Bacteria of the genus Legionella have evolved a sophisticated system to replicate in the phagocytic cells of their hosts. Researchers at Ludwig-Maximilians-Universitaet (LMU) in Munich have now identified a novel component of this system.
In humans, Legionella is responsible for the so-called Legionnaires' disease, a form of bacterial pneumonia that is often lethal. The bacteria can also cause Pontiac fever, a flu-like condition characterized by coughing and vomiting. Most Legionella-associated illnesses in humans are caused by Legionella pneumophila.
These microorganisms are found in soil, lakes and rivers, and can enter our water supply via the groundwater. The greatest risk of human infection arises when the bacteria colonize air-conditioning ducts or piping used to transport warm water. Persons can be infected when they inhale contaminated aerosols in the shower, for instance.
The research group led by Hubert Hilbi, Professor of Medical Microbiology at LMU, studies how these intracellular parasites survive and replicate in phagocytic cells of their eukaryotic hosts or in the environment. For instance, the pathogen can grow and proliferate in the amoeba Dictyostelium, which normally preys on soil bacteria, engulfing and digesting them. But Legionella turns the tables, resists degradation and continues to grow in the amoeba until it is so full of bacteria that it bursts.
Legionella sabotages the immune system
When L. pneumophila cells infect the human lung, essentially the same thing happens. The bacteria are taken up by white blood cells called macrophages, which normally clear bacterial pathogens from the circulation. But instead of being consumed, the bacteria replicate in the macrophages and ultimately destroy them. Robbed of its first line of defense, the immune system has difficulty coping with the infection, and a life-threatening pneumonia ma
|Contact: Luise Dirscherl|