Navigation Links
Influenza study: Meet virus' new enemy
Date:2/21/2013

Simon Fraser University virologist Masahiro Niikura and his doctoral student Nicole Bance are among an international group of scientists that has discovered a new class of molecular compounds capable of killing the influenza virus.

Working on the premise that too much of a good thing can be a killer, the scientists have advanced previous researchers' methods of manipulating an enzyme that is key to how influenza replicates and spreads.

Their new compounds will lead to a new generation of anti-influenza drugs that the virus' strains can't adapt to, and resist, as easily as they do Tamiful. It's an anti-influenza drug that is becoming less effective against the constantly mutating flu virus.

These increasingly less adequate anti-influenza drugs are currently doctors' best weapons against influenza. They helped the world beat H1N1, swine flu, into submission four years ago.

The journal Science Express has just published online the scientists' study, revealing how to use their newly discovered compounds to interrupt the enzyme neuraminidase's facilitation of influenza's spread.

Tamiful and another anti-influenza drug, Relenza, focus on interrupting neuraminidase's ability to help influenza detach from an infected cell's surface by digesting sialic acid, a sugar on the surface of the cell. The flu virus uses the same sugar to stick to the cell while invading it. Once attached, influenza can invade the cell and replicate. v

This is where the newly discovered compounds come to the still-healthy cells' rescue. They clog up neuraminidase, stopping the enzyme from dissolving the sialic acid, which prevents the virus from escaping the infected cell and spreading.

The new compounds are also more effective because they're water-soluble. "They reach the patient's throat where the flu virus is replicating after being taken orally," says Niikura, a Faculty of Health Sciences associate professor.

"Influenza develops resistance to Replenza less frequently, but it's not the drug of choice like Tamiful because it's not water-soluble and has to be taken as a nasal spray.

"Our new compounds are structurally more similar to sialic acid than Tamiful. We expect this closer match will make it much more difficult for influenza to adapt to new drugs."

Ultimately, the new compounds will buy scientists more time to develop new vaccines for emerging strains of influenza that are resistant to existing vaccines.


'/>"/>

Contact: Carol Thorbes
cthorbes@sfu.ca
Simon Fraser University
Source:Eurekalert

Related biology news :

1. Target for potent first-strike influenza drugs identified
2. Climate change could increase levels of avian influenza in wild birds
3. Harnessing anticancer drugs for the future fight against influenza
4. Influenza research: Can dynamic mapping reveal clues about seasonality?
5. Pandemic controversies: The global response to pandemic influenza must change
6. BYU study: Using a gun in bear encounters doesnt make you safer
7. 15-year study: When it comes to creating wetlands, Mother Nature is in charge
8. Study: Exercise can lead to female orgasm, sexual pleasure
9. U of I study: Lose body weight before gaining baby weight
10. Study: Men who do load-bearing exercise in early 20s may be shielded from osteoporosis
11. USF study: Common fungicide wreaks havoc on freshwater ecosystems
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... , Feb. 2, 2016   Parabon ... from the U.S. Army Research Office and the ... range and sensitivity of the company,s Snapshot ... Accounting Mission and, more generally, defense-related DNA forensics. ... phenotyping capabilities (predicting appearance and ancestry from DNA ...
(Date:2/1/2016)... , Feb. 1, 2016  Today, the first ... (AHA) announced plans to develop a first of its ... power of IBM Watson. In the first application of ... IBM (NYSE: IBM ), and Welltok will create ... health assessments with cognitive analytics, delivered on Welltok,s health ...
(Date:1/27/2016)... 2016  Rite Track, Inc. a leading semiconductor equipment ... Chester, Ohio announced today the acquisition of PLUS ... in Austin, Texas , will significantly ... modifications, installations and technical support offerings for TEL Track ... commented, "PLUS has provided world class service including refurbishment, ...
Breaking Biology News(10 mins):
(Date:2/3/2016)...  Today, Symphony Technology Group (STG) announced the closing ... provider of primary research and analytics-based insight for biopharmaceutical ... a global information and technology services company serving the ... be integrated into IMS Health to form a foundation ... ...
(Date:2/3/2016)... ... February 03, 2016 , ... Data ... new solutions focused on social housing of small animal models in research studies. ... data.¹, ² , DSI’s HD-S11 implant has evolved to allow researchers to simultaneously ...
(Date:2/3/2016)... ... February 03, 2016 , ... Big games come and go, ... so much for our country. CereScan, a nationally recognized brain diagnostics and technology company, ... Amputee Football Team (WWAFT) vs. NFL Stars Flag Football Game on February 6, 2016. ...
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 /PRNewswire/ ... specific clusters of commensal, symbiotic and pathogenic microorganisms ... the human body. The human microbiome is involved ... a healthy life. Majority of the microorganisms benefit ... would otherwise not possess. These include metabolism of ...
Breaking Biology Technology: