Navigation Links
Inflammatory on and off switch identified for allergic asthma and COPD
Date:8/1/2013

Bethesda, MDJapanese researchers have made a new step toward understanding whyand how to stoprunaway inflammation for both chronic obstructive pulmonary disorder (COPD) and allergic asthma. In a new report appearing in the August 2013 issue of The FASEB Journal scientists show that two receptors of an inflammatory molecule, called "leukotriene B4," play opposing roles in turning inflammation on and off for allergic asthma and COPD. The first receptor, called "BLT1," promotes inflammation, while the second receptor, called "BLT2," has a potential to weaken inflammation during an allergic reaction. This discovery also is important because until now, BLT2 was believed to increase inflammatory reaction.

"Leukotriene B4 levels are elevated in the airways of the patients with asthma and COPD, and the opposite role of BLT1 and BLT2 in allergic inflammation implies that drug development should target BLT1 and BLT2 differently," said Hiromasa Inoue, M.D., study author from the Department of Pulmonary Medicine at the Graduate School of Medical and Dental Sciences at Kagoshima University in Kagoshima, Japan. "We hope that better anti-asthma drugs or anti-COPD drugs will be produced in the future to treat millions of patients who suffer from severe asthma and COPD."

To make this discovery, scientists compared the allergic reactions in BLT2-gene deleted mice to those in normal mice. Then an allergic asthma reaction was provoked by inhalation of allergens. BLT2-gene deleted mice showed more inflammatory cells in the lung compared to normal mice. Without the BLT2 gene, lung allergic inflammation was stronger than that of normal mice. The production of interleukin-13, an important mediator of allergic inflammation from T lymphocytes, was increased in the group without the BLT2 gene. Results suggest that targeting these two receptors differently and/or separately could achieve vastly different outco
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related biology news :

1. The Japanese traditional therapy, honokiol, blocks key protein in inflammatory brain damage
2. BUSM researchers identify key regulator of inflammatory response
3. Invisible helpers: How probiotic bacteria protect against inflammatory bowel diseases
4. Scientists discover new inflammatory target
5. Researchers say tart cherries have the highest anti-inflammatory content of any food
6. Controlling inflammatory and immune responses
7. Scientists discover molecular link between circadian clock disturbances and inflammatory diseases
8. Promising new drug target for inflammatory lung diseases
9. Quantum dots deliver Vitamin D to tumors for possible inflammatory breast cancer treatment
10. New research examines connection between inflammatory stimulus and Parkinsons disease
11. Scientists discover switch in plants to create flowers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/30/2015)... Mar. 26, 2015 Research and Markets ... "Global Gesture Recognition Market in Automotive Sector 2014-2018" ... forecast the Global Gesture Recognition market in Automotive Sector ... period 2013-2018. Gesture recognition is the ability ... gestures of an individual. Gesture recognition technology can be ...
(Date:3/24/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) has ... Global Strategic Business Report" report to their offering. ... in US$ Thousands by the following Segments: Face Biometrics, and Voice ... Canada , Japan , ... East & Africa , and ...
(Date:3/23/2015)... March 23, 2015 SoundView Technology Group issues a ... NXTD ) Wocket smart wallet. SoundView was one of the ... their experience with the Wocket in multiple scenarios and outlets. ... Foods and other retailers, making both debit and credit card ... also says, "If the company meets their plans in 2015, ...
Breaking Biology News(10 mins):Global Gesture Recognition Market in Automotive Sector Report 2015 - Growing Number of Partnerships 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 2Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 3Technology Research Note Update from SoundView; Real-World Usage and Feedback of Wocket Smart Wallet at CVS, Whole Foods and other Retailers 4
... for Science Writings at Stevens Institute of Technology will host ... a talk by Bernd Heinrich, on Wednesday, April 1, 2009. ... 122, from 4 p.m. to 5:30 p.m. The journalist ... naturalist writer; he,s a great writer, period." A professor emeritus ...
... 2009. No single decision-support system exists for selecting ... recently released report on management after fire hinges upon. ... Western North America, tells us that the type of ... change an area after a wildfire. The authors, however, ...
... therapy of cancer can be improved to be much more ... University Medical Center,s Lombardi Comprehensive Cancer Center in the March ... that antibody therapy has the capacity to immunize people against ... at GUMC and an internationally recognized expert in development and ...
Cached Biology News:Research synthesis shines light on several management options after fires in diverse ecosystems 2Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer 2Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer 3
(Date:4/16/2015)... (PRWEB) April 16, 2015 The ... that the prestigious 2015 Borlaug CAST Communication Award ... member at Tuskegee University in Alabama. Award nominees ... material; public presentations; and/or the use of television, ... all three areas. As a specialist in the ...
(Date:4/16/2015)... 2015 ChemRar High ... and R&D group, and Lancet, Russian Distribution ... and commercialization of new medicines in ... to stimulate the innovative development of the ... http://photos.prnewswire.com/prnh/20150416/739742-a) ,     (Logo: http://photos.prnewswire.com/prnh/20150416/739742-b) , ...
(Date:4/16/2015)... ROCKLAND, Mass. , April 16, 2015 /PRNewswire/ ... of Merck KGaA, Darmstadt, Germany ... Senior Vice President, Head of Global Clinical Development. ... development expertise, including experience in Oncology and Immunology. ... leadership ability, having served as a Vice President ...
(Date:4/16/2015)... 2015 Dana-Farber Cancer Institute and ... Resolution Bioscience, Inc. today announced the successful completion ... blood-based, clinic ready, Next Generation Sequencing (NGS) assay ... is the first to demonstrate the successful sequencing ... in blinded plasma samples and highlights the ability ...
Breaking Biology Technology:The 2015 Borlaug CAST Communication Award Goes to Channapatna Prakash 2Lancet and ChemRar High Tech Center Have Announced a Partnership in the Development and Production of Novel Drugs in Russia 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 2Alise Reicin Joins the Biopharmaceutical Business of Merck KGaA, Darmstadt, Germany as Head of Global Clinical Development 3Resolution Bioscience announces successful collaboration on a novel, non-invasive, targeted NGS test for lung cancer 2Resolution Bioscience announces successful collaboration on a novel, non-invasive, targeted NGS test for lung cancer 3
... SAN FRANCISCO, Nov. 8 Jennerex, Inc. today announced,the ... to the Chairman and,to The President & CEO, and ... Corporate Strategy. Bob Ingram is Vice Chairman, Pharmaceuticals ... Chief Operating Officer,and President of Pharmaceutical operations for Glaxo ...
... Nov. 7 Medarex, Inc.,(Nasdaq: MEDX ) today ... company,s Board of Directors to serve as a director ... is President and CEO of Titan Pharmaceutical, Inc., a,biopharmaceutical ... joining Titan in October 2007, he was Head of ...
... ... treatment issues, SAN RAMON, Calif., Nov. 7 ... advisory group,designed to tackle head-on the increasingly complex ethical issues of,infertility medicine ... RSC,s ethics committee, believed to be the second of its kind among,infertility ...
Cached Biology Technology:Jennerex Appoints Bob Ingram Special Advisor and Hires Marty Glick as EVP, Corporate Strategy 2Medarex Announces Election of Marc Rubin as New Board Member 2California IVF Experts Tap Ethics Committee for Guidance 2
Convenient 10X buffer concentrate used to maximize binding to the solid phase in microwell ELISA. Formulated to provide optimal pH and ionic strength for binding of antibodies and some antigens. Co...
A trigger solution for Flashlight labeled materials....
... system holds 48 x 0.2 ml tubes, or a ... fluorescence (470-500 nm) for each well, and a pair ... 540-700 nm). This item is a real-time upgrade for ... are 18 x 32 x 33 cm (W x ...
... Genome-pULSe Kit delivers a novel procedure for ... labeling of whole genome DNA from small ... provide a quick and highly reproducible amplification ... consists of a REPLI-g Mini Kit module ...
Biology Products: