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Inherited gene variation tied to high-risk pediatric leukemia and greater risk of relapse
Date:10/20/2013

gene, compared to 29 percent of patients with other ALL subtypes and 20 percent of those without ALL. When researchers checked for the high-risk variant in additional patients with the Ph-like ALL subtype as well as other young ALL patients and individuals without the disease, they found the similar percentages carried the high-risk version.

Researchers found evidence the high-risk version of the gene was associated with significantly increased production of the GATA3 protein in cells growing in the laboratory. Investigators also found evidence that excess GATA3 activity in leukemia cells led to changes in the activity of other genes that mirrored Ph-like ALL. "Because this variant causes higher expression of GATA3 from birth, we suspect that this increased level of GATA3 may set the stage for developing Ph-like ALL later," said first author Virginia Perez-Andreu, M.D., Ph.D., a St. Jude postdoctoral fellow in the pharmaceutical sciences department.


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Contact: Summer Freeman
media@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert  

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Inherited gene variation tied to high-risk pediatric leukemia and greater risk of relapse
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