Navigation Links
Infiltrating cancer's recruitment center
Date:1/26/2011

Tel Aviv The most common connective tissue cell in animals is the fibroblast, which plays an important role in healing wounds. But Dr. Neta Erez of Tel Aviv University's Sackler Faculty of Medicine has now demonstrated that fibroblasts can also do a body great harm, helping to "recruit" immune cells for tumor growth.

At the onset of a tumor's creation when cancer cell proliferation is beginning, fibroblasts rush to the scene to aid in healing. However, Dr. Erez's research shows that these ordinarily helpful cells can actually be turned against the body, enhancing tumor growth by stimulating inflammation.

Her research was done in animal models using fresh mouse skin cancer as well as human tumors extracted in the operating room. It was originally carried out at the University of California, San Francisco in the lab of Prof. Douglas Hanahan. Published in Cancer Cell, her most recent findings demonstrate that a growing tumor can co-opt fibroblasts, turning them into cancer-associated fibroblasts (CAFs) making them do the dirty work of supporting tumors.

Cancer and inflammation a two-way street

In recent years, scientists have begun to understand the link between inflammation and cancer. Their findings suggested why long-term aspirin therapy which reduces inflammation can help prevent or slow cancer growth.

Inflammation causes cancer, and researchers are now finding that the reverse is also true: cancer can also cause inflammation by attracting immune cells to sites of growing tumors. Inflammatory cells are implicated in all solid tumors, including liver cancer, which may start with chronic liver inflammation due to hepatitis, and intestinal or colon cancer, which can be triggered by chronic inflammation of the bowels from an ulcer, colitis or Crohn's disease.

"Cancer cells recruit CAFs at very early stages," Dr. Erez says. "Under normal circumstances fibroblasts are very good for health and healing, but we've shown for the first time how they can be coerced into supporting inflammation that enhances the growth of tumors."

CAFs stimulate inflammation and angiogenesis the creation of new blood cells which in turn enable cancer cell proliferation. Without the recruitment of new blood vessels, cancer couldn't grow bigger than a millimeter. Tumor growth requires the assistance of other tissues in our body, and Dr. Erez's research implicating fibroblasts breaks new ground in science.

New avenues for drug research

CAFs appear to be able to recruit immune cells from the body that can enhance tumor growth, Dr. Erez explains. In addition, normal skin fibroblasts can be "educated" by cancer cells to express pro-inflammatory genes.

Armed with this information, Dr. Erez plans to study the molecular pathways that link tumor cells to their environments around the tumors, hoping to develop drug targets to disrupt any cellular processes that support tumor growth. Her research opens a new frontier, suggesting how inflammation in the body can be managed to reduce the growth and spread of cancer.

"My goal is to understand everything about the local environment where a tumor grows what feeds it, what cells play a role, and how they work together to improve existing therapeutics, or to create a new cancer drug," she says.


'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Related biology news :

1. H. Pylori bacteria may help prevent some esophageal cancers
2. On the trail of a targeted therapy for blood cancers
3. Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening
4. Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target
5. NC State researchers find soy may aid in treating canine cancers
6. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
7. Possible drug target found for one of the most aggressive breast cancers
8. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
9. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
10. Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
11. Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Infiltrating cancer's recruitment center
(Date:4/28/2016)... , April 28, 2016 First quarter 2016: ... up 966% compared with the first quarter of 2015 ... SEK 589.1 M (loss: 18.8) and the operating margin was 40% ... 0.32) Cash flow from operations was SEK 249.9 M ... revenue guidance is unchanged, SEK 7,000-8,500 M. The operating ...
(Date:4/19/2016)... 20, 2016 The new GEZE ... compact web-based "all-in-one" system solution for all door components. ... or the door interface with integration authorization management system, ... systems. The minimal dimensions of the access control and ... building installations offer considerable freedom of design with regard ...
(Date:4/14/2016)... TEL AVIV, Israel , April 14, 2016 /PRNewswire/ ... in Behavioral Authentication and Malware Detection, today announced the ... has already assumed the new role. Goldwerger,s ... for BioCatch, on the heels of the deployment of ... In addition, BioCatch,s behavioral biometric technology, which discerns unique ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... DIEGO , June 27, 2016  Sequenom, Inc. ... committed to enabling healthier lives through the development of ... Court of the United States ... courts that the claims of Sequenom,s U.S. Patent No. ... patent eligibility criteria established by the Supreme Court,s Mayo ...
(Date:6/27/2016)... Diego, CA (PRWEB) , ... June 27, 2016 , ... ... solutions for clinical trials, announced today the Clinical Reach Virtual Patient Encounter ... their care circle with the physician and clinical trial team. , Using the CONSULT ...
(Date:6/27/2016)... Chapel Hill, N.C. (PRWEB) , ... June 27, ... ... of U.S. commercial operations for Amgen, will join the faculty of the ... will serve as adjunct professor of strategy and entrepreneurship at UNC Kenan-Flagler, with ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks ... to industrial engineering, was today awarded as one ... selection of the world,s most innovative companies. Ginkgo ... scale for the real world in the nutrition, ... engineers work directly with customers including Fortune 500 ...
Breaking Biology Technology: