Navigation Links
Inflammation may link obesity and adverse pregnancy outcomes
Date:1/10/2012

Amsterdam, NL -- A number of different immunological mechanisms ensure the successful establishment and maintenance of pregnancy. Imbalance in these mechanisms is associated with adverse pregnancy outcomes. In a review published in Advances in Neuroimmune Biology, researchers from the Institute of Life Science, College of Medicine at Swansea University in the UK examine the impact of maternal obesity on the inflammatory responses in tissues of both the mother and the child.

"While great progress has been made in elucidating the immunological mechanisms that ensure reproductive success, we now need to understand the impact of a very modern epidemic on immune response at the materno-fetal interface, as well on the mother and the child," said lead investigator Catherine A. Thornton, PhD. "Inflammation may have a key role in many of the detrimental effects of obesity in non-pregnant individuals, and emerging data suggest that inflammation also links obesity and adverse pregnancy outcomes."

Evidence of altered inflammatory status with obesity in the circulation of both the mother and child in pregnancy is emerging. For example, obese pregnant women have elevated levels of interleukin-6 (IL-6). IL-6 is also increased in the cord plasma of offspring of obese mothers, and is associated with increased fetal adiposity and, in a rat model, to hypertension and increased hypothalamic-pituitary-adrenal axis activity in adulthood. Altered inflammatory status of the placenta in association with maternal obesity may have a critical role in the short term programming of health and disease in the offspring, the researchers commented. Maternal obesity is associated with an inflammatory response by the placenta including elevated pro-inflammatory cytokine gene expression.

The negative impact of maternal obesity on the immune function of mother and child includes an increased risk for preeclampsia, likely mediated via inflammation and triglyc
'/>"/>

Contact: Daphne Watrin
d.watrin@iospress.nl
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related biology news :

1. Novel technique uses RNA interference to block inflammation
2. Blocking inflammation could lead to tailored medical treatments
3. Pitt team finds molecular pathway that leads to inflammation in asthma
4. Blocking common gateway to inflammation suppresses cancer
5. Researchers see a picture of threat in the brain: Work may lead to new model of neuroinflammation
6. BUSM awarded NIH grant to identify role of immune system in chronic inflammation, disease
7. Scientists discover that a specific enzyme inhibitor may help control lung inflammation
8. Study on effects of resveratrol and quercetin on inflammation and insulin resistance
9. BUSM researchers uncover cellular mechanism responsible for chronic inflammation, Type 2 diabetes
10. Researchers discover how natural drug fights inflammation
11. Barrow scientists uncover clues on inflammation in central nervous system
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... news release is available in German . ... key players in the natural nitrogen cycle on Earth ... specialist bacteria were thought to depend on nitrite as ... led by Holger Daims, a microbiologist at the University ... use hydrogen as an alternative source of energy. The ...
(Date:8/29/2014)... The rise of the Tibetan plateau -- the largest ... important for both its profound effect on climate and ... in GSA Bulletin , Katharine Huntington and colleagues ... -- using modern and fossil snail shells to investigate ... Tibet. , Views range widely on the timing ...
(Date:8/28/2014)... This news release is available in German . ... fresh water fish, owes its name to a striking pattern ... cell types, black cells, reflective silvery cells, and yellow cells ... fish and arrange as a multilayered mosaic to compose the ... all three cell types have to interact to form proper ...
Breaking Biology News(10 mins):Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7How the zebrafish gets its stripes 2How the zebrafish gets its stripes 3
... ARBOR, Mich.---Standing out in a crowd is better than ... in a colony where fights between nest-mates determine social ... University of Michigan researchers published online this week in ... be different, to wear a nametag advertising your identity," ...
... Germany, October 15, 2009 / b3c newswire / ... announced today that they will enter into collaboration. ... for the identification of novel biomarkers in a ... phosphoproteomics platform allows annotation and quantification of regulated ...
... have made a discovery that promises to deliver a new ... in all mammals not just humans or another particular ... the biological ,barcodes, of infectious microbes such as food poisoning ... could be made to prevent a particular disease in all ...
Cached Biology News:Being a standout has its benefits, study shows 2KINAXO Biotechnologies and Bayer Vital GmbH Collaborate in Phosphoproteomics Biomarker Identification 2KINAXO Biotechnologies and Bayer Vital GmbH Collaborate in Phosphoproteomics Biomarker Identification 3KINAXO Biotechnologies and Bayer Vital GmbH Collaborate in Phosphoproteomics Biomarker Identification 4Bug barcode readers hold out promise of universal vaccines 2
(Date:8/29/2014)... are based on electrons, but one of the most ... i.e. circuits based on light (photons) instead of electrons. ... a stream of single photons and control their direction. ... attempts to achieve this control, but now scientists at ... steady stream of photons emitted one at a time ...
(Date:8/29/2014)... Pittsburgh, PA (PRWEB) August 29, 2014 ... Chairman, Hub MacDonald, and colleague Koichiro Matsuda, Horiba Scientific, ... JASIS on September 5, 2014. JASIS , Asia’s ... September 3-5, 2014, in Makuhari Messe, Japan. , ... New Tools for Bioanalysis from Single Molecules to Single ...
(Date:8/29/2014)... California (PRWEB) August 29, 2014 ... of Energy's 2014 Hydrogen Production R&D Award ... -- by splitting water using sunlight. , Shared ... (NREL) and the University of Nevada, Las Vegas ... work developing models of photoelectrochemical solar-hydrogen production and ...
(Date:8/29/2014)... August 29, 2014 Intrinsic Imaging, ... certified, GAMP® 5 compliant imaging core lab, announced ... Phase II clinical trial to assess a new ... this trial, Intrinsic Imaging will provide comprehensive imaging ... protocol and charter development, site qualification, site training ...
Breaking Biology Technology:Breakthrough in light sources for new quantum technology 2Fifth Annual U.S. Symposium at JASIS Organized by Pittcon’s Program Chairman Hub MacDonald 2Livermore Team Awarded for Hydrogen Production Research 2Intrinsic Imaging Awarded Phase II Clinical Trial to Assess New Treatment for Non-Hodgkin’s Lymphoma 2
... Its one thing for a dictator to control a ... its quite another for a totalitarian regime to block ... wireless laptop. , ,Perhaps that explains why some global ... Internet away from its American roots and substitute United ...
... Madison, Wis. Wisconsin businesses and individuals are ... New Products Awards Competition, which recognizes benefits coming ... emerging technologies. , ,Governor's New Products Awards ... (1,000 or more employees); large companies (500-999 employees); ...
... Madison Area Technical College's Network Security Specialist degree ... threats to computer systems and data, has earned federal certification ... Systems . , ,It is only one of two in ... MATC had to match its curriculum precisely to what the ...
Cached Biology Technology:Democracy and the Net - How American ideals are quietly influencing the world 2Democracy and the Net - How American ideals are quietly influencing the world 3
... cells for DNA isolation. Designed ... (includes 96 well plate adapters from ... the entire plate length (max capacity ... be used for soil, microorganisms, animal ...
Phospho- (Ser) 14-3-3 Binding Motif (4E2) Mouse mAb...
Rat polyclonal to acetyl Salicylic Acid ( Abpromise for all tested applications)....
Drugs and NO-drug Rat Anti-conjugated Acetyl Salicylic Acid Polyclonal Antibody...
Biology Products: