Navigation Links
Inflammation may link obesity and adverse pregnancy outcomes

Amsterdam, NL -- A number of different immunological mechanisms ensure the successful establishment and maintenance of pregnancy. Imbalance in these mechanisms is associated with adverse pregnancy outcomes. In a review published in Advances in Neuroimmune Biology, researchers from the Institute of Life Science, College of Medicine at Swansea University in the UK examine the impact of maternal obesity on the inflammatory responses in tissues of both the mother and the child.

"While great progress has been made in elucidating the immunological mechanisms that ensure reproductive success, we now need to understand the impact of a very modern epidemic on immune response at the materno-fetal interface, as well on the mother and the child," said lead investigator Catherine A. Thornton, PhD. "Inflammation may have a key role in many of the detrimental effects of obesity in non-pregnant individuals, and emerging data suggest that inflammation also links obesity and adverse pregnancy outcomes."

Evidence of altered inflammatory status with obesity in the circulation of both the mother and child in pregnancy is emerging. For example, obese pregnant women have elevated levels of interleukin-6 (IL-6). IL-6 is also increased in the cord plasma of offspring of obese mothers, and is associated with increased fetal adiposity and, in a rat model, to hypertension and increased hypothalamic-pituitary-adrenal axis activity in adulthood. Altered inflammatory status of the placenta in association with maternal obesity may have a critical role in the short term programming of health and disease in the offspring, the researchers commented. Maternal obesity is associated with an inflammatory response by the placenta including elevated pro-inflammatory cytokine gene expression.

The negative impact of maternal obesity on the immune function of mother and child includes an increased risk for preeclampsia, likely mediated via inflammation and triglycerides. Increased maternal body mass index is associated with an increased risk of neonatal early onset group B streptococcal disease, and an increased risk of respiratory tract infections. The inflammatory response and immune function of the newborn might relate to later health outcomes. Hyper-responsiveness of inflammatory function at birth is linked to the development of allergic disease in infancy.

Maternal metabolic status during pregnancy and weaning is particularly relevant to healthy development of hypothalamic neurones that regulate weight and feeding in offspring, the researchers report. One study demonstrated that a high-fat diet during pregnancy can induce the expression of hypothalamic peptides involved in the regulation of food intake and body composition in weanling rats. More recently, female offspring of fathers fed a chronic high fat diet had impaired glucose tolerance and insulin secretion. "These findings lead to the suggestion that such programmed expression has a role to play in adult physiology, including increased food intake, preference for a fat-rich diet, weight gain, and metabolic dysfunction," says Dr. Thornton.

"Diseases once found only in adults are increasing in the paediatric population. The focus has been on diseases with a clear metabolic component and it remains relatively unknown what risk maternal obesity during pregnancy imposes for the development of autoimmune diseases, allergy and asthma, and neurodevelopment and cognitive behavior," stated Dr. Thornton. "Animal models indicate that the provision of a normal diet to the offspring once weaned does not overcome the effects of maternal overnutrition, so simple dietary changes may prove ineffective. Targeted maternal immunomodulation might be needed to curtail this potential pandemic."

Contact: Daphne Watrin
IOS Press

Related biology news :

1. Novel technique uses RNA interference to block inflammation
2. Blocking inflammation could lead to tailored medical treatments
3. Pitt team finds molecular pathway that leads to inflammation in asthma
4. Blocking common gateway to inflammation suppresses cancer
5. Researchers see a picture of threat in the brain: Work may lead to new model of neuroinflammation
6. BUSM awarded NIH grant to identify role of immune system in chronic inflammation, disease
7. Scientists discover that a specific enzyme inhibitor may help control lung inflammation
8. Study on effects of resveratrol and quercetin on inflammation and insulin resistance
9. BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
10. Researchers discover how natural drug fights inflammation
11. Barrow scientists uncover clues on inflammation in central nervous system
Post Your Comments:
(Date:5/12/2016)... -- , a brand of Troubadour Research ... the Q1 wave of its quarterly wearables survey. A ... to a program where they would receive discounts for ... "We were surprised to see that so ... , CEO of Troubadour Research, "primarily because there are ...
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a ... the MegaMatcher Automated Biometric Identification System (ABIS) ... large-scale multi-biometric projects. MegaMatcher ABIS can process multiple ... using any combination of fingerprint, face or iris ... MegaMatcher SDK and MegaMatcher Accelerator , ...
(Date:4/28/2016)... First quarter 2016:   , Revenues amounted ... quarter of 2015 The gross margin was 49% (27) ... the operating margin was 40% (-13) Earnings per share ... operations was SEK 249.9 M (21.2) , Outlook   ... M. The operating margin for 2016 is estimated to ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Apellis ... Phase 1 clinical trials of its complement C3 ... single and multiple ascending dose studies designed to ... (PD) of subcutaneous injection in healthy adult volunteers. ... (SC) either as a single dose (ranging from ...
(Date:6/23/2016)... 23, 2016 Andrew ... Published recently in ... journal from touchONCOLOGY, Andrew D Zelenetz , ... cancer care is placing an increasing burden on ... biologic therapies. With the patents on many biologics ...
(Date:6/23/2016)... San Francisco, CA (PRWEB) , ... June 23, ... ... capture (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase ... DIA Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting ...
(Date:6/23/2016)... Connecticut (PRWEB) , ... June 23, 2016 , ... ... introduce a new line of intelligent tools designed, tuned and optimized exclusively for ... September 12–17 in Chicago. The result of a collaboration among several companies with ...
Breaking Biology Technology: