Navigation Links
Inflammation and cognition in schizophrenia
Date:11/1/2012

Philadelphia, PA, November 1, 2012 There are a growing number of clues that immune and inflammatory mechanisms are important for the biology of schizophrenia. In a new study in Biological Psychiatry, Dr. Mar Fatj-Vilas and colleagues explored the impact of the interleukin-1β gene (IL1β) on brain function alterations associated with schizophrenia.

Fatj-Vilas said that "this study is a contribution to the relatively new field of 'functional imaging genetics' which appears to be potentially powerful for the study of schizophrenia, where genetic factors are of established importance and cognitive impairment affecting particularly executive function and long-term memory is increasingly recognized as a core feature of the disorder."

To conduct this study, they recruited patients with schizophrenia and healthy volunteers, all of whom completed a working memory task while undergoing a functional magnetic resonance imaging scan in the laboratory. This allowed the researchers to determine which areas of the brain became activated during the task. Each participant was also genotyped to determine which allelic combination of the -511C/T polymorphism at the promoter region of the IL1β gene they carry: CC, TT, or CT.

Patients who were homozygous for the C allele (CC) showed reduced prefrontal cortex activation associated with working memory than patients who had at least one copy of the T allele. Among the healthy volunteers, frontal brain activation did not differ according to genotype.

"The analyzed genetic variant exerts an influence on prefrontal cortex function and this influence is different in healthy subjects and patients with schizophrenia," summarized Fatj-Vilas.

An important issue is that the -511C/T seems to have a role in regulating the levels of IL1B expression, in which case it would influence neuronal activity dependent on the protein availability. This means that the T allele has been reported to be more active than the C allele, suggesting that a tendency for greater expression of IL1β is associated with greater compromise of frontal cortical functions underlying cognition.

Interleukin-1β is released in the blood under stressful conditions and its release is one of the ways that stress promotes inflammation. IL-1β levels in the blood are altered, for example, in patients with depression and other neuropsychiatric disorders.

Apart from having a role in the immune system, interleukins are also involved in a variety of developmental and functioning processes of the central nervous system. Thus, this study provides further clues for identifying specific biological mechanisms of the disorder associated with both neurodevelopmental processes and immunological and stress response functions.

Dr. John Krystal, Editor of Biological Psychiatry, commented, "We are just beginning to explore the functional impact of inflammatory mechanisms in schizophrenia and the current findings increase our curiosity about these novel mechanisms."

The article is "Effect of the Interleukin-1β Gene on Dorsolateral Prefrontal Cortex Function in Schizophrenia: A Genetic Neuroimaging Study" by Mar Fatj-Vilas, Edith Pomarol-Clotet, Raymond Salvador, Gemma C. Mont, Jess J. Gomar, Salvador Sarr, Jordi Ortiz-Gil, Candibel Aguirre, Ramn Landn-Romero, Amalia Guerrero-Pedraza, Sergi Papiol, Josep Blanch, Peter J. McKenna, and Lourdes Faans (doi: 10.1016/j.biopsych.2012.04.035). The article appears in Biological Psychiatry, Volume 72, Issue 9 (November 1, 2012), published by Elsevier.


'/>"/>

Contact: Rhiannon Bugno
Biol.Psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Related biology news :

1. Weight loss led to reduction in inflammation
2. Modest alcohol intake associated with less inflammation in patients with common liver disease
3. Intestinal bacteria produce neurotransmitter, could play role in inflammation
4. Omega-3 lowers inflammation in overweight older adults
5. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
6. Chronic inflammation in the brain leads the way to Alzheimers disease
7. Cell receptor has proclivity for T helper 9 cells, airway inflammation
8. A solution to reducing inflammation
9. New research about facial recognition turns common wisdom on its head
10. WSU researchers say genes and vascular risk modify effects of aging on brain and cognition
11. The music of the (hemi)spheres sheds new light on schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/29/2016)... March 29, 2016 LegacyXChange, Inc. ... "LEGX" and SelectaDNA/CSI Protect are pleased to announce our ... in a variety of writing instruments, ensuring athletes signatures ... created collectibles from athletes on LegacyXChange will be assured ... the DNA. Bill Bollander , CEO ...
(Date:3/22/2016)... Ontario , PROVO and ... Newborn Screening Ontario (NSO), which operates the ... for molecular testing, and Tute Genomics and UNIConnect, ... management technology respectively, today announced the launch of a ... next-generation sequencing (NGS) testing panel. NSO ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... May 23, 2016 , ... RoviSys, a leading ... in Aurora, Ohio, has broken ground on a new building in Holly Springs, ... area, this new location solidifies a commitment to business in the region. The ...
(Date:5/20/2016)... ... , ... The leading Regenerative Veterinary Medicine Company, VetStem Biopharma ., is ... 100 of their own patients with the VetStem Cell Therapy. Each of these veterinarians ... their patients. , The veterinarians are Dr Ross Rich former owner of Cave ...
(Date:5/20/2016)... ... 20, 2016 , ... The recent recall by Costco and Trader Joes of ... on May 12, 2016(1), demonstrates the need for faster and more cost effective bio-threat ... PathSensors, Inc. , PathSensor’s latest solution uses a biosensor technology called ...
(Date:5/19/2016)... 2016 There is no saying ... the relentless pressures in pricing and lack in consumer ... circle though - numerous opportunities are up for grabs ... ActiveWallSt.com,s presents four names in this sector: Portola Pharmaceuticals ... (NASDAQ: VTAE ), Anthera Pharmaceuticals Inc. (NASDAQ: ...
Breaking Biology Technology: