Navigation Links
Infiltrating cancer's recruitment center

Tel Aviv The most common connective tissue cell in animals is the fibroblast, which plays an important role in healing wounds. But Dr. Neta Erez of Tel Aviv University's Sackler Faculty of Medicine has now demonstrated that fibroblasts can also do a body great harm, helping to "recruit" immune cells for tumor growth.

At the onset of a tumor's creation when cancer cell proliferation is beginning, fibroblasts rush to the scene to aid in healing. However, Dr. Erez's research shows that these ordinarily helpful cells can actually be turned against the body, enhancing tumor growth by stimulating inflammation.

Her research was done in animal models using fresh mouse skin cancer as well as human tumors extracted in the operating room. It was originally carried out at the University of California, San Francisco in the lab of Prof. Douglas Hanahan. Published in Cancer Cell, her most recent findings demonstrate that a growing tumor can co-opt fibroblasts, turning them into cancer-associated fibroblasts (CAFs) making them do the dirty work of supporting tumors.

Cancer and inflammation a two-way street

In recent years, scientists have begun to understand the link between inflammation and cancer. Their findings suggested why long-term aspirin therapy which reduces inflammation can help prevent or slow cancer growth.

Inflammation causes cancer, and researchers are now finding that the reverse is also true: cancer can also cause inflammation by attracting immune cells to sites of growing tumors. Inflammatory cells are implicated in all solid tumors, including liver cancer, which may start with chronic liver inflammation due to hepatitis, and intestinal or colon cancer, which can be triggered by chronic inflammation of the bowels from an ulcer, colitis or Crohn's disease.

"Cancer cells recruit CAFs at very early stages," Dr. Erez says. "Under normal circumstances fibroblasts are very good for health and healing, but we've shown for the first time how they can be coerced into supporting inflammation that enhances the growth of tumors."

CAFs stimulate inflammation and angiogenesis the creation of new blood cells which in turn enable cancer cell proliferation. Without the recruitment of new blood vessels, cancer couldn't grow bigger than a millimeter. Tumor growth requires the assistance of other tissues in our body, and Dr. Erez's research implicating fibroblasts breaks new ground in science.

New avenues for drug research

CAFs appear to be able to recruit immune cells from the body that can enhance tumor growth, Dr. Erez explains. In addition, normal skin fibroblasts can be "educated" by cancer cells to express pro-inflammatory genes.

Armed with this information, Dr. Erez plans to study the molecular pathways that link tumor cells to their environments around the tumors, hoping to develop drug targets to disrupt any cellular processes that support tumor growth. Her research opens a new frontier, suggesting how inflammation in the body can be managed to reduce the growth and spread of cancer.

"My goal is to understand everything about the local environment where a tumor grows what feeds it, what cells play a role, and how they work together to improve existing therapeutics, or to create a new cancer drug," she says.


Contact: George Hunka
American Friends of Tel Aviv University

Related biology news :

1. H. Pylori bacteria may help prevent some esophageal cancers
2. On the trail of a targeted therapy for blood cancers
3. Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening
4. Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target
5. NC State researchers find soy may aid in treating canine cancers
6. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
7. Possible drug target found for one of the most aggressive breast cancers
8. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
9. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
10. Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
11. Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
Post Your Comments:
Related Image:
Infiltrating cancer's recruitment center
(Date:6/22/2016)... 22, 2016  The American College of Medical Genetics and ... Magazine as one of the fastest-growing trade shows during ... the Bellagio in Las Vegas . ... of growth in each of the following categories: net square ... number of attendees. The 2015 ACMG Annual Meeting was ranked ...
(Date:6/16/2016)... , June 16, 2016 ... is expected to reach USD 1.83 billion by ... View Research, Inc. Technological proliferation and increasing demand ... are expected to drive the market growth. ... The development of advanced multimodal techniques ...
(Date:6/3/2016)... 2016 Das DOTM ... Nepal hat ein 44 Millionen ... Kennzeichen, einschließlich Personalisierung, Registrierung und IT-Infrastruktur, an ... und Implementierung von Identitätsmanagementlösungen. Zahlreiche renommierte internationale ... teilgenommen, aber Decatur wurde als konformste und ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... -- Houston Methodist Willowbrook Hospital has signed a ... serve as their official health care provider. As ... provide sponsorship support, athletic training services, and most ... athletes and families. "We are excited ... to bring Houston Methodist quality services and programs ...
(Date:6/23/2016)... ... 2016 , ... Supplyframe, the Industry Network for electronics hardware ... . Located in Pasadena, Calif., the Design Lab’s mission is to bring together ... built and brought to market. , The Design Lab is Supplyframe’s physical representation ...
(Date:6/23/2016)... LONDON , June 23, 2016 ... & Hematology Review, 2016;12(1):22-8 ... Review , the peer-reviewed journal from touchONCOLOGY, ... the escalating cost of cancer care is placing ... a result of expensive biologic therapies. With the ...
(Date:6/23/2016)...  Amgen (NASDAQ: AMGN ) today announced ... life sciences incubator to accelerate the development of new ... at QB3@953 was created to help high-potential life science ... early stage organizations - access to laboratory infrastructure. ... two "Amgen Golden Ticket" awards, providing each winner with ...
Breaking Biology Technology: