Navigation Links
Injectable gel could spell relief for arthritis sufferers
Date:4/13/2011

y, they discovered a GRAS material that could be coaxed into self-assembling into a drug-containing gel. "The beauty of self-assembly is that whatever exists in solution during the assembly process--in this case, a drug--becomes entrapped," says Vemula, first author of the paper, who also has an appointment at HST.

They further expected that the same material would disassemble, releasing its drug payload, when exposed to the enzymes present during inflammations like those associated with arthritis.

Promising Results

A series of experiments confirmed this. For example, the team created a gel containing a dye as a stand-in for a drug, then exposed it to enzymes associated with arthritis. The drug was released. Further, the addition of agents that inhibited the enzymes stopped the release, indicating that the gel "can release encapsulated agents in an on-demand manner," the researchers write. Although the team has yet to test this in humans, they did find that dye was also released in response to synovial fluid taken from arthritic human joints.

Among other promising results, the researchers found that gel injected into the healthy joints of mice remained stable for at least two months. Further, the gel withstood wear and tear representative of conditions in a moving joint.

Additional tests in mice are underway. The technique has yet to be demonstrated in humans, but the researchers write that it "should have broad implications for the localized treatment of manydiseases" caused by the enzymatic destruction of tissues.

The researchers have applied for a patent on the work, which was sponsored by the Center for Integration of Medicine and Innovative Technology (CIMIT) through the U.S. Army and by the Harvard Catalyst Program.


'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. UTMB study identifies women at risk of gaining excessive weight with injectable birth control
2. Vitiligo skin disorder could yield clues in fight against melanoma
3. Saliva proteins could help detection of oral cancer
4. Research about plant viruses could lead to new ways to improve crop yields
5. Nanodiamond drug device could transform cancer treatment
6. UNC study on properties of carbon nanotubes, water could have wide-ranging implications
7. So-called sandfish could help materials handling and process technology specialists
8. Discovery of natural compounds that could slow blood vessel growth
9. Researchers design artificial cells that could power medical implants
10. Herbicide-resistant grape could revitalize Midwest wine industry
11. Sensitive laser instrument could aid search for life on Mars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/14/2015)... April 14, 2015 NXT-ID, Inc. (NASDAQ: ... company focused on the growing mobile commerce market, announces ... the 2015 New York Design Awards under the category  ... York City Design Awards are part of a global ... 2,500 ratings from the marketplace, industry and judging panel. ...
(Date:4/8/2015)... 2015  Infinisource, a leading provider of SaaS-based Human ... a leading supplier of biometric identification and security ... most advanced biometrically-enabled time clock, the companies announced ... is setting a bold, new standard for the ... small and mid-size employer. When connected to the ...
(Date:4/2/2015)... GOTHENBURG, Sweden , April 2, 2015 ... for its touch fingerprint sensor FPC1025 from the distributor ... Deliveries will commence during Q2 2015 although the major ... 2015. The sensors will be used by smartphone manufacturers ... of 110 MSEK is included in the communicated revenue ...
Breaking Biology News(10 mins):NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 2iSolved Time Clock Offers Unmatched Accuracy due to Morpho Biometrics 3Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2
... the journal Botany is set to showcase ... bringing to the study of pollination biology. The journal,s ... topics that range from the effect of flower structure ... change on pollinator ranges. The issue also includes two ...
... guts of worms are seemingly innocuous bacteria that contribute to ... same bacteria transform from harmless microbes into deadly insecticides. ... University researchers led a study that revealed how a bacteria ... member in the gut microbiome to deadly killer in insect ...
... sensation that your waistband is getting tight. Investigators reporting online ... have now mapped out the signals that travel between ... satiety after eating a protein-rich meal. Understanding this back and ... way for future approaches in the treatment and/or prevention of ...
Cached Biology News:Special issue of Botany showcases CANPOLIN research 2Jekyll and Hyde bacteria aids or kills, depending on chance 2
(Date:5/4/2015)... MEMPHIS, Tenn. , May 4, 2015 /PRNewswire-USNewswire/ ... have developed a significantly better computer tool for ... in many cancers but were difficult to identify ... the scientific journal Nature Methods . ... short for Copy Number Segmentation by Regression Tree ...
(Date:5/4/2015)... 2015 /PRNewswire/ - Fluorinov Pharma (Fluorinov), a FACIT ... of Dr. Roger J Garceau, to its Board ... in matters including corporate development and clinical strategy, ... significant regulatory expertise as Fluorinov transitions to clinical ... years of pharmaceutical development experience to Fluorinov and ...
(Date:5/4/2015)... Achieved primarily through a proprietary paraffin and ... to 100x better detail than the industry standard. ... light microscopy methods, it needed another medium to measure ... frame of reference because it represents the highest standard ... the earliest discovery days of Ultralight Histology was to ...
(Date:5/4/2015)... WASHINGTON , May 4, 2015   ... announced updated interim data from Tocagen,s ongoing investigational ... Satellite Symposium of the American Association of Neurological ... Tumors, held May 1-2, 2015, in ... the company held a meeting with FDA and ...
Breaking Biology Technology:Scientists dramatically improve method for finding common genetic alterations in tumors 2Scientists dramatically improve method for finding common genetic alterations in tumors 3Scientists dramatically improve method for finding common genetic alterations in tumors 4Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 2Roger J Garceau joins Fluorinov board, adds clinical expertise to bromodomain program and oncology pipeline 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 2Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 3Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 4Tocagen Presents Updated Interim Survival Data from Ongoing Clinical Studies at American Association of Neurological Surgeons (AANS)/Congress of Neurological Surgeons (CNS) Section on Tumors 5
... Small Tree Communications , a provider of enterprise ... for continued development of communications technology. , ,This funding, ... awarded through a competitive award process. It will enable ... the United States Army . , ,The request ...
... Wis . - Einstein Wireless , a Wisconsin-based ... alert subscribers via cell phone about natural disasters, terrorist ... first of its kind in the United States, will ... emergency alerts across most of Wisconsin, and notification equipment ...
... improperly apply its five percent sales tax to a software ... Wisconsin Supreme Court will decide that question after agreeing ... estimated $350 million at stake for businesses throughout Wisconsin, including ... of modified software, which unlike off-the-shelf software is not subject ...
Cached Biology Technology:
... a molecular screening, low melting point agarose ... It is recommended for separation of nucleic ... as PCR products. Micro ABgarose is also ... recommended for blotting techniques. At a 3% ...
Rabbit polyclonal to L Kynurenine ( Abpromise for all tested applications). Antigen: Synthetic peptide L Kynurenine conjugated to a protein carrier. Entrez Gene ID: 8942 Swiss Protein ID...
Sheep polyclonal to Salmonella Shoreditch ( Abpromise for all tested applications). Antigen: Native Salmonella shoreditch (Group D2)....
Sheep polyclonal to Salmonella Thomasville ( Abpromise for all tested applications). Antigen: Native Salmonella thomasville...
Biology Products: