Navigation Links
Inflammation triggers cell fusions that could protect neurons, Stanford research shows
Date:4/20/2008

gineered to express a green fluorescent protein. The new blood stem cells would then entirely repopulate the animal's now-absent hematopoietic system with green-fluorescing cells whose origin could be easily identified. The researchers could then pick out heterokaryons in the brain by looking for green neurons against a neutral background.

The researchers, in collaboration with scientists at the University of British Columbia in Vancouver, used this technique in the current study to transplant a single hematopoietic stem cell and prove that the heterokaryons in the brain were derived from blood. However, because such high doses of radiation are known to break down the natural barrier that restricts the flow of cells and molecules between the brain and the blood, Blau and her colleagues wondered if this fusion would still occur under less physiologically traumatic conditions.

They used a technique called parabiosis to introduce blood cells expressing green fluorescent protein into an unmodified animal. In parabiosis, two mice are surgically joined in such a way that they share a circulatory system. One mouse had been engineered to express the green protein in all its cells, and one had not. Because the animals shared a blood supply for several weeks, about half of the blood cells in the unmodified mouse expressed the green protein-enough to enable the researchers to detect fused cells in the brain.

The researchers found evidence of fusion between blood cells and Purkinje neurons in this radiation-free system 20 to 26 weeks after surgery. In fact, green heterokaryons were identifiable for up to 20 weeks after the mice were separated, when most of the blood cells in the unmodified mouse had been regenerated as non-colored cells.

But then Johansson saw something surprising. As in previous experiments, most of the mice had very low numbers of fused cells in their cerebellums, but a few had more. Up to 100 times more.

"Clas no
'/>"/>

Contact: Mitzi Baker
mabaker@stanford.edu
650-725-2106
Stanford University Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Bleeding, not inflammation, is major cause of early lung infection death
2. St. Louis University scientists identify chemical that triggers Parkinsons disease
3. Agent that triggers immune response in plants is uncovered
4. Carnegie Mellon scientists investigate initial molecular mechanism that triggers neuronal firing
5. Smithsonian scientists find evidence that could rewrite Hawaiis botanical history
6. For some who have lost their sense of smell, a once popular asthma drug could help
7. New fish has a face even Dale Chihuly could love
8. Coral reefs and climate change: Microbes could be the key to coral death
9. Algae could one day be major hydrogen fuel source
10. Specially-designed soils could help combat climate change
11. U-M ballast-free ship could cut costs while blocking aquatic invaders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... animals often develop relationships with other group members to ... wild chacma baboons the strategy for grooming activities shows ... just published in the scientific journal Biology Letters ... baboons is not practiced without ulterior motives. To be ... the individual, while grooming another individual can provide access ...
(Date:7/11/2014)... University, Sweden, have explored two different ways that ... leading to the formation of oxygen molecules in ... the scientific journal Nature Communications . , ... synthetic catalysts for water oxidation, which are key ... direct storage of solar energy in fuels like ...
(Date:7/11/2014)... 2014 The increased risk of kidney injury related ... fluids reflects the mass of HES molecules, according to ... journal of the International Anesthesia Research Society (IARS). , ... effect of HES on cultured human renal proximal tubule ... Wunder and colleagues of University Hospital Wrzburg, Austria. ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2Molecular snapshots of oxygen formation in photosynthesis 2In lab studies, hydroxyethyl starch has direct harmful effects on kidney cells 2
... mantra of our health-conscious times and is seen as an ... much salt in the diet and specifically sodium ... blood pressure however, scientists have found that salt,s other oft-overlooked ... study by researchers at the University of Glasgow has revealed ...
... for Translational Medicine and Therapeutics, 7th Annual International ... the Science of Scale, to be held in ... to translational science. ITMAT is part of the ... Pennsylvania. , Speakers will include those dealing with ...
... of the Boston Police Department, will ... IEEE International Conference on Technologies for Homeland Security (HST ,13) ... the aftermath of the tragic events of 15 April 2013 ... that ultimately led to the capture of one of the ...
Cached Biology News:Yin-yang effect of sodium and chloride presents salt conundrum 2Lab-on-a-chip tech, brain mapping & microbiome highlighted at translational med meeting 2Boston Police Chief to Address Boston Marathon Bombings at IEEE Homeland Security Conference in Waltham, Mass., on 12 November 2
(Date:7/11/2014)... , July 11, 2014  Researchers have pioneered ... images. The new technology, called Virtual Finger, allows ... structures like neurons and synapses using the flat ... technology makes 3D imaging studies orders of magnitude ... an unprecedented level across many areas of experimental ...
(Date:7/10/2014)... July 10, 2014 Product and ... very low abundance and are often “lost in ... time-consuming. , Join presenters Dr. Rowel Tobias, Senior ... John Anders, Head of Quality at Nanotherapeutics, Inc., ... that can speed detection and quantitation while achieving ...
(Date:7/10/2014)... Mass. (PRWEB) July 10, 2014 Terascala, ... today announced that Alan Swahn, a former vice president ... executive team as vice president of marketing. Terascala’s software ... Dell and NetApp create the highest performance and most ... been appointed to guide Terascala’s channel expansion and broaden ...
(Date:7/10/2014)... OMICS Group’s 5th International conference and exhibition ... at Double Tree by Hilton Beijing, China is all ... & Bioanalytical research methods only to facilitate improved living ... Dr. Srinubabu Gedela, MD of OMICS Group Inc has ... one in bringing a unique and international mix of ...
Breaking Biology Technology:Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 2Virtual Finger Enables Scientists To Navigate And Analyze 3D Images Of Complex Biological Structures 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Terascala Expands Executive Team 2Terascala Expands Executive Team 3A Critical Review of Analytical Techniques for Improved Living Standards 2A Critical Review of Analytical Techniques for Improved Living Standards 3A Critical Review of Analytical Techniques for Improved Living Standards 4
... , ,ROCHESTER, Wis. Runzheimer International ... the formation of an exclusive partnership between the ... travel managers within the Concur Expense solution. , ... in travel programs, policy and cost benchmarking information, ...
... about more than the one that got away , ... fish were MILWAUKEE The Medical College of Wisconsin ... its research. It reached an important milestone July 1, when ... marketing and licensing for MCW's Research Foundation . , ...
... Terrace ,Source: UW Communications MADISON - With the University ... the verge of creating two separate statewide networks, Gov. ... combine their efforts. , ,"It's more sensible for taxpayers ... said Doyle spokesperson Dan Leistikow. , ,Initial discussions last ...
Cached Biology Technology:Runzheimer and Concur develop travel management service 2Interview with Medical College of Wisconsin Research Foundation's new director of marketing and licensing 2Interview with Medical College of Wisconsin Research Foundation's new director of marketing and licensing 3Governor tells state, university to work together on IT 2
Microlite 1+ 1x12 Strip assembled, flat bottom; the ideal vessel for low signal luminescent reactions, offering medium binding with enhanced dynamic range, extra high reflectivity and minimal cross t...
Immulon 4 HBX 1x12 Strip, flat bottom; high binding extra surface with special resin and irradiation, offers maximum protein uptake....
... 0-10 psi precision pressure regulator and pressurized syringe ... Faster liquid-switching Steady flow rate Microinjecting ... Can be added to any new ... any third-party manufacturer, even homemade. Connect to house ...
...
Biology Products: