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Inheritance of lifespan is sex-dependent in fruit flies
Date:9/13/2013

th from the Faculty of Biology one of the authors of the study.

The authors then used the data from the hemi-cloned fruit flies to read off how similar the individuals in a hemi-clone are and how far females and males from one hemi-clone share the same lifespan. Results showed that the lifespan was very similar within sexes, whereas the calculated relation between sexes was only slight. Hence, Methuselah genes in the father exert only a limited influence on female descendants at least in fruit flies. Vice versa, particularly long-lived females do not necessarily have long-lived brothers, fathers, or sons. Approximately three-quarters of the genetic components of life expectation are effective only within the same sex.

The researchers conclude that the risk of a fatal hereditary disease is passed on above all within the same sex. 'Gene variants that could be problematic for one sex seem to have only a comparatively low influence on the life expectation of the other sex', says Holger Schielzeth. In principle, this finding could also generalize to human beings, because human life expectancy is also hereditary. According to Schielzeth, this sex-specific heredity may also be relevant for medicine, and that therapies should pay more attention to sex-specific risks.


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Contact: Dr. Holger Schielzeth
holger.schielzeth@uni-bielefeld.de
49-521-106-2820
University of Bielefeld
Source:Eurekalert

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