Navigation Links
Infection biology: The elusive third factor
Date:6/22/2012

Researchers from Ludwig-Maximilians-Universitt (LMU) in Munich have identified an enzyme that is involved in a modification pathway that is essential for bacterial pathogenicity. Because it shows no similarity to other known proteins, it may be an ideal target for development of novel antimicrobial drugs.

Studies on a number of pathogenic bacteria have shown that these strains become pathogenic only when an enzyme called elongation factor P (EF-P) is chemically modified on a conserved lysine residue. EF-P is a universally conserved translation factor, which is involved in protein synthesis. Two enzymes are known to be involved in modifying the conserved lysine of EF-P, however these enzymes cannot fully account for the pattern of modification seen on EF-P in living cells.

The mystery molecule

Thus, at least one other protein must be involved in the modification process however to date it has proved to be particularly elusive. Now a research team led by LMU biochemist Daniel Wilson, who is also affiliated with the Center for Integrated Protein Science Munich (CIPSM), a Cluster of Excellence at LMU, has succeeded in identifying the mystery protein as the enzyme YfcM and showing that it displays hydroxylase activity. Strikingly, YfcM shows no sequence similarity to any other known protein and therefore may have a unique structure.

This is not the only reason why discovery of YfcM will arouse great interest. "YfcM may turn out to be an ideal target for the development of new - and urgently needed antibiotics, however more insight will be needed to ascertain the role of the YfcM mediated hydroxylation of EF-P," says Wilson.


'/>"/>
Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1

Related biology news :

1. Childhood virus infection linked to prolonged seizures with fever
2. How alert hospital employees improved hospitals MSRA infection rate
3. New data suggests HIV superinfection rate comparable to initial HIV infection
4. Vitamin D supplements may protect against viral infections during the winter
5. Salmonella infection, but not as we know it
6. Bartonella infection associated with rheumatoid illnesses in humans
7. Women & Infants participating in study of treatment of common viral infection in pregnancy
8. To drive infections, a hijacking virus mimics a cells signaling system
9. BPA could affect reproductive capabilities, cause infection of the uterus
10. Queens scientists seek vaccine for Pseudomonas infection
11. New screening technique yields elusive compounds to block immune-regulating enzyme
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/5/2018)... ... 04, 2018 , ... Biolytic Lab Performance Inc. is proud ... on Biolytic’s Molecule Synthesis Platform. , Now restructured with all the same ... fastest in oligonucleotide synthesis, the 192c incorporates a multitude of enhancements to new ...
(Date:11/27/2018)... ... November 27, 2018 , ... ... Pepe, P.E., as Chief Operating Officer (COO). Dave joins the executive leadership ... the company’s internal functions. Dave will also serve in a key strategic ...
(Date:11/27/2018)... ... November 27, 2018 , ... LabArchives ... worked together to integrate the LabArchives Classroom Edition with Current Protocols Essential Laboratory ... be available beginning January of 2019. , The integration of LabArchives ...
Breaking Biology News(10 mins):
(Date:11/13/2018)... ... 2018 , ... Aditya Humad, Managing Partner of KICVentures ... it is still trending upward with growing valuations based on a largely under-served ... pricing pressure and increased competition as reasons often cited by institutional investors to ...
(Date:11/9/2018)... FRANCISCO (PRWEB) , ... November 08, 2018 , ... ... of Dr. Pablo Valenzuela, PhD, co-Founder, Chief Executive Officer and President of Andes ... doctors from around the world, Dr. Valenzuela brings to uBiome expertise on the ...
(Date:11/7/2018)... (PRWEB) , ... November 07, 2018 , ... Diversified ... for algae at AzCATI, the Arizona Center for Algae Technology and Innovation at ASU. ... process development and trials for those involved with algal and predator control applications. , ...
(Date:11/5/2018)... , ... November 05, 2018 , ... ... live educational support for healthcare professionals through its website, http://www.glycomark.com , as ... a live chat and video option via the website in November from 9 ...
Breaking Biology Technology: