Navigation Links
Inherited gene variation tied to high-risk pediatric leukemia and greater risk of relapse
Date:10/20/2013

le was known about why a child develops a specific subtype of ALL in the first place and whether inherited genetic variations that predispose an individual to a subtype also influence how he or she responds to the therapy," said corresponding author Jun J. Yang, Ph.D., an assistant member of the St. Jude Department of Pharmaceutical Sciences. "In this study, we discovered a genetic basis for susceptibility to Ph-like ALL, but even more importantly, the evidence that host and tumor genomes may interact with each other to influence the risk of developing and surviving ALL."

The study was done in collaboration with the Children's Oncology Group, a U.S.-based research cooperative study group focused on childhood cancer research and clinical trials. The research included 680 patients enrolled in COG clinical trials.

Ph-like ALL accounts for as much as 15 percent of childhood ALL and is associated with a high risk of relapse and a poor outcome. ALL is the most common childhood cancer. While overall cure rates for pediatric ALL are now about 90 percent, only 63 percent of children with Ph-like ALL are alive and cancer free after five years. Yang added that larger population studies are needed to assess risks associated with these inherited variations.

GATA3 carries instructions for assembling a protein called a transcription factor that turns other genes on and off. The GATA3 protein, and other members of the GATA gene family, plays a crucial role in normal development of a variety of blood cells. Alterations in GATA3 have been linked to other blood cancers, including Hodgkin lymphoma.

The high-risk GATA3 variation was identified using a library of 718,890 common genetic variations known as single nucleotide polymorphisms, or SNPs, to screen the DNA of 75 children with Ph-like ALL, 436 children with other ALL subtypes and 6,661 individuals without ALL. Fifty-eight percent of patients with Ph-like ALL carried the high-risk version of the
'/>"/>

Contact: Summer Freeman
media@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. New research on inherited herpesvirus may have implications for transplantation
2. Gene mutations caused by a fathers lifestyle can be inherited by multiple generations
3. Non-inherited mutations account for many heart defects, Yale researchers find
4. Cell discovery could hold key to causes of inherited diseases
5. Born to lead? Leadership can be an inherited trait, study finds
6. Researchers discover 2 genetic flaws behind common form of inherited muscular dystrophy
7. The Johns Hopkins Center for Inherited Disease Research receives $101 million
8. UMMS researchers isolate gene mutations in patients with inherited amyotrophic lateral sclerosis
9. New compound holds promise for treating Duchenne MD, other inherited diseases
10. UF receives $1 million from Keck Foundation to study mechanisms of inherited disease
11. Functional genetic variation in humans: Comprehensive map published
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inherited gene variation tied to high-risk pediatric leukemia and greater risk of relapse
(Date:8/26/2014)... a protective tent over a colony of harmful ... especially difficult. Microorganisms protected in a biofilm pose ... resistance and recalcitrance to treatment, and biofilm-protected bacteria ... infections in humans and are 50 to 1,000 ... infections. , "In essence, we may have stumbled ...
(Date:8/26/2014)... Illinois engineers are bringing a touch of color ... new continuous glucose monitoring material that changes color ... is so precise that doctors and patients may ... dosing - something not possible using current ... significant limitations to current continuous glucose monitoring technologies," ...
(Date:8/26/2014)... and optical microresonators, researchers at the University of ... amplifier (or laser) design, paving the way for ... systems at the microscopic scale that amplify light ... Eden, a professor of electrical and computer engineering ... well-suited for routing optical power on a chip ...
Breaking Biology News(10 mins):Breakthrough antibacterial approach could resolve serious skin infections 2Breakthrough antibacterial approach could resolve serious skin infections 3A glucose meter of a different color provides continuous monitoring 2A glucose meter of a different color provides continuous monitoring 3Symphony of nanoplasmonic and optical resonators produces laser-like light emission 2
... more than 180 research papers suggests fish oils could minimise ... a review by researchers at the University of Liverpool has ... and Chronic Disease reviewed research from around the world to ... omega-3s had a role to play in aiding weight loss. ...
... complex, weight-bearing hips of walking animals from the basic hips ... Tetrapods, or four-legged animals, first stepped onto land about ... by strong hipbones and a connection through the spine via ... fish ancestors of tetrapods. In a study published ...
... Biotechnology (DBT) and Bharat Biotech announced positive results from ... developed and manufactured in India. Data from the trial, ... for IndiaThe Evidence and the Promise, showed ROTAVAC to ... The clinical study demonstrates for the first time that ...
Cached Biology News:Fish oil may stall effects of junk food on brain 2From ocean to land: The fishy origins of our hips 2Rotavirus vaccine developed in India demonstrates strong efficacy 2Rotavirus vaccine developed in India demonstrates strong efficacy 3Rotavirus vaccine developed in India demonstrates strong efficacy 4
(Date:8/26/2014)... -- An analysis by Replikins, Ltd. of Pubmed data ... virus strains has revealed extensive conservation and sharing ... and sharing of specific Replikin gene structures has permitted ... it did for the H5N1 influenza vaccine and the ... found to be effective (1,2). This ...
(Date:8/26/2014)... Israel , August 26, 2014 ... 3DM, supports NHS hospitals with surgery validation using its Stratasys ... - Performing surgery on 3D printed models prior to ... and provides an effective aid for both patient and surgeon ... SSYS ), a global leader of 3D printing and ...
(Date:8/26/2014)... AVENTURA. Fla. , Aug. 26, 2014 /PRNewswire/ ... trades under the symbol (NUUU) has two (2) ... Inc. Our two subsidiaries harness scientifically advanced technology ... NUUU,s Renuell Int,l, Inc. ... breakthrough anti-aging skin care products that is made ...
(Date:8/26/2014)... 2014 Trovagene, Inc. (NASDAQ:  TROV) presented ... Moving Assays to the Clinic with an ... Cell Free Tumor DNA in Urine." In this ... Precision Cancer Monitoring (PCM) platform and results from ... detection of tumor DNA mutations from urine samples ...
Breaking Biology Technology:Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 2Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 3Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 4Twelve UK Hospitals Enjoy Reduced Surgical Procedure Times and Decline in Costs by Implementing Stratasys 3D Printing Solutions 5Technology Applications International Corporation, Trading Symbol NUUU now trading on NASDAQ's Over the Counter Bulletin Board (OTC BB) 2Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 2Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 3Highly Sensitive and Quantitative Analytical Performance is Translational for Clinical Utility of Cell-Free Tumor DNA Diagnostics 4
... is becoming more and more a rare option rather than ... still getting feedback about people giving two-weeks' notice and then ... notices no longer are part of the standard practice. , ... , ,One reader said you should give a two-week notice ...
... leaves behind an economic year in which some new investments ... tech economy positioned itself to prosper in some emerging sectors. ... investment climate must remain warm and state policymakers need to ... ability to compete in the global marketplace. What's in store ...
... Dow Jones Industrials had a fabulous year and outperformed ... very solid year, by a large margin. The two key ... because the different composition of each. , ,The NASDAQ Biotech ... greater spectrum of the biotech industry (larger and smaller companies), ...
Cached Biology Technology:Two-week notices: People are still concerned 2Two-week notices: People are still concerned 3Two-week notices: People are still concerned 4Two-week notices: People are still concerned 5Wisconsin's high-growth economy: '07 predictions 2Wisconsin's high-growth economy: '07 predictions 3Wisconsin's high-growth economy: '07 predictions 42006: A mixed blessing for Midwest life science companies 22006: A mixed blessing for Midwest life science companies 32006: A mixed blessing for Midwest life science companies 42006: A mixed blessing for Midwest life science companies 52006: A mixed blessing for Midwest life science companies 62006: A mixed blessing for Midwest life science companies 72006: A mixed blessing for Midwest life science companies 82006: A mixed blessing for Midwest life science companies 92006: A mixed blessing for Midwest life science companies 102006: A mixed blessing for Midwest life science companies 11
... Have you bought a Perkin Elmer UltraVIEW system ... the Andor iXon and iQ software? No problem. ... upgrade. You keep your existing microscope, lasers, Sutter ... customise it to work with our precision controller ...
...
... is a 96-well ELISA-compatible plate (containing 12 x ... Monoclonal Antibody is immobilized by a method that ... the tail fiber protein of the T7 bacteriophage. ... 10 9 phage per well and low ...
... The TRAPeze RT Telomerase Detection ... in vitro assay for the ... quantification of telomerase activity. It ... TRAPeze assay and adds the ...
Biology Products: