Navigation Links
Infiltrating cancer's recruitment center
Date:1/26/2011

Tel Aviv The most common connective tissue cell in animals is the fibroblast, which plays an important role in healing wounds. But Dr. Neta Erez of Tel Aviv University's Sackler Faculty of Medicine has now demonstrated that fibroblasts can also do a body great harm, helping to "recruit" immune cells for tumor growth.

At the onset of a tumor's creation when cancer cell proliferation is beginning, fibroblasts rush to the scene to aid in healing. However, Dr. Erez's research shows that these ordinarily helpful cells can actually be turned against the body, enhancing tumor growth by stimulating inflammation.

Her research was done in animal models using fresh mouse skin cancer as well as human tumors extracted in the operating room. It was originally carried out at the University of California, San Francisco in the lab of Prof. Douglas Hanahan. Published in Cancer Cell, her most recent findings demonstrate that a growing tumor can co-opt fibroblasts, turning them into cancer-associated fibroblasts (CAFs) making them do the dirty work of supporting tumors.

Cancer and inflammation a two-way street

In recent years, scientists have begun to understand the link between inflammation and cancer. Their findings suggested why long-term aspirin therapy which reduces inflammation can help prevent or slow cancer growth.

Inflammation causes cancer, and researchers are now finding that the reverse is also true: cancer can also cause inflammation by attracting immune cells to sites of growing tumors. Inflammatory cells are implicated in all solid tumors, including liver cancer, which may start with chronic liver inflammation due to hepatitis, and intestinal or colon cancer, which can be triggered by chronic inflammation of the bowels from an ulcer, colitis or Crohn's disease.

"Cancer cells recruit CAFs at very early stages," Dr. Erez says. "Under normal circumstances fibroblasts are very good for health
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. H. Pylori bacteria may help prevent some esophageal cancers
2. On the trail of a targeted therapy for blood cancers
3. Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening
4. Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target
5. NC State researchers find soy may aid in treating canine cancers
6. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
7. Possible drug target found for one of the most aggressive breast cancers
8. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
9. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
10. Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
11. Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Infiltrating cancer's recruitment center
(Date:4/27/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... first week of May, 2015 and will be fulfilling ... Gino Pereira , Chief Executive Officer ... as Wocket® enters the consumer market. We would like ...
(Date:4/21/2015)... 21, 2015 High crime ... are boosting access control systems market in ... a recently published report by TechSci Research " Saudi ... access control systems market in Saudi Arabia ... 2020.The access control systems market in the Kingdom is ...
(Date:4/20/2015)... 2015 The announcement comes as ... Records Management (GRM), Ireland,s foremost records ... Having built up an impressive track record of clients within ... within the records management sector in Dubai ... GCC staffbase and employ a further eight staff members at ...
Breaking Biology News(10 mins):Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 2Wocket, the Smartest Wallet You Will Ever Own, Announces Shipment to Pre-order Customers 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 2Glenbeigh Records Management Wins Contract With Dubai Islamic Bank 3
... Americans, protects some people with heart failure, enabling them ... a research team led by investigators at the University ... Washington University School of Medicine in St. Louis. The ... beta-blockers, a class of drugs used to treat chronic ...
... computer simulation has revealed a self-healing behavior in ... of radiation-resistant materials for nuclear power plants and ... of Energy,s Pacific Northwest National Laboratory found that ... damage in the engineered ceramic yttria-stabilized zirconia. ...
... shows clearly that powerful starquakes ripple around the Sun in ... surface. The observations give solar physicists new insight into a ... studying other stars. The outermost quarter of the Suns ... in this region causes ripples that criss-cross the solar surface, ...
Cached Biology News:Genetic variant mimics effect of heart failure medications 2Genetic variant mimics effect of heart failure medications 3Genetic variant mimics effect of heart failure medications 4Ceramic, heal thyself 2Solar flares set the Sun quaking 2
(Date:5/4/2015)... TEL AVIV, Israel , May 4, 2015 /PRNewswire/ ... has filed its annual report on Form 20-F for ... U.S. Securities and Exchange Commission ("SEC"). The annual report ... for the development of antibodies in the area of ... antibodies with superior qualities of high specificity and binding ...
(Date:5/4/2015)... 2015 /PRNewswire/ - The Fight Against Cancer Innovation ... announce the formation of Turnstone Biologics Inc. (Turnstone), ... cancer that harness the patient,s own immune system. ... between the Children,s Hospital of Eastern ... the Ontario Institute for Cancer Research (OICR), the ...
(Date:5/4/2015)... Achieved primarily through a proprietary paraffin ... 10 to 100x better detail than the industry standard. ... existing light microscopy methods, it needed another medium to ... the frame of reference because it represents the highest ... from the earliest discovery days of Ultralight Histology was ...
(Date:5/4/2015)... , May 4, 2015 ... thousands of med students prepare for the United States ... world-leading provider of scientific, technical and medical information products ... free MOOC (Massive Open Online Course) designed to help ... Examination (USMLE) Step 1, the first and most daunting ...
Breaking Biology Technology:Tikcro Technologies Files Annual Report on Form 20-F for the Year Ended December 31, 2014 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 2Turnstone Biologics Inc. to accelerate clinical and commercial translation of cancer immunotherapies 3Elsevier's Free MOOC Prepares Med Students for Licensing Exam 2Elsevier's Free MOOC Prepares Med Students for Licensing Exam 3
... to a multiplex near you, but movies showing the ... have blockbuster potential. A team of scientists with the ... of California (UC) Berkeley has developed a technique for ... that chemical reactions in the liquids can be imaged ...
... development of new applications based on nanoimprinting techniques (NIL) is ... challenges to be overcome in order to reach the market? ... its uptake from the industry? What are the tools needed ... exactly with this topic, i.e. Nanopatterning, Production and Applications based ...
... 20, 2012     On May 21-23, 2012, ... created to support, mentor, and develop minority-, woman-, ... host its fifth annual networking conference and EXPO ... health advocate, will address the conference held at ...
Cached Biology Technology:First atomic-scale real-time movies of platinum nanocrystal growth in liquids 2First atomic-scale real-time movies of platinum nanocrystal growth in liquids 3First atomic-scale real-time movies of platinum nanocrystal growth in liquids 4First atomic-scale real-time movies of platinum nanocrystal growth in liquids 5Low-cost optical components through nanoimprinting lithography 2Low-cost optical components through nanoimprinting lithography 3Music Legend And Health Advocate Bret Michaels To Address Diversity Alliance For Science 2012 National Conference And EXPO 2Music Legend And Health Advocate Bret Michaels To Address Diversity Alliance For Science 2012 National Conference And EXPO 3
... Modular system for large format and ... six lab-cast or precast gels (26 ... or 24-cm Immobiline DryStrip gels.Simple-to-use 1.0-mm ... design simplifies loading and unloading.Built-in ceramic ...
Edited by P.J. Delves (1997) An up-to-date review of antibody-raising technologies, this volume provides researchers with immediate access to the protocols they require every day....
Request Info...
MOUSE ANTI HUMAN FACTOR I...
Biology Products: