Navigation Links
Innate immunity system of sheep and goat herds against viral infections clarified
Date:4/26/2013

Biology and Biochemistry graduate, Paula Juregui Onieva, has undertaken research for her PhD thesis on the factors of restriction of innate immunity present in sheep and goats. In concrete, she investigated if these factors had antiviral activity so that, pending further studies, they could be used in preventing certain diseases of these animals, such as mastitis, arthritis, pneumonia and/or encephalitis. The thesis is titled Inmunidad innata frente a lentivirus de pequeos rumiantes (SRLV): Papel de TRIM5 (Innate immunity against small ruminant lentivirus (SRLV): the role of TRIM5).

The PhD thesis deals with innate immunity against lentivirus in small ruminants. Lentivirus is a genus of viruses that produces slow infections, deteriorates the immune system and causes various pathologies. For example, in sheep, the Visna Maedi virus gives rise to nervous and brain diseases while the Maedi virus causes respiratory problems. Lentivirus in small ruminants makes up a highly heterogeneous, including also the caprine arthritis/encephalitis virus.

According to Ms Juregui, "currently there do not exist vaccinations or efficacious treatment for these types of infections, and so the study on the factors of restriction of innate immunity could be an effective alternative for treating or preventing these infections". The factors of restriction studied involve antiviral proteins present in certain cells which inhibit the viral cycle. The research focused on the factor known as TRIM5 which, apparently, prevents the virus managing to incorporate itself into the genome of the cell, thus impeding infection.

With the aim of finding out how this factor of restriction functions, the researcher had a four-fold objective for her PhD thesis: identifying and characterising TRIM5 in sheep and goat species; determining a possible restrictive role played by the lentivirus infection; exploring the restriction of the infection by heterologous retrovirus; and investigating, through phylogenetic analysis, the on-going trends and a possible co-evolution between lentivirus and TRIM5 in domestic and wild ruminants.


'/>"/>

Contact: Oihane Lakar Iraizoz
o.lakar@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. UTSW researchers identify new enzyme that acts as innate immunity sensor
2. Innate immune system protein provides a new target in war against bacterial infections
3. Pitt team finds immunity protein that ramps up inflammation, and agents that can block it
4. Circuitry of cells involved in immunity, autoimmune diseases exposed
5. Behind closed doors: Researchers show how probiotics boost plant immunity
6. Flu immunity is affected by how many viruses actually cause the infection
7. Drive-Up Biometric System from SRI International Sarnoff Wins New Product Showcase Award at ISC West 2013
8. EyeLock Debuts Its New HBOX Iris Authentication System at ISC West
9. Tiny grazers play key role in marine ecosystem health
10. Nothing fishy about it: Fish oil can boost the immune system
11. How herpesvirus invades nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/5/2017)... , April 5, 2017  The Allen Institute ... Allen Cell Explorer: a one-of-a-kind portal and dynamic digital ... 3D imaging data, the first application of deep learning ... human stem cell lines and a growing suite of ... platform for these and future publicly available resources created ...
(Date:3/30/2017)... ANGELES , March 30, 2017  On April ... Hack the Genome hackathon at Microsoft,s ... exciting two-day competition will focus on developing health and ... Hack the Genome is the ... been tremendous. The world,s largest companies in the genomics, ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... (PRWEB) , ... April 27, 2017 , ... ... and Migraine Therapeutics Summit ( http://www.paintherapeuticsummit.com ) is coming to San Diego, CA ... attend this conference to learn about the latest advances in the treatment of ...
(Date:4/27/2017)... ... April 27, 2017 , ... The Council for Agricultural Science ... Jayson Lusk, a consummate communicator who promotes agricultural science and technology in the ... he explains how innovation and growth in agriculture are critical for food security ...
(Date:4/26/2017)... (PRWEB) , ... April 26, 2017 , ... ... FDA’s GMP expectations for phase I clinical trials comes to Tampa, San Francisco ... biotechnology and pharma professionals representing FDA regulated organizations such as Pfizer Inc., Teva ...
(Date:4/26/2017)...  Genisphere LLC, provider of the 3DNA ® ... and sponsored research agreement with the University of ... overall goal of the partnership is to study ... and formulations after in vivo administration. ... as well as inflammatory responses, demonstrating various methods ...
Breaking Biology Technology: