Inhibiting proteins may prevent cartilage breakdown in arthriti... (earchers identified an active site in th...)

Inhibiting proteins may prevent cartilage breakdown in arthritis patients

Date:2/18/2009

earchers identified an active site in the SAF-1 protein molecule that is involved in the interaction with AP-1 to induce the expression of the MMP-1 gene.

"In this study, we looked at how and why MMP-1 is activated, particularly in the disease condition," Ray said. "Once we understand how this gene is activated, we can design drugs to control pathways to reduce the severity of MMP-1-mediated cartilage destruction. We found strong evidence that by blocking SAF-1, MMP-1 expression is inhibited. Now, we will continue to explore the interacting domain of SAF-1 as a possible contact point for competitive inhibition."

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Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

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Inhibiting proteins may prevent cartilage breakdown in arthriti...(earchers identified an active site in th...)