Navigation Links
Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms
Date:5/23/2011

GARY, Ind. A group of proteins that act as the body's built-in line of defense against invading bacteria use a molecular trick to induce bacteria to destroy themselves, researchers at the Indiana University School of Medicine have determined. The research could point the way toward new anti-bacterial treatments that could take on bacteria that are resistant to antibiotics.

The proteins, called Peptidoglycan Recognition Proteins (PGRPs), are able to detect and target bacteria because bacteria are unique in having peptidoglycan polymers in their cellular walls. However, the mechanism by which PGRPs are able to kill bacteria had not been determined.

A research team led by Roman Dziarski, Ph.D., professor of microbiology and immunology at Indiana University School of Medicine Northwest, reported May 22 in the advance online edition of the journal Nature Medicine that the PGRPs are able to induce a suicide response in the targeted bacteria.

The PGRPs accomplish the mission by binding to specific sites in bacterial cell walls in ways that exploit a bacterial defense mechanism known as protein-sensing two-component systems. These systems, which normally enable the bacteria to detect and eject malformed proteins, interpret the PGRPs as just such malformed proteins. Unable to dislodge the PGRPs, the bacteria then activate a suicide response, the researchers said.

This approach is different than those employed by other anti-bacterial mechanisms, such as the immune system's white blood cells, said Dziarski.

"This could be a target to develop new anti-bacterial applications," Dziarski said.

Dziarski and colleague Dipika Gupta, Ph.D., associate professor of biochemistry and molecular biology at Indiana University School of Medicine Northwest, first cloned the PGRP genes in 2001. The PGRP genes, which are found in species ranging from insects to mammals, are part of the body's innate immune system, in contrast
'/>"/>

Contact: Eric Schoch
eschoch@iupui.edu
317-274-7722
Indiana University School of Medicine
Source:Eurekalert  

Page: 1 2

Related biology news :

1. A new player in the innate immunity game?
2. New discovery suggests our lungs are innately prone to silicosis and related diseases
3. New research shows how disease-causing parasite gets around human innate immunity
4. Papillomavirus silences innate immune response
5. Brain innately separates living and non-living objects for processing
6. NIH funds $9.5 million for research on HIV and the human innate immune system
7. Facial expressions of emotion are innate, not learned, says new study
8. Genetic finding implicates innate immune system in major cause of blindness
9. Understanding a bacterial immune system 1 step at a time
10. Study finds therapies using induced pluripotent stem cells could encounter immune rejection problems
11. For puzzling childhood immune disorder, gene research opens door to first diagnostic test
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Innate immune system proteins attack bacteria by triggering bacterial suicide mechanisms
(Date:4/20/2015)... 2015 Huntington Memorial Hospital is the first ... new miniaturized, wireless monitoring sensor to manage heart failure ... only FDA-approved heart failure monitoring device that has been ... physicians to manage heart failure. The CardioMEMS ... the pulmonary artery (PA) during a non-surgical procedure to ...
(Date:4/14/2015)... YORK , April 14, 2015  HYPR ... IDentity Online (FIDO ® ) Alliance tm , ... specifications. FIDO members commit to share technology and ... methods that are interoperable, more secure and private, ... enable biometric identity verification that protects sensitive user ...
(Date:4/13/2015)... , April 13, 2015  higi, a leading ... ways to more fully engage with their communities around ... industry-leading, privacy protected and secure API.  ... enables the most accessible, affordable, and convenient vehicle to ... The API will allow ...
Breaking Biology News(10 mins):Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 2Huntington Memorial Hospital Becomes First in the San Gabriel Valley to Offer Patients a New Heart Failure Monitoring Solution 3HYPR Corp. Joins the FIDO Alliance 2HYPR Corp. Joins the FIDO Alliance 3higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 2higi Launches Seamless Access to HIPAA-Compliant Health Outcomes and Activity Data 3
... A new analysis of extinct sea creatures suggests that the ... that allowed these ancient species to adapt to and thrive ... this week in the journal Nature by scientists ... report that the evolution of live-born young depended crucially on ...
... some individuals in the vegetative and minimally conscious states, ... learn and thereby demonstrate at least a partial consciousness. ... online edition of Nature Neuroscience . It ... patients in vegetative and minimally conscious states can learn. ...
... first drink may influence genes linked to alcoholism, making the ... team of researchers, led by scientists at Washington University School ... Australia. They wanted to learn whether twins who start drinking ... more heritable form of alcohol dependence than those who begin ...
Cached Biology News:Genetic sex determination let ancient species adapt to ocean life 2Scientists find that individuals in vegetative states can learn 2Young age at first drink may affect genes and risk for alcoholism 2Young age at first drink may affect genes and risk for alcoholism 3
(Date:4/23/2015)... CA (PRWEB) April 23, 2015 Delpor, ... today announced that the United States Patent and Trademark ... Company’s NANOPOR™ technology. US Pat. No. ... Delpor’s microfabricated drug delivery device for the ... proprietary NANOPOR™ technology for the sustained (zero-order) release of ...
(Date:4/22/2015)... , April 22, 2015 /PRNewswire/ - BioAmber Inc. (NYSE and EURONEXT Paris:BIOA) today ... first quarter 2015 on Thursday, May 7, 2015 after ... a webcast and conference call for 4.30 pm ET ... Live audio of the conference call will be ... investors, members of the news media and the general ...
(Date:4/22/2015)... Calif. , April 22, 2015 ... and analytics, announced today that it has opened ... its continued growth and expansion.  The common stock ... Act, Section 506(c), a law intended to encourage ... regulations.  Prior to 506(c), small businesses largely relied ...
(Date:4/22/2015)... 2015 /PRNewswire/ - Portage Biotech Inc. ("Portage") (OTC Market: ... announce that Biohaven Pharmaceutical Holding Company Limited (Biohaven), ... to initiate a Phase 1 pharmacokinetic and biomarker ... Biohaven plans to initiate the trial no later ... in the Phase 1 study, Biohaven will move ...
Breaking Biology Technology:Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 2Delpor, Inc. Announces the Issuance of 2 New US Patents Based on its Nanopore Technology which Enables the Sustained Release of Drugs from a Small Implant Device 3BioAmber Announces Webcast of Fiscal First Quarter 2015 Financial Results 2Steep Hill Launches $5M Limited Stock Offering 2Steep Hill Launches $5M Limited Stock Offering 3Portage's Biohaven to begin Phase 1 study in 3Q2015 and readying for Phase 3 study start by 1Q2016 2Portage's Biohaven to begin Phase 1 study in 3Q2015 and readying for Phase 3 study start by 1Q2016 3
... SHENYANG, China, Aug. 20 /Xinhua-PRNewswire-FirstCall/ -- 3SBio ... biotechnology company focused on,researching, developing, manufacturing and ... Annual General Meeting of,Shareholders of 3SBio Inc. ... (Friday) at,10:00 a.m. (Beijing time) at No.3 ...
... Medication Management Systems,(MMS) today announced a new ... -- the result of a legislative initiative ... benefit for North,Dakota state employees and other ... Care System(TM) will provide North Dakota,pharmacists with ...
... Aug. 20 Pressure,BioSciences, Inc. (Nasdaq: PBIO ... for sale of ProteoSolve-SB, a novel, pressure cycling,technology ... of nucleic acids (DNA and RNA), proteins, and,lipids ... laboratory research.,This patent-pending kit was released earlier this ...
Cached Biology Technology:3SBio Inc. to Hold Annual General Meeting 2North Dakota Pharmacists and Medication Management Systems Partner to Deliver Quality MTM Services to Patients With Diabetes 2Pressure BioSciences, Inc. Releases Novel, PCT-dependent Sample Preparation Kit for Systems Biology Studies 2Pressure BioSciences, Inc. Releases Novel, PCT-dependent Sample Preparation Kit for Systems Biology Studies 3Pressure BioSciences, Inc. Releases Novel, PCT-dependent Sample Preparation Kit for Systems Biology Studies 4