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Induction of mild inflammation leads to cognitive deficits related to schizophrenia
Date:2/6/2013

ased gamma power on electroencephalograms, activation of astrocytes, and a thinner cortex.

The researchers also succeeded in rescuing the working memory deficit, impaired nest-building behavior, and some features of iDG in the brain of this schizophrenia model mouse by chronically administering anti-inflammatory drugs. This finding highlights the possibility that genetically-induced changes in the immune system may be a predisposing factor in schizophrenia, providing the groundwork for further studies to elucidate the pathogenesis and pathophysiology of schizophrenia using this model.


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Contact: Prof. Tsuyoshi Miyakawa
miyakawa@fujita-hu.ac.jp
81-562-939-375
National Institute for Physiological Sciences
Source:Eurekalert

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