Navigation Links
Inhaling nitric oxide eases pain crises in sickle cell patients
Date:10/19/2010

AUGUSTA, Ga. Inhaling nitric oxide appears to safely and effectively reduce pain crises in adults with sickle cell disease, researchers report.

A study of 18 patients in Atlanta, Chicago and Detroit showed that the nine inhaling nitric oxide for four hours had better pain control than those receiving only the standard self-administered morphine, said Dr. C. Alvin Head, chairman of the Department of Anesthesiology at the Medical College of Georgia School of Medicine.

"This study shows that you can breathe the gas and have less pain, which is the major reason sickle cell patients are admitted to the hospital," said Head, corresponding author of the study published in the American Journal of Hematology.

A larger study will help define the optimal dose as well as timing and duration for the treatment, Head said. If findings continue to hold, he envisions sickle cell patients, much like asthmatics, having nitric oxide inhalers handy to forestall a full-blown pain crisis. The pain results when sickle cell patients' abnormally shaped hemoglobin impedes oxygen delivery.

"By the time you see a patient in the emergency room or the clinic, they have a significant amount of pain and you are always playing catch-up," Head said. "The idea would be to use this as early as possible."

While it's not certain how nitric oxide helps, Head has laboratory evidence and some early clinical indications that nitric oxide, which has a great affinity for hemoglobin, restore's hemoglobin's natural shape and charge. The more normal negative charge helps cells repel each other, melts sticky polymers and may prevent new ones from forming. In fact, he suspects that one of nitric oxide's usual duties in the body is to help prevent clot formation.

"If you have pain relief without more narcotic then we must be attacking the problem," Head noted. The study participants receiving nitric oxide use slightly less morphine than the control group and continued to experience pain relief two hours after the therapy ended. No patients showed signs of nitric oxide toxicity.

Head suspects morphine will eventually be replaced by a mix of other drugs, such as nitric oxide, that address the pain's root cause.

He is planning human and animal studies to see if extremely low doses of nitric oxide during pregnancy also can improve delivery rates. "We think it will be productive so the mother has fewer crises, less stress, more blood flow to the placenta and an improved chance of a baby to be delivered," Head said.


'/>"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
Source:Eurekalert  

Related biology news :

1. Inhaling a heart attack: How air pollution can cause heart disease
2. Nitric oxide-releasing wrap for donor organs and cloth for therapeutic socks
3. Septic shock: Nitric oxide beneficial after all
4. Treating neonatal meningitis -- is nitric oxide a foe or a friend to bacteria?
5. Carbon dioxide scrubber captures greenhouse gases
6. Nitrous oxide emissions respond differently to no-till depending on the soil type
7. Revised theory suggests carbon dioxide levels already in danger zone
8. Engineer to present leak-proof method for carbon dioxide storage at international conference
9. MIT: Safe storage of greenhouse-gas carbon dioxide
10. Carbon dioxide already in danger zone, warns study
11. ESA tests laser to measure atmospheric carbon dioxide
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Inhaling nitric oxide eases pain crises in sickle cell patients
(Date:5/16/2016)... YORK , May 16, 2016   EyeLock ... solutions, today announced the opening of an IoT Center ... to strengthen and expand the development of embedded iris ... an unprecedented level of convenience and security with unmatched ... authenticate one,s identity aside from DNA. EyeLock,s platform uses ...
(Date:5/3/2016)... 3, 2016  Neurotechnology, a provider of high-precision ... Automated Biometric Identification System (ABIS) , a complete ... MegaMatcher ABIS can process multiple complex biometric transactions ... of fingerprint, face or iris biometrics. It leverages ... and MegaMatcher Accelerator , which have been ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
(Date:6/23/2016)... ... ... STACS DNA Inc., the sample tracking software company, today announced that Dr. ... STACS DNA as a Field Application Specialist. , “I am thrilled that Dr. ... STACS DNA. “In further expanding our capacity as a scientific integrator, Hays brings a ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
Breaking Biology Technology: