Navigation Links
Inhibiting cell signaling pathway may improve bone marrow transplant success rate
Date:9/26/2010

CINCINNATI Identification of a molecular communications pathway that influences the mobilization of hematopoietic (blood) stem cells could lead to targeted therapies for improving bone marrow transplant success rates.

In a bed-side to bench approach, researchers at Cincinnati Children's Hospital Medical Center report Sept. 26 in Nature Medicine that pharmacological inhibition of a signaling pathway triggered by Egfr (epidermal growth factor receptor) increased the mobilization of hematopoietic stem cells in mice. The finding provides a scientific basis for enhancing the effectiveness of autologous bone marrow transplants, in which the recipient donates his or her own stem cells prior to the procedure.

"Up to 10 percent of bone marrow donors fail to mobilize sufficient numbers of stem cells, which impedes autologous transplants and significantly delays transplant recovery time," said Hartmut Geiger, Ph.D., a researcher in the division of Experimental Hematology/Cancer Biology at Cincinnati Children's and senior investigator on the study. "Our findings reveal a new rationale for targeted pharmacological approaches to improve stem cell mobilization and transplantation outcomes."

Autologous bone marrow transplant is often used to restore a person's hematologic system after receiving radiation therapy for cancer treatment. Radiation exposure damages the system, which produces all of the body's blood cell types including those vital to immune system function.

In clinical hematopoietic stem cell (HSC) transplants, the preferred source for mobilizing hematopoietic stem cells from bone marrow into peripheral circulating blood is by targeting a signaling protein called granulocyte colony stimulating factor, or G-CSF. G-CSF stimulates bone marrow so that it releases HSCs into circulating peripheral blood. Mobilization failures and delayed recovery rates suggest the need for a deeper molecular understanding of the mobilization
'/>"/>

Contact: Nick Miller
nicholas.miller@cchmc.org
513-803-6035
Cincinnati Children's Hospital Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Inhibiting serotonin in gut could cure osteoporosis
2. New strategy for inhibiting virus replication
3. Corrosion-inhibiting coatings containing good bacteria
4. Inhibiting proteins may prevent cartilage breakdown in arthritis patients
5. The bonsai effect: Wounded plants make jasmonates, inhibiting cell division, stunting growth
6. LSUHSC awarded patent for compound inhibiting cancer and other diseases
7. Investigators discover a new hot spot for the genesis of signaling neurons in the adult brain
8. New molecular signaling cascade increases glucose uptake
9. Scientists post lower speed limit for cell-signaling protein assembly
10. Insulin signaling key to caste development in bees
11. Cell signaling classification system gives researchers new tool
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/18/2014)... pills in Peru found that 28 percent of ... or falsified. Many pills released the active ingredient ... One batch had no active ingredient at all. ... at the Georgia Institute of Technology developed a ... suspected counterfeit drugs and then characterize their chemical ...
(Date:4/18/2014)... Seeds that sprout as soon as they,re planted may ... to be more careful. In the wild, a plant whose ... would risk disaster. More than just an insurance policy against ... seed dormancy has long-term advantages too: Plants whose seeds ... to more species, finds in a team of researchers working ...
(Date:4/17/2014)... Double-stapled peptide inhibits RSV infection , Respiratory ... lower respiratory tract infections, generating life-threating illness in ... preventive therapies are limited. RSV enters host cells ... a six-helix fusogenic bundle. Small interfering peptides that ... however, these peptides are highly susceptible to degradation. ...
Breaking Biology News(10 mins):Counterfeit contraceptives found in South America 2Counterfeit contraceptives found in South America 3Plants with dormant seeds give rise to more species 2JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6
... and Interventional Radiology"an essential resource and the first offering ... armis now available. Also available is the companion "Patient ... Written by top experts in their areas of specialty, ... or in training, for certification or recertification or for ...
... In a lecture he delivered in 1906, the German ... as shorthand for a highly targeted medical treatment. Magic ... that only silver bullets can kill supernatural creatures, remain the ... scientists at Washington University in St. Louis is currently working ...
... New findings that shed light on how genetic damage ... of the rare muscle-wasting disease, nemaline myopathy, are reported ... Professor Laura Machesky and colleagues from the CRUK Beatson ... muscle cells that displayed mutations of the ACTA1 gene ...
Cached Biology News:Society of Interventional Radiology Press offers new edition of patient care resource 2A golden bullet for cancer 2A golden bullet for cancer 3A golden bullet for cancer 4A golden bullet for cancer 5New clues about the basis of muscle wasting disease 2
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: ... and commercializing innovative therapies addressing major unmet medical ... received the Notice of Allowance from the United ... self-delivering RNAi compounds (sd-rxRNA®), for the treatment of ...
(Date:1/14/2014)... 2014   Kinaxis ®, provider of RapidResponse ®, a ... operations planning ( S&OP ) service, is proud to be ... will be held at the Hilton San Diego Bayfront, January ... Elisabeth Kaszas , Director of Supply Chain at Amgen, ...
(Date:1/14/2014)... Kerr Corporation, a leading manufacturer of innovative dental products, has ... arch impressions on its dental blog. , Titled ... serves up a list of tips to help dentists best ... David Little as he crafts a porcelain crown using Kerr’s ...
(Date:1/14/2014)... Independent publisher Bitingduck Press, with offices in Altadena ... ideas for 2014 in production and sales of interactive ... high-quality, low-cost, DRM-free ebooks and to use the sales ... first major development will be bookstore sales in local ...
Breaking Biology Technology:RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2Bitingduck Press Looks Forward to 2014 With Multimedia E-books 2
... 2011 Practice Fusion ... part of Health 2.0,s Spring Developer Challenge. Using Practice ... through Microsoft,s Windows Azure Marketplace, Epicenter developer and self-confessed ... identify and better control the spread of disease across ...
... 22, 2011 VENENUM Biodesign, a drug discovery company ... collection to identify hits against its novel disease-based targets ... be exhibiting at the 17th SBS Annual Conference & ... in Orlando, Florida, March 27-31, 2011. VENENUM Biodesign will ...
... growth" technique for fabricating nanoribbons of epitaxial graphene has ... conduct current with almost no resistance. These structures ... with conventional architectures and set the stage for ... the quantum properties of electrons. "We can now ...
Cached Biology Technology:Disease Control App for Doctors Wins Health 2.0 Data Challenge, Analyze This! 2Disease Control App for Doctors Wins Health 2.0 Data Challenge, Analyze This! 3Disease Control App for Doctors Wins Health 2.0 Data Challenge, Analyze This! 4VENENUM Biodesign to Exhibit at SBS 2Templated growth technique produces graphene nanoribbons with metallic properties 2Templated growth technique produces graphene nanoribbons with metallic properties 3Templated growth technique produces graphene nanoribbons with metallic properties 4
Troponin I (22B11)...
Microlite 1+ 1x12 Strip assembled, flat bottom; the ideal vessel for low signal luminescent reactions, offering medium binding with enhanced dynamic range, extra high reflectivity and minimal cross t...
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake....
... and pressurized syringe holder for any researcher who ... rate Microinjecting Fine microliter delivery ... to any new or existing perfusion rig - ... Connect to house air or a compressor (30 ...
Biology Products: