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Infection biology: How Legionella subverts to survive
Date:7/18/2013

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The biochemical processes that enable the parasites to outwit their temporary hosts are highly complex. Thus, L. pneumophila secretes around 300 proteins into the infected cell, which is forced to redirect its resources for the bacterium's benefit.

Hilbi and his colleagues have now characterized one of these proteins and describe its mode of action for the first time. This factor, called RidL, disrupts an intracellular transport system that is necessary for the elimination of ingested bacteria. RidL binds to the so-called retromer complex, which is needed for the continued recycling of receptors, which deliver degradative enzymes to phagosomes containing bacteria destined for digestion. "We demonstrate that Legionella blocks the retromer-dependent transport route, thus promoting its own survival in the cell," Hilbi explains. This function is unique. "Proteins that act in this way are otherwise unknown in the bacterial world, and are not found in higher organisms either," he adds.


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Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Page: 1 2

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