Navigation Links
Injectable gel could spell relief for arthritis sufferers
Date:4/13/2011

y, they discovered a GRAS material that could be coaxed into self-assembling into a drug-containing gel. "The beauty of self-assembly is that whatever exists in solution during the assembly process--in this case, a drug--becomes entrapped," says Vemula, first author of the paper, who also has an appointment at HST.

They further expected that the same material would disassemble, releasing its drug payload, when exposed to the enzymes present during inflammations like those associated with arthritis.

Promising Results

A series of experiments confirmed this. For example, the team created a gel containing a dye as a stand-in for a drug, then exposed it to enzymes associated with arthritis. The drug was released. Further, the addition of agents that inhibited the enzymes stopped the release, indicating that the gel "can release encapsulated agents in an on-demand manner," the researchers write. Although the team has yet to test this in humans, they did find that dye was also released in response to synovial fluid taken from arthritic human joints.

Among other promising results, the researchers found that gel injected into the healthy joints of mice remained stable for at least two months. Further, the gel withstood wear and tear representative of conditions in a moving joint.

Additional tests in mice are underway. The technique has yet to be demonstrated in humans, but the researchers write that it "should have broad implications for the localized treatment of manydiseases" caused by the enzymatic destruction of tissues.

The researchers have applied for a patent on the work, which was sponsored by the Center for Integration of Medicine and Innovative Technology (CIMIT) through the U.S. Army and by the Harvard Catalyst Program.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UTMB study identifies women at risk of gaining excessive weight with injectable birth control
2. Vitiligo skin disorder could yield clues in fight against melanoma
3. Saliva proteins could help detection of oral cancer
4. Research about plant viruses could lead to new ways to improve crop yields
5. Nanodiamond drug device could transform cancer treatment
6. UNC study on properties of carbon nanotubes, water could have wide-ranging implications
7. So-called sandfish could help materials handling and process technology specialists
8. Discovery of natural compounds that could slow blood vessel growth
9. Researchers design artificial cells that could power medical implants
10. Herbicide-resistant grape could revitalize Midwest wine industry
11. Sensitive laser instrument could aid search for life on Mars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/24/2015)... This report analyzes the worldwide markets for Iris ... for the US, Canada , ... Asia-Pacific , Middle East , and ... are provided for the period 2013 through 2020. Also, a ... and analytics are derived from primary and secondary research. Company ...
(Date:2/18/2015)... , Feb. 18, 2015  Cepheid (NASDAQ: ... at the following conferences, and invited investors to participate via ... Boston, MA Tuesday, March 3, 2015 at ... Conference, Orlando, FL Wednesday, March 4, ... Webcasts To access the live webcasts for these events, please ...
(Date:2/10/2015)... Inc. (NYSE: ALR), a global leader in rapid ... ended December 31, 2014. Namal Nawana, ... "We made substantial progress in the fourth quarter ... rapid diagnostics and delivering against our financial plans.  ... January enabled us to substantially reduce our debt, ...
Breaking Biology News(10 mins):World Iris Biometrics Industry 2World Iris Biometrics Industry 3World Iris Biometrics Industry 4World Iris Biometrics Industry 5World Iris Biometrics Industry 6World Iris Biometrics Industry 7World Iris Biometrics Industry 8World Iris Biometrics Industry 9World Iris Biometrics Industry 10World Iris Biometrics Industry 11Cepheid to Webcast Upcoming Financial Presentations 2Alere Inc. Announces Fourth Quarter 2014 Results 2Alere Inc. Announces Fourth Quarter 2014 Results 3Alere Inc. Announces Fourth Quarter 2014 Results 4Alere Inc. Announces Fourth Quarter 2014 Results 5Alere Inc. Announces Fourth Quarter 2014 Results 6Alere Inc. Announces Fourth Quarter 2014 Results 7Alere Inc. Announces Fourth Quarter 2014 Results 8Alere Inc. Announces Fourth Quarter 2014 Results 9Alere Inc. Announces Fourth Quarter 2014 Results 10Alere Inc. Announces Fourth Quarter 2014 Results 11Alere Inc. Announces Fourth Quarter 2014 Results 12Alere Inc. Announces Fourth Quarter 2014 Results 13Alere Inc. Announces Fourth Quarter 2014 Results 14Alere Inc. Announces Fourth Quarter 2014 Results 15Alere Inc. Announces Fourth Quarter 2014 Results 16Alere Inc. Announces Fourth Quarter 2014 Results 17Alere Inc. Announces Fourth Quarter 2014 Results 18Alere Inc. Announces Fourth Quarter 2014 Results 19Alere Inc. Announces Fourth Quarter 2014 Results 20Alere Inc. Announces Fourth Quarter 2014 Results 21Alere Inc. Announces Fourth Quarter 2014 Results 22Alere Inc. Announces Fourth Quarter 2014 Results 23Alere Inc. Announces Fourth Quarter 2014 Results 24Alere Inc. Announces Fourth Quarter 2014 Results 25
... The commission tasked with protecting Atlantic bluefin tuna has ... World Wildlife Fund. The International Commission for the Conservation ... scientists, recommendations, setting catch quotas well above sustainable levels ... the height of its spawning period. Other avenues, beyond ...
... for its pivotal role in the Genomics Education Partnership (GEP), ... undergraduate classrooms across the country. Genomics, the ... an exciting area for students to get a taste of ... 40 faculty members from a variety of schools, including a ...
... severe acute respiratory syndrome alarmed the world five years ... The coronavirus (SARS-CoV) that sickened more than 8,000 people ... in bats, but the actual animal source is not known. ... jumped from bats to humans, a team of investigators from ...
Cached Biology News:End of the line for Tuna Commission 2Research-based undergraduate course expands beyond Washington University 2Research-based undergraduate course expands beyond Washington University 3Research-based undergraduate course expands beyond Washington University 4Research-based undergraduate course expands beyond Washington University 5Synthetic virus supports a bat origin for SARS 2Synthetic virus supports a bat origin for SARS 3
(Date:3/4/2015)... Launched by the Assistance Publique - ... 2011, ,SARAH, - the French national collaborative randomized ... advanced hepatocellular carcinoma (HCC) has enrolled more than 400 ... a large French study of patients with advanced, inoperable ... patient enrolment, exceeding its 400-patient target, according to its ...
(Date:3/3/2015)... 3, 2015 NASA astronaut Scott Kelly , ... to spend a year living and working on the International ... 5:30 to 7 a.m. EDT Monday, March 9. ... he completes the final weeks of his training. The interviews ... NASA Television highlighting his mission training and previous spaceflights. ...
(Date:3/3/2015)... Diagnostics Inc. (TSX:V: SQD), a life sciences company that ... advanced microarray diagnostics, today announced it has appointed ... team. In his capacity as CFO he will ... development stage to a commercially successful company including ... market strategy and to secure funding to drive ...
(Date:3/3/2015)... -- Fried, Frank, Harris, Shriver & Jacobson LLP announced ... the Firm as a partner in the Intellectual Property ... office. Mr. Lewis concentrates on patent litigation ... intellectual property and general litigation. A trained chemical engineer ... and defendants in a range of technology-related sectors but ...
Breaking Biology Technology:Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 2Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 3Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 4Treatment of Primary Liver Cancer: SARAH Study Completes Enrolment, Results Expected Late 2016 5NASA Astronaut Scott Kelly Available for Interviews before One-Year Space Station Mission 2SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 2Leading Patent Attorney Jeffrey Lewis Joins Fried Frank's Intellectual Property Litigation Practice 3
... Genomic,Health, Inc. (Nasdaq: GHDX ) today announced ... Officer, will present at the JMP,Securities Healthcare Focus ... at 10:00 a.m. ET., To access the ... the Investor Relations section of Genomic Health,s,website at ...
... co-located conferences from October 23-24 in Washington DC. ... ... (PRWEB) September 30, 2008 -- The http://www.diahome.org/ [Drug Information ... 23-24 in Washington DC. , ,The http://www.diahome.org/DIAHOME/Education/FindEducationalOffering.aspx?productID=17158&eventType=Meeting ...
... spittlebugs, are the champion insect jumpers, capable of reaching heights ... body length. Research published today in the open access journal ... by flexing bow-like structures between their hind legs and wings ... catapult-like action. , Froghoppers are well distributed around the world. ...
Cached Biology Technology:DIA Co-located Conference to Examine Outsourcing and Project Management Best Practices 2Like an arrow: Jumping insects use archery techniques 2
... (NMPs) make up the internal structural framework of ... as DNA replication, RNA synthesis, and hormone receptor ... to be highly insoluble in vitro , ... soluble nuclear matrix proteins that can be detected ...
Request Info...
Request Info...
... is the easiest to program twin-strip ... with liquid level sensors for wash, ... orbital shaker and automatic rinsing and ... The big bottle model is designed ...
Biology Products: