Navigation Links
Influenza vaccine causes weaker immune response for children of rural Gabon than in semi-urban areas
Date:10/22/2007

Researchers have found that vaccination against influenza strains seem to be more effective in a semi-urban population than in a rural population of schoolchildren in Gabon, Africa, according to an article in the Journal of Infectious Diseases, published by the University of Chicago Press in partnership with the Infectious Diseases Society of America.

The study is one of eight that will be presented and webcast live from the National Institutes of Health on October 22, 2007 as part of the launch of the Council of Science Editors' Global Theme Issue on Poverty and Human Development. The live stream is available beginning at 10 a.m. ET at: http://videocast.nih.gov/summary.asp?live=6239.

Lead author E. van Riet (Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands) and a team of researchers analyzed antibody and cellular responses to influenza A and B strains in 33 children from a semi-urban school in Lambarn in Gabon, Africa, and 22 children from a rural area nearby.

The group found that H1N1, H3N2 and B influenza virus-specific antibodies were already present in the majority of sera before vaccination indicating that influenza strains have already been circulating in Gabon. With little information available about influenza in Africa, the findings of this study indicate that the presence of the virus has probably been underestimated.

Children in the two areas differed with respect to the rates of parasitic infections (higher in rural areas), as well as nutritional status (poorer in rural areas). Following vaccination, influenza virus HI antibody titers increased in both the rural and the semi-urban schoolchildren, but reached significantly higher levels in the semi-urban schoolchildren. The highest titers were seen in semi-urban children not infected with helminths.

Influenza specific IL-10, TNF-alfa, and IFN-gamma responses were higher in the semi-urban children, whereas IL-5 responses were higher in the rural children , indicating a skewing toward Th2 responses in the rural children may, at least partly, be the result of the immune-modulating effects of helminths, says van Riet.

These studies indicate for the first time that influenza virus infections are frequent in Gabon, and suggest that many cases of febrile illness incorrectly diagnosed and mistreated as malaria may actually be due to influenza. In addition, these studies suggest that influenza vaccination will be less effective in rural children than in their semi-urban counterparts, likely because of co-infection with parasites and/or poor nutrition. Closer attention to nutrition and concomitant infections may profoundly affect responses to pandemic influenza and influenza vaccines in developing countries.

With the current attention to the pandemic threat of avian influenza viruses, its global spread, and the preparation of preventive and curative vaccines, it is important to start asking what the immunological consequences of influenza vaccine are in African populations, says van Riet.

The researchers noted that epidemiological data on influenza, as well as on immune responses to vaccination, will be critical for proper management of influenza epidemics in Africa. In addition, improving diagnoses of influenza, and distinguishing it from diseases with similar symptoms such as malaria, will have important implications for medication dosages.


'/>"/>

Contact: Amy Jenkins
amy@jenkinspublicrelations.com
312-836-0613
University of Chicago Press Journals
Source:Eurekalert

Related biology news :

1. Computers to be used to find blueprint for new influenza drug
2. Influenza vaccine uses insect cells to speed development
3. Drug resistant avian influenza viruses more common in Southeast Asia than North America
4. Genome Sequence for Haemophilus Influenzae Completed
5. Less virulent strains of avian influenza can infect humans
6. Confronting Influenza: Are We Prepared?
7. New vaccine platform may fight infections with causes from influenza to bioterrorism
8. First big influenza genome study reveals flu evolution
9. Web model of influenza-host lifecycles will aid scientists in creating anti-viral drugs
10. New influenza vaccine takes weeks to mass produce
11. Study outlines genetic differences between potential pandemic influenza strains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2016)... , PROVO and ... -- Newborn Screening Ontario (NSO), which operates the highest ... for molecular testing, and Tute Genomics and UNIConnect, leaders ... technology respectively, today announced the launch of a project ... sequencing (NGS) testing panel. NSO has ...
(Date:3/18/2016)... , March 18, 2016 --> ... of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and ... security companies in the border security market and the continuing ... and Europe has led visiongain to ... improved success. --> defence & security companies ...
(Date:3/15/2016)... , March 15, 2016 --> ... published by Transparency Market Research "Digital Door Lock Systems Market ... 2015 - 2023," the global digital door lock systems market ... in 2014 and is forecast to grow at a CAGR ... micro, small and medium enterprises (MSMEs) across the world and ...
Breaking Biology News(10 mins):
(Date:5/27/2016)... ... 27, 2016 , ... PBI-Gordon Corporation is pleased to announce Dave Loecke has ... 15-year career with PBI-Gordon, Dave has served in a wide variety of roles. His ... development and launch of many of PBI-Gordon’s most successful products. , “Dave has been ...
(Date:5/26/2016)... LINDEN, Mich. , May 26, 2016  Agriculture ... Des Moines, Iowa is running ... in Lake Erie and coastal ... is key to preventing this widespread issue. ... Michigan,s Upper Peninsula, developed a new, easy ...
(Date:5/26/2016)... ... May 26, 2016 , ... ... Medistem Panama Inc. at the City of Knowledge in Panama, a ... stem cells in the US earlier this year following FDA approval of a ...
(Date:5/25/2016)... ... May 25, 2016 , ... Thailand’s Board of ... 2016 in San Francisco. Located at booth number 7301, representatives from the Thai ... and discuss the Thai biotechnology and life sciences sector. , Deputy Secretary ...
Breaking Biology Technology: