Navigation Links
Inhaling nitric oxide eases pain crises in sickle cell patients
Date:10/19/2010

AUGUSTA, Ga. Inhaling nitric oxide appears to safely and effectively reduce pain crises in adults with sickle cell disease, researchers report.

A study of 18 patients in Atlanta, Chicago and Detroit showed that the nine inhaling nitric oxide for four hours had better pain control than those receiving only the standard self-administered morphine, said Dr. C. Alvin Head, chairman of the Department of Anesthesiology at the Medical College of Georgia School of Medicine.

"This study shows that you can breathe the gas and have less pain, which is the major reason sickle cell patients are admitted to the hospital," said Head, corresponding author of the study published in the American Journal of Hematology.

A larger study will help define the optimal dose as well as timing and duration for the treatment, Head said. If findings continue to hold, he envisions sickle cell patients, much like asthmatics, having nitric oxide inhalers handy to forestall a full-blown pain crisis. The pain results when sickle cell patients' abnormally shaped hemoglobin impedes oxygen delivery.

"By the time you see a patient in the emergency room or the clinic, they have a significant amount of pain and you are always playing catch-up," Head said. "The idea would be to use this as early as possible."

While it's not certain how nitric oxide helps, Head has laboratory evidence and some early clinical indications that nitric oxide, which has a great affinity for hemoglobin, restore's hemoglobin's natural shape and charge. The more normal negative charge helps cells repel each other, melts sticky polymers and may prevent new ones from forming. In fact, he suspects that one of nitric oxide's usual duties in the body is to help prevent clot formation.

"If you have pain relief without more narcotic then we must be attacking the problem," Head noted. The study participants receiving nitric oxide use slightly less morphine than the control group and continued to exper
'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Inhaling a heart attack: How air pollution can cause heart disease
2. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
3. Septic shock: Nitric oxide beneficial after all
4. Treating neonatal meningitis -- is nitric oxide a foe or a friend to bacteria?
5. Carbon dioxide scrubber captures greenhouse gases
6. Nitrous oxide emissions respond differently to no-till depending on the soil type
7. Revised theory suggests carbon dioxide levels already in danger zone
8. Engineer to present leak-proof method for carbon dioxide storage at international conference
9. MIT: Safe storage of greenhouse-gas carbon dioxide
10. Carbon dioxide already in danger zone, warns study
11. ESA tests laser to measure atmospheric carbon dioxide
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inhaling nitric oxide eases pain crises in sickle cell patients
(Date:1/22/2015)... MELBOURNE, Fla. , Jan. 13, 2015  Today, ... wearable technology, launched its crowdfunding campaign on Fundable, ... accelerate the build of production capacity to meet ... Photo - http://photos.prnewswire.com/prnh/20150113/168790 ...
(Date:1/22/2015)... man-made form of insulin delivered by nasal spray may ... with mild cognitive impairment and Alzheimer,s disease dementia, according ... Forest Baptist Medical Center. The study,s subjects ... (MCI) or mild to moderate Alzheimer,s dementia (AD). Those ...
(Date:1/22/2015)... YORK , Jan. 21, 2015  Analyst Report Issued by ... Card Brands report showed that planet-wide, transactions at merchants on ... while the total number of credit, debit, and prepaid cards ... U.S. were victims of fraudulent card usage in 2012, and ...
Breaking Biology News(10 mins):FreeWavz Launches on Fundable to Drive Speed-to-Market in 2015 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 2Nasal Spray with Insulin Equivalent Shows Promise as Treatment for Adults with Mild Cognitive Impairment, Alzheimer's Dementia 3$4.80 Near Term Price Target with "Buy" given by CapRock Research for NXT-ID, Inc. (NASDAQ: NXTD) issued by Small Cap IR 2
... for months after a traumatic brain injury (TBI), revealing ... new research led by the University of Melbourne, Australia ... Neurotrauma Initiative is published in the latest issue of ... Around 400,000 Australians have a disability related to traumatic ...
... PDL BioPharma, Inc. (PDL) (Nasdaq: PDLI ) ... results on Wednesday, November 10, 2010 after the markets close. PDL,s ... Eastern Time to discuss the financial results.   ... call via phone, please dial (866) 271-5140 from the United States ...
... HAGUE (2 November 2010)A unique acacia known as a "fertilizer ... maize yields in smallholder agriculture in Zambia and Malawi, according ... The findings were central to the arguments of agroforestry experts ... technology more widely throughout the African nations most vulnerable to ...
Cached Biology News:Study provides treatment hope for long term effects of brain trauma 2PDL BioPharma to Announce Third Quarter 2010 Financial Results on November 10, 2010 2Scientists find that evergreen agriculture boosts crop yields 2Scientists find that evergreen agriculture boosts crop yields 3
(Date:3/3/2015)... 3, 2015 /CNW/- SQI Diagnostics Inc. (TSX:V: SQD), a life ... and products for advanced microarray diagnostics, today announced ...  to its Management team. In his capacity as ... transition from a development stage to a commercially ... the Company,s capital market strategy and to secure ...
(Date:3/3/2015)... LITTLE FALLS, N.J. , March 3, 2015 /PRNewswire/ ... a biotechnology company specializing in the development of and ... of damaged tissues and organs, announced today that it ... Purchase Agreement with Amarantus Bioscience Holdings, Inc. (OTC Bulletin ... required under the Agreement, Amarantus made the final payments ...
(Date:3/3/2015)... 3, 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX) ("the ... journal, Expert Opinion on Biological Therapy , Dr. ... Zhenggang Zhang , at the Henry Ford Hospital in ... beta 4 (TB4) has the capacity to promote CNS ... more post-injury, leading to neurological recovery in each case.  ...
(Date:3/3/2015)... 3, 2015 Kindred Biosciences, Inc. (NASDAQ: ... the lives of pets, announced today that it will release ... 12, 2015 after the market close. The Company will host ... Interested parties may access the call by ... internationally, and using conference ID 98449349.  The ...
Breaking Biology Technology:SQI Diagnostics Appoints Chief Financial Officer 2SQI Diagnostics Appoints Chief Financial Officer 3Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 2Regenicin (RGIN) Receives $2.3 Million in Final Payment from Amarantus 3Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 2Researchers at Henry Ford Hospital Propose Thymosin Beta 4 as Novel Way to Treat Neural Injury and Neurodegenerative Diseases 3
... May 26 , - Production Increase Brings ... Therapeutics (Euronext: AMT), a leader in the field,of ... a Cooperative,Research and Development Agreement from the National ... Institutes of Health (NIH), Bethesda,Maryland, that promises to ...
... AMLN ) will Web cast its Annual Meeting ... PT from the company,s corporate,headquarters in San Diego, CA. ... Executive Officer of Amylin Pharmaceuticals,will be providing a corporate ... and a recording will be made,available following the event. ...
... - Oncolytics Biotech Inc. (TSX:,ONC, NASDAQ: ONCY) ... Patent 2,360,833 entitled "Reovirus for the Treatment ... use of one or more,recombinant reoviruses to ... provides the Company with additional patent protection ...
Cached Biology Technology:AMT's Cooperative Research and Development Agreement With NIH to Boost Production Capacity 2AMT's Cooperative Research and Development Agreement With NIH to Boost Production Capacity 3Oncolytics Biotech Inc. Announces Issuance of 9th Canadian Patent 2
HES-1 [Hairy 1], Available Summer 2003...
E1A (adenovirus early region 1)...
... 1 ( Abpromise for all tested ... peptide: MAATGANAEK AESHNDCPVR LLNPNIAKMK EDILYHFNLT TSRHNFPALF GDVKFVCVGG ... acids 1-99 of Human Uridine Phosphorylase 1 ... 7378 Swiss Protein ID: ...
Nucleobindin 1 [NUCB1]...
Biology Products: