface : ECM/attachment factors ,Surface area : 9.6 cm2 ,Dim nominal : 35 mm x 10 mm ,Vo...
BD BioCoat Collagen I 35 mm Culture Dishes, tissue-culture treated polystyrene with a uniform application of rat tail collagen type I....
... with AutoGen AutoGenesys, BioRobotics BioPick, BioGrid, TAS ... picking systems This CLS number is a ... Cornings product number. If showing no availability ... number (D9314) or contact customer service for ...
Biology Products: