Navigation Links
Inheritance of lifespan is sex-dependent in fruit flies

This news release is available in German.

Like mother, like daughter; like father, like son. Evolutionary biologists at the universities in Bielefeld (Germany) and Uppsala (Sweden) have now shown that this proverb also applies to inheriting a long life at least for fruit flies (Drosophila). The research team found that the descendants of these insects mostly inherit their lifespan from their own sex: male descendants will very probably live about as long as their fathers; female descendants, about as long as their mothers. The scientists have published their findings on Thursday 12 September in the renowned journal American Naturalist".

The new study by the GermanSwedish research team has turned a previous assumption by biologists and physicians upside down: up to now, they had thought that the genetic risk of a disease was equally strong in both female and male descendants.

The study proceeded from the assumption that the average life expectancy of women and men differs this may be for genetic reasons but also due to different lifestyles. The GermanSwedish research team wanted to find out how far this sex difference in the lifespan depends on the genetic make-up.

To carry out their experiments, the researchers intervened in the heredity of fruit flies by cross-breeding them with special fly mutants. This enabled them to breed 50 hemi-clones; that is, groups of individuals in whom one-half of the genetic make-up is absolutely identical, whereas the other half is completely unrelated. From each hemi-clone, the researchers determined the lifespan of 400 females and 400 males. 'What's special about this approach is that it enables us to measure the influence of this 50 per cent identical genetic make-up in both sexes', says Dr. Holger Schielzeth from the Faculty of Biology one of the authors of the study.

The authors then used the data from the hemi-cloned fruit flies to read off how similar the individuals in a hemi-clone are and how far females and males from one hemi-clone share the same lifespan. Results showed that the lifespan was very similar within sexes, whereas the calculated relation between sexes was only slight. Hence, Methuselah genes in the father exert only a limited influence on female descendants at least in fruit flies. Vice versa, particularly long-lived females do not necessarily have long-lived brothers, fathers, or sons. Approximately three-quarters of the genetic components of life expectation are effective only within the same sex.

The researchers conclude that the risk of a fatal hereditary disease is passed on above all within the same sex. 'Gene variants that could be problematic for one sex seem to have only a comparatively low influence on the life expectation of the other sex', says Holger Schielzeth. In principle, this finding could also generalize to human beings, because human life expectancy is also hereditary. According to Schielzeth, this sex-specific heredity may also be relevant for medicine, and that therapies should pay more attention to sex-specific risks.


Contact: Dr. Holger Schielzeth
University of Bielefeld

Related biology news :

1. Defying the laws of Mendelian inheritance
2. Herbal extract boosts fruit fly lifespan by nearly 25 percent, UCI study finds
3. Lifespan-extending drug given late in life reverses age-related heart disease in mice
4. Ease of access improves fruit and vegetable consumption
5. Red delicious or wolf apple? Brazilian savanna fruits high in antioxidants
6. Latino families in study eat more fruits and veggies, drink less soda
7. The worlds favorite fruit only better-tasting and longer-lasting
8. Is the humble fig more than just a fruit?
9. Diverse bacteria on fresh fruits, vegetables vary with produce type, farming practices
10. Study offers new insights on invasive fly threatening US fruit crops
11. Wild pollinators increase crop fruit set regardless of honey bees
Post Your Comments:
(Date:6/16/2016)... 16, 2016 The global ... to reach USD 1.83 billion by 2024, according ... Inc. Technological proliferation and increasing demand in commercial ... to drive the market growth.      ... The development of advanced multimodal techniques for biometric ...
(Date:6/9/2016)...  Perkotek an innovation leader in attendance control systems is proud to announce the ... employers to make sure the right employees are actually signing in, and to even ... ... ... ...
(Date:6/7/2016)... , June 7, 2016  Syngrafii Inc. ... a business relationship that includes integrating Syngrafii,s patented ... branch project. This collaboration will result in greater ... the credit union, while maintaining existing document workflow ... ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... -- Liquid Biotech USA , Inc. ... Research Agreement with The University of Pennsylvania ("PENN") ... patients.  The funding will be used to assess ... outcomes in cancer patients undergoing a variety of ... to support the design of a therapeutic, decision-making ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Researchers at ... most commonly-identified miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the ... read it now. , Diagnostic biomarkers are signposts in the blood, lung fluid ...
(Date:6/23/2016)... SILVER SPRING, Md. , June 23, 2016 ... evidence collected from the crime scene to track the criminal ... sick, and the U.S. Food and Drug Administration (FDA) uses ... Sound far-fetched? It,s not. ... whole genome sequencing to support investigations of foodborne illnesses. Put ...
(Date:6/23/2016)... , June 23, 2016   EpiBiome , ... secured $1 million in debt financing from Silicon Valley ... up automation and to advance its drug development efforts, ... new facility. "SVB has been an incredible ... the services a traditional bank would provide," said Dr. ...
Breaking Biology Technology: