Navigation Links
Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms
Date:5/23/2011

GARY, Ind. A group of proteins that act as the body's built-in line of defense against invading bacteria use a molecular trick to induce bacteria to destroy themselves, researchers at the Indiana University School of Medicine have determined. The research could point the way toward new anti-bacterial treatments that could take on bacteria that are resistant to antibiotics.

The proteins, called Peptidoglycan Recognition Proteins (PGRPs), are able to detect and target bacteria because bacteria are unique in having peptidoglycan polymers in their cellular walls. However, the mechanism by which PGRPs are able to kill bacteria had not been determined.

A research team led by Roman Dziarski, Ph.D., professor of microbiology and immunology at Indiana University School of Medicine Northwest, reported May 22 in the advance online edition of the journal Nature Medicine that the PGRPs are able to induce a suicide response in the targeted bacteria.

The PGRPs accomplish the mission by binding to specific sites in bacterial cell walls in ways that exploit a bacterial defense mechanism known as protein-sensing two-component systems. These systems, which normally enable the bacteria to detect and eject malformed proteins, interpret the PGRPs as just such malformed proteins. Unable to dislodge the PGRPs, the bacteria then activate a suicide response, the researchers said.

This approach is different than those employed by other anti-bacterial mechanisms, such as the immune system's white blood cells, said Dziarski.

"This could be a target to develop new anti-bacterial applications," Dziarski said.

Dziarski and colleague Dipika Gupta, Ph.D., associate professor of biochemistry and molecular biology at Indiana University School of Medicine Northwest, first cloned the PGRP genes in 2001. The PGRP genes, which are found in species ranging from insects to mammals, are part of the body's innate immune system, in contrast
'/>"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. A new player in the innate immunity game?
2. New discovery suggests our lungs are innately prone to silicosis and related diseases
3. New research shows how disease-causing parasite gets around human innate immunity
4. Papillomavirus silences innate immune response
5. Brain innately separates living and non-living objects for processing
6. NIH funds $9.5 million for research on HIV and the human innate immune system
7. Facial expressions of emotion are innate, not learned, says new study
8. Genetic finding implicates innate immune system in major cause of blindness
9. Understanding a bacterial immune system 1 step at a time
10. Study finds therapies using induced pluripotent stem cells could encounter immune rejection problems
11. For puzzling childhood immune disorder, gene research opens door to first diagnostic test
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms
(Date:8/28/2014)... significant health risk to people with asthma according to a ... Clinical Immunology . , By critically reviewing the findings from ... that the presence of several types of mould can lead ... the likelihood of developing the condition. , The research has ... Medical School and is the first time all of the ...
(Date:8/28/2014)... California, and Alaska totaled 515 million board feet in ... of more than 10 percent compared to the first ... Research Station reported today. During this same period, West ... million board feet. , The total value of these ... $390 million in the same quarter, while the total ...
(Date:8/28/2014)... Ludwig-Maximilians-Universitaet (LMU) in Munich have assigned a number ... predatory arthropods. These animals lived in shallow marine ... forms found in Jurassic strata. , Before ... marine habitat and were fossilized some 435 million ... of the Silurian seas although they were ...
Breaking Biology News(10 mins):Indoor mold poses health risk to asthma sufferers 2West coast log exports up, lumber exports down in second quarter of 2014 2Paleontology: Oldest representative of a weird arthropod group 2
... become after being exposed to a specialized electrical field ... or a stage of cancer already invading other parts ... electrical process and found cells that expanded the most ... has spread beyond its point of origin. The technique ...
... German . Within the last few years ... has been increased considerably. A worthwhile effort as, after ... and safe methods of transport checks are offered by terahertz ... however, it has to be measured quantitatively, so that damage ...
... the worlds of law, geography, economics, public health ... College London) on Friday September 19th to examine ... locally-rooted champions for global sustainability, reaching out to ... change. The symposium, which is called: "The Sustainable ...
Cached Biology News:Expanding cell girth indicates seriousness of breast cancer 2Checking people at airports -- with terahertz radiation 2Universities develop a more sustainable future 2
(Date:8/28/2014)... Vt. (PRWEB) August 28, 2014 ... testing around the world is available from Strategic ... diagnostics companies. “ Industrial Microbiology Market Review, Fourth ... Industrial Market ” (IMMR—4) tracks and compares microbiology ... in North America, Europe and Asia, and forecasts ...
(Date:8/28/2014)... Supplementing their complete line of ... Eppendorf Safe Lock Centrifuge Tubes . This ... quality tubes at an affordable price. Eppendorf Safe ... chemical, medical, pharmaceutical, and life science research and ... able to afford Eppendorf products. , Eppendorf is ...
(Date:8/27/2014)... 27, 2014 Green & Grow Inc. ... B funding and secured Otter Capital as a significant ... accelerate commercialization of GGI’s Agriplier™ technology, building on recent ... , “Since our first meeting, we have been impressed ... product space,” said Alan Sobba, President and CEO of ...
(Date:8/27/2014)... , Aug. 27, 2014 Reportlinker.com ... is available in its catalogue: ... http://www.reportlinker.com/p02316661/Global-Biodegradable-Packaging-Materials-Market-2014-2018.html ... materials that are readily decomposed by the ... conventional non-degradable packaging in terms of raw ...
Breaking Biology Technology:2 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 22 Billion Industrial Microbiology Tests Conducted for Product Quality and Safety Worldwide 3Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 2Eppendorf Safe Lock Centrifuge Tube Promotion Now Available at Major Pipette Distributor Pipette.com 3Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 2Green & Grow Inc. Secures $6M Series B Funding from Otter Capital 3Global Biodegradable Packaging Materials Market 2014-2018 2Global Biodegradable Packaging Materials Market 2014-2018 3Global Biodegradable Packaging Materials Market 2014-2018 4Global Biodegradable Packaging Materials Market 2014-2018 5Global Biodegradable Packaging Materials Market 2014-2018 6Global Biodegradable Packaging Materials Market 2014-2018 7
... Pa. , Aug. 2 Tengion Inc. (Nasdaq: ... Brian Davis to the position of Chief Financial Officer.  Mr. Davis ... company using enzymatic technologies to develop improved protein therapeutics. At its peak, ... three sites.  , , , ...
... 15,000 of them. A Northwestern University research team ... with tiny beams of light using an innovative nanofabrication ... new method, which could do for nanofabrication what the ... will be published Aug. 1 by the journal ...
...  The European Commission announced that it has granted import, ... developed by DuPont (NYSE: ... AgroSciences LLC , a wholly owned subsidiary of   The ... insect protection and the Herculex® RW trait stack (also known ...
Cached Biology Technology:Tengion Appoints A. Brian Davis Chief Financial Officer 215,000 beams of light 215,000 beams of light 3European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 2European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 3European Union Approves Maize with Herculex® I/Herculex® RW and Herculex® RW/ Herculex® I/Roundup Ready® Corn 2 Trait Stacks for Import, Food, Feed & Processing 4
"BioTracker 6X Bromophenol Blue Tracking Dye is composed of 60% St DI H2O, 30% Glycerol, 10% 10XTE, 0.25% BPB Dye and 0.85% SDS....
Request Info...
Agarose, low melting/gelling temperature, high MW separation (>1000 bp), 25 g. Suitable for enzymatic modifications. Nuclease-free.Gel point: 24-30 C, EEO (-mr): 300 gm/cm2. Category: Nucleotides &...
Request Info...
Biology Products: