Navigation Links
Ingredient in turmeric spice when combined with anti-nausea drug kills cancer cells
Date:8/20/2013

In a laboratory, preclinical study recently published by the journal Organic & Biomolecular Chemistry, Virginia Commonwealth University Massey Cancer Center researchers combined structural features from anti-nausea drug thalidomide with common kitchen spice turmeric to create hybrid molecules that effectively kill multiple myeloma cells.

Thalidomide was first introduced in the 1950s as an anti-nausea medication to help control morning sickness, but was later taken off the shelves in 1962 because it was found to cause birth defects. In the late 1990's the drug was re-introduced as a stand-alone or combination treatment for multiple myeloma. Turmeric, an ancient spice grown in India and other tropical regions of Asia, has a long history of use in herbal remedies and has recently been studied as a means to prevent and treat cancer, arthritis and Alzheimer's disease. According to the American Cancer Society, laboratory studies have shown that curcumin, an active ingredient in turmeric, interferes with several important molecular pathways and inhibits the formation of cancer-causing enzymes in rodents.

"Although thalidomide disturbs the microenvironment of tumor cells in bone marrow, it disintegrates in the body. Curcumin, also active against cancers, is limited by its poor water solubility. But the combination of thalidomide and curcumin in the hybrid molecules enhances both the cytotoxicity and solubility," says the study's lead researcher Shijun Zhang, assistant professor in the Department of Medicinal Chemistry at the VCU School of Pharmacy.

Compared to mixing multiple drugs, creating hybrid molecules can provide certain advantages. "Enhanced potency, reduced risk of developing drug resistance, improved pharmacokinetic properties, reduced cost and improved patient compliance are just a few of those advantages," says another of the study's researchers Steven Grant, M.D., Shirley Carter Olsson and Sture Gordon Olsson Chair in Oncology Research, associate director for translational research, program co-leader of Developmental Therapeutics and Cancer Cell Signaling research member at VCU Massey Cancer Center.

The hybrid molecules of turmeric and thalidomide created more than 15 compounds, each with a different effect. Scientists found that compounds 5 and 7 exhibited superior cell toxicity compared to curcumin alone or the combination of curcumin and thalidomide. Furthermore, the compounds were found to induce significant multiple myeloma cell death.

"Overall, the combination of the spice and the drug was significantly more potent than either individually, suggesting that this hybrid strategy in drug design could lead to novel compounds with improved biological activities," added Grant. "The results also strongly encourage further optimization of compounds 5 and 7 to develop more potent agents as treatment options for multiple myeloma."


'/>"/>

Contact: Alaina Farrish
akfarrish@vcu.edu
804-628-4578
Virginia Commonwealth University
Source:Eurekalert

Related biology news :

1. Hot sauce ingredient reduces beer belly fat as a weight-loss surgery alternative
2. Study sheds new light on importance of human breast milk ingredient
3. New oil spill dispersant made from ingredients in peanut butter, chocolate, ice cream
4. A sip of resveratrol and a full p53: Ingredients for a successful cell death
5. New and revised standards for omega-3s, natural sweeteners and other food ingredients proposed
6. Discoveries suggest icy cosmic start for amino acids and DNA ingredients
7. New DNA test identifies ingredients in foods
8. Recipe for large numbers of stem cells requires only one ingredient, says NIH/Pitt team
9. New technologies and ingredients provide better options for gluten-free eating
10. A greener, more sustainable source of ingredients for widely used plastics
11. Turmeric spices up virus study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/28/2016)... SAN FRANCISCO and BANGALORE, India ... part of EdgeVerve Systems, a product subsidiary of Infosys (NYSE: ... service provider, today announced a global partnership that ... convenient way to use mobile banking and payment services. ... Mobility is a key innovation area for financial services, but ...
(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... provide their customers enhanced security to access and ...
(Date:4/19/2016)... 2016 The new GEZE SecuLogic ... web-based "all-in-one" system solution for all door components. It ... the door interface with integration authorization management system, and ... The minimal dimensions of the access control and the ... installations offer considerable freedom of design with regard to ...
Breaking Biology News(10 mins):
(Date:5/31/2016)... ... 31, 2016 , ... The Academy of Model Aeronautics is thrilled to announce ... Memorial Day through Labor Day 2016. Bill Chaffee’s Boeing P-12B will be exhibited thanks ... Chaffee won first place for Senior Scale Model at the 1930 National Airplane Model ...
(Date:5/27/2016)... ... May 27, 2016 , ... PBI-Gordon Corporation is pleased to announce Dave ... In his 15-year career with PBI-Gordon, Dave has served in a wide variety of ... in the development and launch of many of PBI-Gordon’s most successful products. , “Dave ...
(Date:5/27/2016)... 27, 2016 At present, the Biotech ... this space know that volatility is what makes this industry ... ActiveWallSt.com: Synta Pharmaceuticals Corp. (NASDAQ: SNTA ), CTI ... LPTN ), and Heat Biologics Inc. (NASDAQ: ... the technical alerts for these stocks at: ...
(Date:5/26/2016)... 26, 2016 Q BioMed Inc. (OTCQB: ... be a featured presenter at the 5th Annual Marcum MicroCap ... York City at the Grand Hyatt Hotel. ... BioMed Inc. CEO, is scheduled to begin at 11a.m ET ... business strategy, recent developments and outline milestones for the balance ...
Breaking Biology Technology: