Navigation Links
Ingredient in turmeric spice when combined with anti-nausea drug kills cancer cells
Date:8/20/2013

In a laboratory, preclinical study recently published by the journal Organic & Biomolecular Chemistry, Virginia Commonwealth University Massey Cancer Center researchers combined structural features from anti-nausea drug thalidomide with common kitchen spice turmeric to create hybrid molecules that effectively kill multiple myeloma cells.

Thalidomide was first introduced in the 1950s as an anti-nausea medication to help control morning sickness, but was later taken off the shelves in 1962 because it was found to cause birth defects. In the late 1990's the drug was re-introduced as a stand-alone or combination treatment for multiple myeloma. Turmeric, an ancient spice grown in India and other tropical regions of Asia, has a long history of use in herbal remedies and has recently been studied as a means to prevent and treat cancer, arthritis and Alzheimer's disease. According to the American Cancer Society, laboratory studies have shown that curcumin, an active ingredient in turmeric, interferes with several important molecular pathways and inhibits the formation of cancer-causing enzymes in rodents.

"Although thalidomide disturbs the microenvironment of tumor cells in bone marrow, it disintegrates in the body. Curcumin, also active against cancers, is limited by its poor water solubility. But the combination of thalidomide and curcumin in the hybrid molecules enhances both the cytotoxicity and solubility," says the study's lead researcher Shijun Zhang, assistant professor in the Department of Medicinal Chemistry at the VCU School of Pharmacy.

Compared to mixing multiple drugs, creating hybrid molecules can provide certain advantages. "Enhanced potency, reduced risk of developing drug resistance, improved pharmacokinetic properties, reduced cost and improved patient compliance are just a few of those advantages," says another of the study's researchers Steven Grant, M.D., Shirley Carter Olsson and Sture Gordon Olsson Chair in On
'/>"/>

Contact: Alaina Farrish
akfarrish@vcu.edu
804-628-4578
Virginia Commonwealth University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Hot sauce ingredient reduces beer belly fat as a weight-loss surgery alternative
2. Study sheds new light on importance of human breast milk ingredient
3. New oil spill dispersant made from ingredients in peanut butter, chocolate, ice cream
4. A sip of resveratrol and a full p53: Ingredients for a successful cell death
5. New and revised standards for omega-3s, natural sweeteners and other food ingredients proposed
6. Discoveries suggest icy cosmic start for amino acids and DNA ingredients
7. New DNA test identifies ingredients in foods
8. Recipe for large numbers of stem cells requires only one ingredient, says NIH/Pitt team
9. New technologies and ingredients provide better options for gluten-free eating
10. A greener, more sustainable source of ingredients for widely used plastics
11. Turmeric spices up virus study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2015)... DUBLIN , June 22, 2015 ... has announced the addition of the "Huawei ... Analysis" report to their offering. ... going to the opposite direction than Apple,s and ... innovative fingerprint sensor developed by Fingerprint Cards, a ...
(Date:6/23/2015)... 23, 2015   Valencell, a leader ... of a recent study that illustrates its PerformTek ... during activity. In a study conducted at Valencell,s ... with the Apple Watch against a chest strap ... during activity. The study demonstrated that Valencell,s biometric ...
(Date:6/17/2015)... und GERMANTOWN, Maryland , June 17, ... ®   Produktlinie mit DNA-Tests verbessert den Analyseprozess ... QGEN ; Frankfurt Prime Standard: QIA) hat heute ... der Produktlinie Investigator ® ... eingeführt. Die neuen Kits zur Erstellung genetischer Fingerabdrücke bieten ...
Breaking Biology News(10 mins):Huawei Ascend Mate 7 Fingerprint Sensor - Reverse Costing Analysis 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 2QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 3QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 4QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 5QIAGEN bringt in den USA neue Kits für die forensische DNA-Analyse auf den Markt 6
... genetic and geographic data of the H5N1 avian flu ... They found that multiple strains of the virus originated ... many of the migration routes through which the strains ... strains develop and migrate, health officials can better limit ...
... hold a key to defeating another implacable foe: HIV. ... a drastically weakened rabies virus to ferry HIV-related proteins ... disease. The early evidence shows that the vaccine ?which ... , Reporting April 1, 2007 in the Journal of ...
... squeaky voices, but now helium is also helping people ... at the University of Alberta in Edmonton, Canada have ... oxygen allowed patients with chronic obstructive pulmonary disease (COPD) ... 245 per cent. COPD is a disease of the ...
Cached Biology News:UCI scientists reconstruct migration of avian flu virus 2Jefferson scientists find rabies-based vaccine could be effective against HIV 2Helium helps patients breathe easier 2
(Date:6/30/2015)... ... June 30, 2015 , ... uBiome and OpenBiome ... on mechanics of fecal microbiota transplantation in C. difficile patients. , SAN FRANCISCO, ... patients undergoing fecal microbiota transplantation (FMT) as a treatment for Clostridium difficile infections ...
(Date:6/30/2015)... DIEGO , June 30, 2015  The ... Education in Biosciences (CCE/Bio) and UC San Diego ... fermentation, to be held Aug.  12 – 14, ... ).  This three-day workshop provides an intense exposure ... industrial biotechnology, and is well-suited to biologists, process ...
(Date:6/30/2015)... ... June 30, 2015 , ... Smarter Alloys today announced a ... archwire that allows orthodontists to simultaneously apply different forces to different teeth. The ... “We’re thrilled about taking SmartArch one step closer to commercial availability for orthodontists ...
(Date:6/29/2015)... ... June 29, 2015 , ... The global microfluidics market ... forecast period (2015 to 2020). The market is mainly driven by the rising ... for R&D. However, lack of adequate healthcare and research infrastructure in emerging markets, ...
Breaking Biology Technology:uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5
... Wis. - Tushaus Computer Services , which ... Millennium Design, Inc., a provider of Apple products and ... PCs and Macs, but also intellectual property and technology ... organizations. Financial terms of the deal were not disclosed. ...
... - The latest piece of the University of ... is in place. With the help of two corporate sponsors, ... fund-raising arm designed to promote technology transfer. , ,The foundation, ... has received $1 million in seed funding from both ...
... It's not too early to gauge the level of ... company formed by Beth Donley and University of ... already is rubbing elbows with interested investors, particularly angels, ... for eventually attracting big dollars from venture capitalists involves ...
Cached Biology Technology:UWM launches research foundation 2UW scientist, former WiCell director found stem cell company 2UW scientist, former WiCell director found stem cell company 3
...
... trays and universal trays make vessel ... Shaking speed: 40 - ... amplitude Clamps for Erlenmeyer ... including Fernbach flasks Hinged ...
... convenient, and efficient Denatured protein concentration following ... spin column to make handling easy. The ... which were electro-eluted in their Denatured condition. ... high binding capacity fo all pH values. ...
In Western blotting antibodies recognize 94 K protein band, which corresponds to S-layer protein...
Biology Products: