Navigation Links
Ingredient in soap points toward new drugs for infection that affects 2 billion
Date:9/22/2010

The antibacterial ingredient in some soaps, toothpastes, odor-fighting socks, and even computer keyboards is pointing scientists toward a long-sought new treatment for a parasitic disease that affects almost two billion people. Their report on how triclosan became the guiding light for future development of drugs for toxoplasmosis appears in ACS' monthly Journal of Medicinal Chemistry.

In the study, Rima McLeod and colleagues point out that toxoplasmosis is one of the world's most common parasitic infections, affecting about one-third of the world population, including 80 percent of the population of Brazil. People can catch the infection, spread by the parasite Toxoplasma gondii (T. gondii), from contact with feces from infected cats, eating raw or undercooked meat, and in other ways. Many have no symptoms because their immune systems keep the infection under control and the parasite remains inactive. But it can cause eye damage and other problems, even becoming life threatening in individuals with immune systems weakened by certain medications and diseases like HIV infection, which allow the parasite to become active again, and in some persons without immune compromise. Most current treatments have some potentially harmful side effects and none of them attack the parasite in its inactive stage.

The scientists knew from past research that triclosan has a powerful effect in blocking the action of a key enzyme that T. gondii uses to live. Triclosan, however, cannot be used as a medication because it does not dissolve in the blood. The scientists describe using triclosan's molecular structure as the model for developing other potential medications, including some that show promise as more effective treatments for the disease.


'/>"/>

Contact: Michael Bernstein
m_bernstein@acs.org
202-872-6042
American Chemical Society
Source:Eurekalert

Page: 1

Related biology news :

1. Honey as an antibiotic: Scientists identify a secret ingredient in honey that kills bacteria
2. U of Minn. study finds rising levels of dioxins from common soap ingredient in Mississippi River
3. Creating new healthy ingredients by innovative milling techniques and processes for cereal grains
4. Quality of medicines and food ingredients the focus at USP 2009 Annual Scientific Meeting
5. Proteomics: Finding the key ingredients of disease
6. IVCC and Syngenta start project for novel insecticidal active ingredient for malaria control
7. Common fragrance ingredients in shampoos and conditioners are frequent causes of eczema
8. Princeton-led team finds secret ingredient for the health of tropical rainforests
9. Spotlight on cosmetic ingredients conference
10. Global Rainmakers Appoints James M. Demitrieus as Chief Operating Officer
11. Lupus Research Institute-funded study points to increased risk for lupus in men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... stressed they are often grouchy, grumpy, nasty, distracted or ... EPFL have just highlighted a fundamental synaptic mechanism that ... of social skills and cognitive impairment. When triggered by ... the brain. This was revealed by a work published ... team went to look for answers in a region ...
(Date:9/18/2014)... in the protective tentacles of host anemones, but new ... of kilometres across the open ocean. Although the process ... this is the first time that the high level ... , Dr Steve Simpson, Senior Lecturer in Marine Biology ... colleagues from the Australian Research Council Centre of Excellence ...
(Date:9/17/2014)... doctoral student have designed a device based on a ... and dew., The device could provide water in drought-stricken ... Cheng Luo, professor in the Mechanical & Aerospace Engineering ... College of Engineering department, published "Bioinspired Plate-Based Fog Collectors" ... Society) Applied Materials & Interfaces ...
Breaking Biology News(10 mins):How stress tears us apart 2Expedition finds Nemo can travel great distances to connect populations 2Expedition finds Nemo can travel great distances to connect populations 3Shorebird's beak inspires UT Arlington research on water collection 2
... mothers than duller birds, according to a new study led ... see ultra-violet (UV) light. While the crown of a blue ... has the added dimension of appearing UV-reflectant. , The three-year ... University of California Davis, USA and the University of Glasgow, ...
... Dartmouth researchers has uncovered a protein that plays a vital ... key step in improving the production and quality of crops ... journal PNAS . The team included researchers ... Lausanne. Plant roots use their endodermis, or inner skin, ...
... stem cells and DNA-cutting protein from meningitis bacteria, researchers ... have created an efficient way to target and repair ... Aug. 12, 2013) in the Proceedings of the ... the novel technique is much simpler than previous methods ...
Cached Biology News:Bright birds make good mothers 2New gene repair technique promises advances in regenerative medicine 2
(Date:9/19/2014)... NEW YORK , Sept. 19, 2014  An ... common forms of inherited neuropathies – Charcot-Marie-Tooth disease (CMT) ... feet and legs, causing extreme muscle atrophy, weakness, and ... in the US and millions worldwide. CMT is a ... use of their legs, requiring mobility devices such as ...
(Date:9/19/2014)... (PRWEB) September 19, 2014 Barnhardt ... Product Label for its Organic Cotton . The ... amount of renewable biobased ingredients meets or exceeds levels ... materials composed in whole or in significant part of ... will allow our Organic cotton to be immediately identified ...
(Date:9/18/2014)... USA (PRWEB) September 18, 2014 Bipartisan ... of a bill designed to stimulate development and commercialization ... is being praised by leaders of SPIE, the ... the Revitalizing American Manufacturing and Innovation (RAMI) Act, now ... bill’s authors have said they are optimistic that it ...
(Date:9/18/2014)... Sept. 18, 2014  Health Enhancement Products, Inc. (OTCQB: HEPI), ... algae bioactive compounds and metabolic processes, is pleased to announce ... of directors. Ms. Nola E. Masterson , a ... the board effective September 17, 2014. "We,re ... join our board," states Andrew Dahl , President and ...
Breaking Biology Technology:September is Charcot-Marie-Tooth (CMT) Awareness Month - Scheduled events, activities and important partnerships announced throughout the month! 2Barnhardt Manufacturing Company Earns USDA Certified Biobased Product Certification and Label for Organic Cotton 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Health Enhancement Announces New Board Member In Advance Of Annual Shareholder Meeting 2
... MONTREAL , Feb. 1 /PRNewswire-FirstCall/ - ICBS Ltd. (OTCPK: ... TOGS(TM) 3000 bio-photonic incubation & detection systems, which the company will ... 100% accuracy in the detection of Total Coli forms and E. ... to introduce the new TOGS(TM) 3000 in the U.S, and overseas." ...
... The ... as a regulatory consultant after retiring from Eli Lilly & Co. Dr. ... human pharmaceutical products, including director of regulatory affairs and clinical research. Dr. ... submissions. , ...
... Data Demonstrating a 35% Overall Response Rate with a ... Relapsed or Relapsed/Refractory Waldenstrom,s Macroglobulinemia to be Published in ... Journal of Clinical Cancer Research , QUÉBEC CITY, ... AEZS ; TSX: AEZ) (the "Company"), a late-stage ...
Cached Biology Technology:BioSpec Global Solutions Inc, takes delivery of new TOG's 3000 Home edition for the U.S. and international markets 2Michael Langley, DVM, MBA, RAC Joins the Anson Group as a Regulatory Consultant 2Æterna Zentaris Partner Keryx Announces Positive Phase 2 Results for Perifosine as a Single Agent for the Treatment of Advanced Waldenstrom's Macroglobulinemia 2Æterna Zentaris Partner Keryx Announces Positive Phase 2 Results for Perifosine as a Single Agent for the Treatment of Advanced Waldenstrom's Macroglobulinemia 3Æterna Zentaris Partner Keryx Announces Positive Phase 2 Results for Perifosine as a Single Agent for the Treatment of Advanced Waldenstrom's Macroglobulinemia 4Æterna Zentaris Partner Keryx Announces Positive Phase 2 Results for Perifosine as a Single Agent for the Treatment of Advanced Waldenstrom's Macroglobulinemia 5
Imject Freund's Incomplete Adjuvant (FIA)...
... to slightly cloudy liquid. Yellow, oily, ... set, each containing 10 ml of ... following proportions by weight: 85% Drakeol ... emulsifier), and 0.1% Mycobacterium butyricum ...
... Although there have been many modifications to ... defined media, salt solutions still play an important ... to maintain the pH and osmotic balance in ... water and essential inorganic ions, is as valuable ...
Request Info...
Biology Products: