Navigation Links
Inhibiting proteins may prevent cartilage breakdown in arthritis patients
Date:2/18/2009

COLUMBIA, Mo. Current arthritis medications can ease the pain, but stopping the progression of the disease requires more aggressive treatments: use of very limited available drugs or surgical intervention. University of Missouri researchers hope to find new therapeutic targets for arthritis by studying the interaction between two proteins that, if interrupted, may prevent arthritis pain caused by joint damage. In a new study, researchers have found potential evidence that blocking the proteins responsible for inducing inflammation prevents cartilage breakdown.

"We are looking to intervene in specific molecular events to prevent the depletion of cartilage in arthritis," said Bimal K. Ray, professor of veterinary pathobiology in the MU College of Veterinary Medicine. "Certain proteins play a major role in the development of arthritis. When we understand how these proteins interact, we will have a better idea of how to slow or even reverse the progression of the disease."

When the human body develops arthritis, specific protein functions are altered and inflammation is triggered, leading to pain. In the MU study, Ray examined the interaction between the proteins AP-1 and SAF-1 and found that the interaction of these proteins plays a significant role in inducing inflammation. SAF-1 and AP-1 can partner to work together to induce activation of the MMP-1 gene causing breakdown of collagen (the proteins that constitute cartilage). Arthritis patients start to experience pain when cartilage starts to erode.

Because AP-1 and SAF-1 play a significant role in the activation of the MMP-1 gene, researchers explored the site of the interaction as a possible contact point for competitive inhibition. In competitive inhibition, a molecule binds with an enzyme or a protein to decrease its activity and disable its function. Many pharmaceutical drugs that are successful for treating other diseases rely on enzyme inhibitors. In this study, researchers identified an active site in the SAF-1 protein molecule that is involved in the interaction with AP-1 to induce the expression of the MMP-1 gene.

"In this study, we looked at how and why MMP-1 is activated, particularly in the disease condition," Ray said. "Once we understand how this gene is activated, we can design drugs to control pathways to reduce the severity of MMP-1-mediated cartilage destruction. We found strong evidence that by blocking SAF-1, MMP-1 expression is inhibited. Now, we will continue to explore the interacting domain of SAF-1 as a possible contact point for competitive inhibition."


'/>"/>

Contact: Kelsey Jackson
JacksonKN@missouri.edu
573-882-8353
University of Missouri-Columbia
Source:Eurekalert

Related biology news :

1. Tumor-inhibiting protein could be effective in treating leukemia
2. Researchers find cancer-inhibiting compound under the sea
3. LSUHSC awarded patent for compound inhibiting cancer and other diseases
4. The bonsai effect: Wounded plants make jasmonates, inhibiting cell division, stunting growth
5. Researchers identify proteins involved in new neurodegenerative syndrome
6. NIH awards researcher $1.5 million new innovator grant for fruit-fly studies of prion proteins
7. Depression, aging, and proteins made by a virus may all play role in heart disease
8. New approach builds better proteins inside a computer
9. Legionnaires bacterial proteins work together to survive
10. Proteins pack tighter in crowded native state
11. MIT IDs proteins key to brain function
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/19/2017)... , April 19, 2017 The ... vendor landscape is marked by the presence of several ... however held by five major players - 3M Cogent, ... companies accounted for nearly 61% of the global military ... companies in the global military biometrics market boast global ...
(Date:4/17/2017)... 17, 2017 NXT-ID, Inc. (NASDAQ: NXTD ... filing of its 2016 Annual Report on Form 10-K on Thursday ... ... available in the Investor Relations section of the Company,s website at ... website at http://www.sec.gov . 2016 Year Highlights: ...
(Date:4/13/2017)... , April 13, 2017 According to a ... Identity Authentication, Identity Analytics, Identity Administration, and Authorization), Service, Authentication Type, Deployment ... the IAM Market is expected to grow from USD 14.30 Billion in ... Rate (CAGR) of 17.3%. ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:5/23/2017)... ... May 23, 2017 , ... Kathy Goin is joining ... Operations. She brings years of expertise in establishing and leading clinical operations at ... a licensed occupational therapist, through a variety of leadership roles in Clinical Operations, ...
(Date:5/23/2017)... Massachusetts (PRWEB) , ... May 23, 2017 , ... ... making a splash at this year’s Bio-IT World Conference and Expo in ... Smart Data Lake® 4.0 solution. The Anzo Smart Data Lake is also a ...
(Date:5/22/2017)... ... May 22, 2017 , ... Stratevi, a boutique firm that partners with healthcare ... has opened an office in downtown Boston at 745 Atlantic Ave. , “We ... to generate evidence on the value they provide, not just to patients, but also ...
(Date:5/22/2017)... ... May 22, 2017 , ... Cancer diagnostics and pathology workflow ... at the Association for Pathology Informatics Annual Summit at the Wyndham ... its Cancer Diagnostic Cockpit and Consultation Portal, Inspirata will present research it led ...
Breaking Biology Technology: