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Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms
Date:5/23/2011

to the mechanisms that learn and develop new immune responses to infections over time.

The PGRP proteins are normally expressed in phagocytic cells in blood and on body surface areas such as skin, mouth, intestine and other tissues that have direct or indirect contact with the external world, Dziarski noted. In some tissues it appears that the PGRPs help maintain a healthy relationship between the body and certain beneficial bacteria. Some studies have indicated that the loss of the PGRP proteins may lead to inflammatory bowel disease, suggesting that the research reported Monday could point the way to new approaches to target such problems, Dziarski said.


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Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

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