Navigation Links
Infiltrating cancer's recruitment center
Date:1/26/2011

Tel Aviv The most common connective tissue cell in animals is the fibroblast, which plays an important role in healing wounds. But Dr. Neta Erez of Tel Aviv University's Sackler Faculty of Medicine has now demonstrated that fibroblasts can also do a body great harm, helping to "recruit" immune cells for tumor growth.

At the onset of a tumor's creation when cancer cell proliferation is beginning, fibroblasts rush to the scene to aid in healing. However, Dr. Erez's research shows that these ordinarily helpful cells can actually be turned against the body, enhancing tumor growth by stimulating inflammation.

Her research was done in animal models using fresh mouse skin cancer as well as human tumors extracted in the operating room. It was originally carried out at the University of California, San Francisco in the lab of Prof. Douglas Hanahan. Published in Cancer Cell, her most recent findings demonstrate that a growing tumor can co-opt fibroblasts, turning them into cancer-associated fibroblasts (CAFs) making them do the dirty work of supporting tumors.

Cancer and inflammation a two-way street

In recent years, scientists have begun to understand the link between inflammation and cancer. Their findings suggested why long-term aspirin therapy which reduces inflammation can help prevent or slow cancer growth.

Inflammation causes cancer, and researchers are now finding that the reverse is also true: cancer can also cause inflammation by attracting immune cells to sites of growing tumors. Inflammatory cells are implicated in all solid tumors, including liver cancer, which may start with chronic liver inflammation due to hepatitis, and intestinal or colon cancer, which can be triggered by chronic inflammation of the bowels from an ulcer, colitis or Crohn's disease.

"Cancer cells recruit CAFs at very early stages," Dr. Erez says. "Under normal circumstances fibroblasts are very good for health
'/>"/>

Contact: George Hunka
ghunka@aftau.org
212-742-9070
American Friends of Tel Aviv University
Source:Eurekalert  

Page: 1 2

Related biology news :

1. H. Pylori bacteria may help prevent some esophageal cancers
2. On the trail of a targeted therapy for blood cancers
3. Oral rinses used for tracking HPV-positive head and neck cancers holds promise for cancer screening
4. Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target
5. NC State researchers find soy may aid in treating canine cancers
6. Newly discovered epidermal growth factor receptor active in human pancreatic cancers
7. Possible drug target found for one of the most aggressive breast cancers
8. Fox Chase researchers uncover one force behind the MYC oncogene in many cancers
9. New blood tests promise simple, cost-effective diagnosis of gastrointestinal cancers
10. Loss of tumor supressor gene essential to transforming benign nerve tumors into cancers
11. Discovery at JGH opens door to new treatments for prostate, brain and skin cancers
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Infiltrating cancer's recruitment center
(Date:11/21/2014)... 2014  Earlier this year Donald Spector , ... one of the most prolific inventors in the world, ... from Smartphones to third party agencies. Spector envisioned this ... of the earliest known patents in this area. Now ... military, child care, elder care and hospital applications. This ...
(Date:11/21/2014)... Nov. 20, 2014 C-Labs LLC, a leading ... of Things (IoT), today announced the appointment of ... officer. Previously a strategic advisor to the firm, Mr. ... Mr. Traynor is based out of the C-Labs office ... to Chris Muench , Chief Executive Officer. ...
(Date:11/18/2014)...  The Secure Identity & Biometrics Association (SIBA) ... the formation of The Airport Entry and Exit ... and Biometric Entry and Exit Solutions Framework for ... from BORDERPOL, the international non-profit organization that works ... regarding border security, traveler and migration systems. ...
Breaking Biology News(10 mins):Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 2Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 3Patented Biosensor Wearable Technology Provides a More Civilized Method of Quarantine 4C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 2Identity Management, Document Authentication and Biometric Companies Form "The Airport Entry and Exit Working Group", Releasing the Framework to Help Guide the Department of Homeland Security and Congress Towards Solutions 3
... CHESTERFIELD, Mo. , April 22, 2013 The ... panel of experts from multiple disciplines, including farmers, media, ... questions surrounding GMOs. This discussion was moderated by CNBC ... The Food Dialogues℠: Chicago , which ...
... checked were for native Australian millipede species and were published ... and the Atlas of Living Australia , ALA. GBIF ... but disclaim any responsibility for errors in museum databases, instead ... fit for purpose. The auditing was done voluntarily by ...
... April 2013. Researchers have known for some years that the ... Arctic when the waters in its traditional habitat become too ... are now moving up as far as Spitsbergen into the ... two and a half years, biologists from the Alfred Wegener ...
Cached Biology News:CNBC Senior Analyst Ron Insana Moderates Discussion On Biotech Seeds At The Food Dialogues(SM): Chicago 2CNBC Senior Analyst Ron Insana Moderates Discussion On Biotech Seeds At The Food Dialogues(SM): Chicago 3Online biodiversity databases audited: 'Improvement needed' 2Atlantic cod in for even more stress? 2Atlantic cod in for even more stress? 3
(Date:11/21/2014)... (PRWEB) November 19, 2014 The science ... lives was shared with more than 200 primary students ... students from the University of Otago Physics Department and ... The Otago students, members of the university’s OSA/SPIE Student ... in early September, giving children from small, rural schools ...
(Date:11/21/2014)... The November 2014 issue of BioTechniques ( ... journal featuring the following articles:, , ... in the retina , DNA from fingermarks ... chromogenic substrates in zebrafish , Re-use of ... , Nuclear LC3-positive puncta in stressed cells ...
(Date:11/21/2014)... , Nov. 20, 2014 Polaris ... been dosed in its Phase 1 trial of ... for the treatment of malignant pleural mesothelioma (MPM) ... is conducting clinical trials on ADI-PEG 20, both ... for the treatment of several other indications, including ...
(Date:11/18/2014)... Sarasota, FL (PRWEB) November 17, 2014 ... novel point-of-care diagnostic tests – today announces its ... Control and Prevention’s (CDC) Get Smart About Antibiotics ... Antibiotics Week is a national campaign designed to ... local health departments, and non-profit and for-profit partners ...
Breaking Biology Technology:Optics and photonics outreach programs share science, spark fascination with light 2Optics and photonics outreach programs share science, spark fascination with light 3BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 2BioTechniques: The International Journal of Life Science Methods Announces the Publication of the November 2014 Issue—Available in Print and Online 3Polaris Group Announces Treatment of First Patient in Phase 1 Study of ADI-PEG 20 plus Pemetrexed and Cisplatin in Malignant Pleural Mesothelioma And Non-Squamous Non-Small Cell Lung Carcinoma 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 2RPS Again Partners with the CDC in Support of the 2014 Get Smart About Antibiotics Week 3
... Pa., May 7 Encorium Group, Inc. ... multinational contract research organization (CRO) that provides design, ... patient registries to many of the world,s leading ... M.D., Ph.D. has been appointed Head Consultant of ...
... EAST BRUNSWICK, N.J., May 7 Savient Pharmaceuticals, Inc. ... biologics license application (BLA) for KRYSTEXXA (TM) (pegloticase), ... patients, will be reviewed by the Arthritis Advisory Committee ... on June 16, 2009. In December, the FDA ...
... May 7 Sigma-Aldrich Corporation (Nasdaq: SIAL ) ... Lynch 2009 Healthcare Conference on Wednesday, May 13th at 2:00 ... parties may listen via live audio broadcast over the Internet ... can click the "Webcast" icon to access this file. ...
Cached Biology Technology:Professor Hanna Nohynek Joins Encorium as Head Consultant of its Clinical Vaccine Research Team 2Professor Hanna Nohynek Joins Encorium as Head Consultant of its Clinical Vaccine Research Team 3Professor Hanna Nohynek Joins Encorium as Head Consultant of its Clinical Vaccine Research Team 4Savient Announces New Date for FDA Arthritis Advisory Panel Review of KRYSTEXXA(TM) for Treatment Failure Gout 2Savient Announces New Date for FDA Arthritis Advisory Panel Review of KRYSTEXXA(TM) for Treatment Failure Gout 3Savient Announces New Date for FDA Arthritis Advisory Panel Review of KRYSTEXXA(TM) for Treatment Failure Gout 4Sigma-Aldrich to Present at the Bank of America and Merrill Lynch 2009 Healthcare Conference on Wednesday, May 13, 2009 2
... Acridinium NHS ester can be ... nucleic acids. The covalently bound ... chemiluminescence in the presence of ... proteins can be used as ...
... is making flow cytometry accessible to anyone in ... the latest addition to Guavas on-demand microcapillary flow ... easy to use, surprisingly affordable, very compact, and ... detection. The Guava EasyCyte Mini has all of ...
... MiniOpticon 2-color real-time PCR detection system holds 48 x ... of 48 LEDs independently excites fluorescence (470-500 nm) for ... emitted light (523-543 nm and 540-700 nm). This item ... Mini thermal cycler. System dimensions are 18 x 32 ...
... Cytomics FC 500 Series is ... with the most advanced technologies ... delivers flexible testing, powerful software ... that help researchers optimize their ...
Biology Products: