Navigation Links
Innate immunity system of sheep and goat herds against viral infections clarified
Date:4/26/2013

Biology and Biochemistry graduate, Paula Juregui Onieva, has undertaken research for her PhD thesis on the factors of restriction of innate immunity present in sheep and goats. In concrete, she investigated if these factors had antiviral activity so that, pending further studies, they could be used in preventing certain diseases of these animals, such as mastitis, arthritis, pneumonia and/or encephalitis. The thesis is titled Inmunidad innata frente a lentivirus de pequeos rumiantes (SRLV): Papel de TRIM5 (Innate immunity against small ruminant lentivirus (SRLV): the role of TRIM5).

The PhD thesis deals with innate immunity against lentivirus in small ruminants. Lentivirus is a genus of viruses that produces slow infections, deteriorates the immune system and causes various pathologies. For example, in sheep, the Visna Maedi virus gives rise to nervous and brain diseases while the Maedi virus causes respiratory problems. Lentivirus in small ruminants makes up a highly heterogeneous, including also the caprine arthritis/encephalitis virus.

According to Ms Juregui, "currently there do not exist vaccinations or efficacious treatment for these types of infections, and so the study on the factors of restriction of innate immunity could be an effective alternative for treating or preventing these infections". The factors of restriction studied involve antiviral proteins present in certain cells which inhibit the viral cycle. The research focused on the factor known as TRIM5 which, apparently, prevents the virus managing to incorporate itself into the genome of the cell, thus impeding infection.

With the aim of finding out how this factor of restriction functions, the researcher had a four-fold objective for her PhD thesis: identifying and characterising TRIM5 in sheep and goat species; determining a possible restrictive role played by the lentivirus infection; exploring the restriction of the infection by heterologous retrovirus; and investigating, through phylogenetic analysis, the on-going trends and a possible co-evolution between lentivirus and TRIM5 in domestic and wild ruminants.


'/>"/>

Contact: Oihane Lakar Iraizoz
o.lakar@elhuyar.com
34-943-363-040
Elhuyar Fundazioa
Source:Eurekalert

Related biology news :

1. UTSW researchers identify new enzyme that acts as innate immunity sensor
2. Innate immune system protein provides a new target in war against bacterial infections
3. Pitt team finds immunity protein that ramps up inflammation, and agents that can block it
4. Circuitry of cells involved in immunity, autoimmune diseases exposed
5. Behind closed doors: Researchers show how probiotics boost plant immunity
6. Flu immunity is affected by how many viruses actually cause the infection
7. Drive-Up Biometric System from SRI International Sarnoff Wins New Product Showcase Award at ISC West 2013
8. EyeLock Debuts Its New HBOX Iris Authentication System at ISC West
9. Tiny grazers play key role in marine ecosystem health
10. Nothing fishy about it: Fish oil can boost the immune system
11. How herpesvirus invades nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... WASHINGTON , June 22, 2016 On ... highly-anticipated call to industry to share solutions for the ... by U.S. Customs and Border Protection (CBP), explains that ... nationals are departing the United States ... criminals, and to defeat imposters. Logo - ...
(Date:6/9/2016)... 9, 2016  Perkotek an innovation leader in attendance control systems is proud to ... hours, for employers to make sure the right employees are actually signing in, and ... ... ... ...
(Date:6/2/2016)... June 2, 2016   The Weather Company , an ... Ads, an industry-first capability in which consumers will be able ... to ask questions via voice or text and receive relevant ... Marketers have long sought an advertising solution ... can be personal, relevant and valuable; and can scale across ...
Breaking Biology News(10 mins):
(Date:12/2/2016)... ... December 01, 2016 , ... ... findings demonstrating the value of DNA microarray comparative genomic hybridization (array CGH) ... Antonio Breast Cancer Symposium. Using molecular test results from tumors with previously ...
(Date:12/2/2016)... , ... December 01, 2016 , ... The Conference Forum ... to three days and will take place on February 1-3, 2017 at the Roosevelt ... James Gulley (NCI), the program provides a unique 360-degree approach, which addresses the most ...
(Date:12/2/2016)... ... December 02, 2016 , ... ... dedicated to collaboratively developing improved chemistry, manufacturing and control technologies for the ... UHPLC, with robust, probe-based sampling. , Online liquid chromatography analysis is ...
(Date:12/2/2016)... The immunohistochemistry (IHC) market is projected to reach ... during the forecast period of 2016 to 2021 dominated by immunohistochemistry ... the largest share of immunohistochemistry (IHC) market, by end user.   ... , , ... across 225 pages, profiling 10 companies and supported with 181 tables ...
Breaking Biology Technology: