Navigation Links
Inflammation triggers cell fusions that could protect neurons, Stanford research shows
Date:4/20/2008

ted significantly more heterokaryons than we ever had in the past," said Blau, "from fewer than 10 in an entire animal to several hundred." When the researchers looked more closely, they found that those animals with higher-than-expected numbers of fused cells also had an inflammatory skin condition common to aging laboratory mice called idiopathic ulcerative dermatitis. This type of chronic inflammation affects the entire immune system of the animal and causes a systemwide immune response.

The researchers confirmed that the remarkable increase in the numbers of fused cells was related to inflammation by using the traditional radiation/bone marrow transplant approach in mice with dermatitis. Finally, they counted the fused cells that formed in a mouse model of multiple sclerosis - an autoimmune disease characterized by inflammation and damage of the central nervous system. Neurologist and multiple sclerosis specialist Lawrence Steinman, MD, professor of neurology and neurological sciences at the medical school, co-authored the research and provided the mouse model for study. Heterokaryons in some of these mice numbered in the thousands.

Even more intriguing than the inflammation-induced increase in numbers was a cross-species experiment that showed nuclei from rat blood stem cells that had fused to Purkinje cells in mice stop expressing blood cell proteins and begin to express rat neuron-specific gene products. This switch exemplifies a type of genetic reprogramming that has been a source of ongoing debate and great interest in the world of stem cell research. Such reprogramming is critical to the regeneration of functional tissues by stem cells.

"What we're seeing is that this phenomenon is happening in real life," said Blau, who next plans to study whether such fusions can rescue damaged or dying Purkinje neurons. "We don't know yet if this function is beneficial, but we now know that there are sites where it happens at fairly high fre
'/>"/>

Contact: Mitzi Baker
mabaker@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Bleeding, not inflammation, is major cause of early lung infection death
2. St. Louis University scientists identify chemical that triggers Parkinsons disease
3. Agent that triggers immune response in plants is uncovered
4. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
5. Smithsonian scientists find evidence that could rewrite Hawaiis botanical history
6. For some who have lost their sense of smell, a once popular asthma drug could help
7. New fish has a face even Dale Chihuly could love
8. Coral reefs and climate change: Microbes could be the key to coral death
9. Algae could one day be major hydrogen fuel source
10. Specially-designed soils could help combat climate change
11. U-M ballast-free ship could cut costs while blocking aquatic invaders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/21/2014)... in severe abdominal pain, vomiting and systemic inflammation. Every ... with the disease resulting in 1000 deaths. There is ... fluid and nutritional support. , Dr Jason Bruce, ... research, said "The major causes of pancreatitis include bile ... combined with a high fat diet. In fact, the ...
(Date:8/20/2014)... Tennessee, Knoxville, research finds life can persist in a ... part of a team that examined waters and sediments ... sheet and found the extreme environment supports microbial ecosystems. ... Mikucki and her colleagues has implications for life in ... solar system. The findings are published in the current ...
(Date:8/20/2014)... Using population-based screening outcomes of approximately 3 million infants, ... researchers at the University of Massachusetts Medical School, have ... can be successfully implemented across public health newborn screening ... the Aug. 20 issue of the Journal of ... the rate of SCID in newborns is higher than ...
Breaking Biology News(10 mins):Insulin offers new hope for the treatment of acute pancreatitis 2University of Tennessee research uncovers subglacial life beneath Antarctic ice sheet 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 2Newborn screening expansion offers early diagnosis and treatment to infants with SCID 3
... behalf of the European Pet Food Industry Federation (FEDIAF), ... consumption for puppies. The research marks a significant step ... A levels for puppies and sheds new light on ... conducted by scientists from the Free University of Berlin ...
... during the Dust Bowl what a disastrous impact wind ... study has uncovered a less obvious, but still troubling, ... soil particles, but also the beneficial microbes that help ... a powerful DNA sequencing technique, called pyrosequencing, a team ...
... turbine and a meteorological tower recently erected on the ... visible symbol of the University,s commitment to establish a ... Robert Nelson, professors of aerospace and mechanical engineering, are ... Laboratory for Enhanced Wind Energy Design, titled "eWiND." The ...
Cached Biology News:Collaborative research team identifies safe upper level for vitamin A consumption for puppies 2Agricultural bacteria: Blowing in the wind 2Agricultural bacteria: Blowing in the wind 3EWiND facility aimed at improvements in wind energy 2
(Date:8/20/2014)... nerves in your ear could improve the health of ... the University of Leeds used a standard TENS machine ... electrical pulses to the tragus, the small raised flap ... of the ear canal. , The stimulation changed the ... reducing the nervous signals that can drive failing hearts ...
(Date:8/20/2014)... GraphDB™ 6.0 from ... the enterprise replication cluster, faster loading speeds, higher ... Elasticsearch. This release happens to coincide with a ... GraphDB™ was formerly known as OWLIM. ... enterprise resilient RDF triplestore will also benefit from ...
(Date:8/19/2014)... (PRWEB) August 19, 2014 Shimadzu ... chromatography systems, Prominence-i and Nexera-i, adding to the ... Combining excellent functionality, an intuitive operating environment, and ... a more efficient workflow for conventional to ultra-high-speed ... innovative, intuitive and intelligent design so users can ...
(Date:8/19/2014)... , Aug. 19, 2014 A Geisinger ... been nominated for a Centers for Disease Control and ... a major public health concern. Joseph ... is one of a team of researchers nominated for ... C. Shepard Science Award for Data Methods and Study ...
Breaking Biology Technology:'Tickling' your ear could be good for your heart 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 2Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 3Ontotext Improves Its RDF Triplestore, GraphDB™ 6.0: Enterprise Resilience, Faster Loading Speeds and Connectors to Full-Text Search Engines Top the List of Enhancements 4Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 2Shimadzu’s New i-Series Integrated Liquid Chromatography Systems Provide Laboratories Wider Range of Analytical Capabilities 3Geisinger investigator nominated for federal award 2Geisinger investigator nominated for federal award 3
... N.J., Feb. 24, 2011 Palatin Technologies, Inc. (NYSE Amex: ... underwritten public offering of 23,000,000 units, consisting of 23,000,000 shares ... shares of its common stock and Series B Warrants to ... to the public of $1.00 per unit. Palatin expects that ...
... ) today announced that management will present at the following conferences: ... 2, 2011 at 2:30 p.m. ET RBC Capital Markets, Healthcare Conference, ... Cowen Annual Healthcare Conference, Boston, MA on March 8, 2011 at 11:00 ... on March 14, 2011 at 10:00 a.m. PT ...
... This release is available in German . ... electronics for a long time, and now they are making ... no longer only used in cell phones and digital cameras. ... optical semiconductor chips and is increasingly using them in driver ...
Cached Biology Technology:Palatin Technologies, Inc. Announces Pricing of Public Offering of Common Stock and Warrants 2Palatin Technologies, Inc. Announces Pricing of Public Offering of Common Stock and Warrants 3UV-transparent coating for image sensors 2
Anti-human C5/C5b, Clone 568, Monoclonal Antibody...
Transcription factor Sp2. [Source:Uniprot/SWISSPROT;Acc:Q02086] Antigen: Recombinant Protein Epitope Signature Tag (PrEST)....
Rabbit Anti-melatonin (different linkage) Polyclonal Antibody...
... to Asparagine synthetase ( Abpromise ... Antigen: ... in the C-terminus of Human ... Entrez GeneID: 440 ...
Biology Products: