Navigation Links
Induction of mild inflammation leads to cognitive deficits related to schizophrenia
Date:2/6/2013

Researchers at the Institute for Comprehensive Medical Science, Fujita Health University and the National Institute for Physiological Sciences, Japan, along with colleagues from 9 other institutions, have identified an exceptional mouse model of schizophrenia. After screening over 160 mutant mouse strains with a systematic battery of behavioral tests, they identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia. Shn-2 is an NF-B site-binding protein that binds enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which harbor common variant single nucleotide polymorphisms associated with schizophrenia. The Shn-2 KO mice display behavioral abnormalities that resemble the symptoms of human schizophrenia, including working memory deficits, impaired nest building behavior (a measure of self-neglect), decreased social behaviors, and anhedonia (loss of the ability to experience pleasure).

Drs. Tsuyoshi Miyakawa, Keizo Takao, and their colleagues found that Shn-2 deficiency results in mild chronic brain inflammation, which leads to a unique alteration of a specific region in the brain, the dentate gyrus. The "immature Dentate Gyrus (iDG)", as it is referred to by the researchers, is presumed to produce schizophrenia-related phenotypes, such as working memory deficits and impaired nest-building behavior, as reported online February 6th in Neuropsychopharmacology.

The transcriptome patterns in the prefrontal cortex of the Shn-2 KO mice and post-mortem schizophrenia patients are surprisingly similar, with 100 commonly altered genes. Interestingly, 11 of the top 20 ranked genes with altered expression levels are involved in inflammatory or immune function. The brains of the mutant mice also exhibit numerous schizophrenia-related phenotypes, including decreased parvalbumin and GAD67 levels, increased theta and decreased gamma power on electroencephalograms, activation of astrocytes, and a thinner cortex.

The researchers also succeeded in rescuing the working memory deficit, impaired nest-building behavior, and some features of iDG in the brain of this schizophrenia model mouse by chronically administering anti-inflammatory drugs. This finding highlights the possibility that genetically-induced changes in the immune system may be a predisposing factor in schizophrenia, providing the groundwork for further studies to elucidate the pathogenesis and pathophysiology of schizophrenia using this model.


'/>"/>

Contact: Prof. Tsuyoshi Miyakawa
miyakawa@fujita-hu.ac.jp
81-562-939-375
National Institute for Physiological Sciences
Source:Eurekalert

Related biology news :

1. Monitoring and robust induction of nephrogenic intermediate mesoderm from human iPSCs
2. FASEB SRC announces conference: Gastrointestinal Tract XV: Epithelia, Microbes, Inflammation & Cancer
3. Team finds a new way to inhibit blood clotting and inflammation
4. Inflammation and cognition in schizophrenia
5. A solution to reducing inflammation
6. Cell receptor has proclivity for T helper 9 cells, airway inflammation
7. Chronic inflammation in the brain leads the way to Alzheimers disease
8. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
9. Omega-3 lowers inflammation in overweight older adults
10. Intestinal bacteria produce neurotransmitter, could play role in inflammation
11. Modest alcohol intake associated with less inflammation in patients with common liver disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... April 24, 2017 Janice Kephart ... with  Identity Strategy Partners, LLP (IdSP) , today ... without President Trump,s March 6, 2017 Executive ... , refugee vetting can be instilled with greater confidence, ... now, all refugee applications are suspended by until ...
(Date:4/13/2017)... According to a new market research report "Consumer ... Administration, and Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - ... to grow from USD 14.30 Billion in 2017 to USD 31.75 Billion ... ... MarketsandMarkets Logo ...
(Date:4/6/2017)... Forecasts by Product Type (EAC), ... End-Use (Transportation & Logistics, Government & Public Sector, Utilities ... Generation Facility, Nuclear Power), Industrial, Retail, Business Organisation (BFSI), ... you looking for a definitive report on the $27.9bn ... ...
Breaking Biology News(10 mins):
(Date:10/12/2017)... San Diego, CA (PRWEB) , ... ... ... BioInformatics (https://www.onramp.bio/ ) has launched Rosalind™, the first-ever genomics analysis platform ... eliminating all bioinformatics complexity. Named in honor of pioneering researcher Rosalind Franklin, ...
(Date:10/11/2017)... ... October 11, 2017 , ... ... in its endogenous context, enabling overexpression experiments and avoiding the use of exogenous ... RNA guides is transformative for performing systematic gain-of-function studies. , This complement ...
(Date:10/11/2017)... ... 11, 2017 , ... ComplianceOnline’s Medical Device Summit is back for its 4th ... in San Francisco, CA. The Summit brings together current and former FDA office bearers, ... and government officials from around the world to address key issues in device compliance, ...
(Date:10/11/2017)... a leading provider of patient support solutions, has announced the ... which will launch this week. The VMS CNEs will address ... enhance the patient care experience by delivering peer-to-peer education programs ... to help women who have been diagnosed and are being ... ...
Breaking Biology Technology: