Navigation Links
Innate immune system protein provides a new target in war against bacterial infections
Date:7/2/2012

Research led by St. Jude Children's Research Hospital scientists has identified a possible new approach to defeating bacterial infections by targeting an innate immune system component in a bid to invigorate the immune response.

In this study, researchers demonstrated that the primary function of one of the innate immune molecules is to suppress inflammation, which in turn dampens the immune response to infections and other threats. Investigators showed the protein works by inhibiting two pathways that control production of specialized molecules that fight infections. The findings appear in the current online edition of the scientific journal Nature.

"The beauty of this finding is that if we can generate monoclonal neutralizing antibodies against this protein, we can block bacterial infection. This discovery offers a completely new approach to fighting infections by targeting the host immune response rather than the bacterium," said Thirumala-Devi Kanneganti, Ph.D., an associate member of the St. Jude Department of Immunology, and the study's senior and corresponding author. Monoclonal antibodies are laboratory-produced versions of natural antibodies and are designed to detect specific proteins. Kanneganti laboratory is already working to develop a neutralizing antibody.

Despite the availability of antibiotics, bacterial infections continue to extract a heavy toll of suffering and death. A better understanding of how the immune system recognizes and responds to infectious agents would aid efforts to develop new, more effective treatments.

This study builds on earlier work from Kanneganti's laboratory and focuses on the NOD-like receptor protein 6 (NLRP6). NLRP6 belongs to a family of proteins that are part of the innate immune response that serves as the first line of defense. These proteins serve as sentinels working inside cells to recognize and response to infectious agents. Until now, however, nothing was known ab
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
2. Preventing the immune system from going haywire during sepsis
3. Programmable DNA scissors found for bacterial immune system
4. UGA study reveals flu-fighting role for well-known immune component
5. London researchers discover novel mechanism involved in key immune response
6. Mystery to the origin of long-lived, skin-deep immune cells uncovered
7. Breast-fed babies gut microbes contribute to healthy immune systems
8. New screening technique yields elusive compounds to block immune-regulating enzyme
9. Immune-response genes affecting breast tumor eradication
10. Carnegie Mellon fluorescent biosensor reveals mechanism critical to immune system amplification
11. New genetic mechanism of immune deficiency discovered
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... 2014The development of stem cell therapies to cure a ... stem cell populations based on cell surface markers. Researchers ... marker that is highly expressed in a type of ... they describe in an article in BioResearch Open ... Inc., publishers. The article is available free on the ...
(Date:4/17/2014)... suggests that fish consumption advisories for expecting mothers ... contaminants like persistent organic pollutants (POPs). , ... including University of Toronto Scarborough PhD student Matt ... different levels of environmental contamination, a mother,s compliance ... the body influenced exposure in her children. , ...
(Date:4/17/2014)... credit-card-sized anthrax detection cartridge developed at Sandia National Laboratories ... safer, easier, faster and cheaper. , Bacillus ... found in soils all over the world and can ... and animals. The bacteria can survive in harsh conditions ... may occur through skin contact, inhalation of spores ...
Breaking Biology News(10 mins):Fish consumption advisories fail to cover all types of contaminants 2Pocket-sized anthrax detector aids global agriculture 2Pocket-sized anthrax detector aids global agriculture 3
... are part of an international team that has used DNA ... history of North America,s woolly mammoths and ancient horses. ... professor Duane Froese and his colleagues counters an important extinction ... analysis concluded that more than half of the large mammals ...
... FAIRBANKS, AlaskaScientists have identified a novel antifreeze molecule ... below minus 100 degrees Fahrenheit. Unlike all previously described ... xylomannan, has little or no protein. It is composed ... exist in new places within the cells of organisms. ...
... or for Tasmanian devils biting each other on ... to extinction through the transmission of a protozoan parasite. ... detective work, of David Varricchio and colleagues published in PLoS ... was to blame for the diseased jaw bones seen in ...
Cached Biology News:Scientists isolate new antifreeze molecule in Alaska beetle 2
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s resolutions ... care of my furry companion." Nowadays there are pet salons, dog ... to take the little canine or feline darlings along wherever mommy ... some pricey toys at the pet store. But anyone who has ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management ... Product Strategy. In this role, Michelle will work with current ... in the development of iLab products. Her main goal will ... to the scientific community by offering the most advanced, user-friendly, ...
(Date:1/14/2014)... 14, 2014   Kinaxis ®, provider of RapidResponse ®, ... and operations planning ( S&OP ) service, is proud to ... which will be held at the Hilton San Diego Bayfront, ... customer Elisabeth Kaszas , Director of Supply Chain at ...
(Date:1/14/2014)... 2014 Independent publisher Bitingduck Press, with ... Canada, has big ideas for 2014 in production and ... are to produce high-quality, low-cost, DRM-free ebooks and to ... , The first major development will be bookstore ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... (ABI) (OTCBB: AMAR) today provided an update on company activities. ... Nearing CompletionABI,s oral interferon research continues. Results from a Phase ... relapse in hepatitis C patients are expected in the first ... in combination with Tamiflu, for the treatment of influenza infection ...
... VEGA BIOFUELS, INC. (Pink Sheets: VGPR ) provides ... In my last Update, I mentioned that we were working ... has caused problems for our shareholders that use Penson and Alpine ... been working to resolve this matter. We have been ...
... HONG KONG, Oct. 14, 2011 /PRNewswire-Asia-FirstCall/ -- China Cord Blood ... the first and largest cord blood banking operator in China, today ... shareholders at its Hong Kong office at 48/F, Bank of China ... Kong Time on December 19, 2011 (8:00 a.m. U.S. Eastern Time ...
Cached Biology Technology:Amarillo Biosciences Issues Corporate Update 2Vega Biofuels Provides Update to Shareholders 2China Cord Blood Corporation to Hold Annual General Meeting in Hong Kong on December 19, 2011 2
... High pH, Concentrated x 10 This ... target retrievel prior to immunohistochemical staining procedures. ... tissue sections mounted on glass slides. For ... 9.9, is especially effective. It should be ...
... off-white solid. Increases the expression of glutathione peroxidase. ... H 2 O. Unstable in aqueous solutions; ... CAS 3211-76-5, M.W. 196.1. References: Merck ... Junod, A.F. 1995. Biochem. J. ...
... UN-SCAN-IT gel Software converts any scanner into ... numerous options and features, the basic operation ... JPEG, PCX, BMP, etc.) into pixel density ... steps. Turn your scanner ...
The BioLogic Maximizer mixer is for use with the Maximizer valve system. The mixer improves gradient quality by mixing the output of the BioLogic DuoFlow workstation pumps....
Biology Products: