Navigation Links
Induction of mild inflammation leads to cognitive deficits related to schizophrenia

Researchers at the Institute for Comprehensive Medical Science, Fujita Health University and the National Institute for Physiological Sciences, Japan, along with colleagues from 9 other institutions, have identified an exceptional mouse model of schizophrenia. After screening over 160 mutant mouse strains with a systematic battery of behavioral tests, they identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia. Shn-2 is an NF-B site-binding protein that binds enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which harbor common variant single nucleotide polymorphisms associated with schizophrenia. The Shn-2 KO mice display behavioral abnormalities that resemble the symptoms of human schizophrenia, including working memory deficits, impaired nest building behavior (a measure of self-neglect), decreased social behaviors, and anhedonia (loss of the ability to experience pleasure).

Drs. Tsuyoshi Miyakawa, Keizo Takao, and their colleagues found that Shn-2 deficiency results in mild chronic brain inflammation, which leads to a unique alteration of a specific region in the brain, the dentate gyrus. The "immature Dentate Gyrus (iDG)", as it is referred to by the researchers, is presumed to produce schizophrenia-related phenotypes, such as working memory deficits and impaired nest-building behavior, as reported online February 6th in Neuropsychopharmacology.

The transcriptome patterns in the prefrontal cortex of the Shn-2 KO mice and post-mortem schizophrenia patients are surprisingly similar, with 100 commonly altered genes. Interestingly, 11 of the top 20 ranked genes with altered expression levels are involved in inflammatory or immune function. The brains of the mutant mice also exhibit numerous schizophrenia-related phenotypes, including decreased parvalbumin and GAD67 levels, increased theta and decreased gamma power on electroencephalograms, activation of astrocytes, and a thinner cortex.

The researchers also succeeded in rescuing the working memory deficit, impaired nest-building behavior, and some features of iDG in the brain of this schizophrenia model mouse by chronically administering anti-inflammatory drugs. This finding highlights the possibility that genetically-induced changes in the immune system may be a predisposing factor in schizophrenia, providing the groundwork for further studies to elucidate the pathogenesis and pathophysiology of schizophrenia using this model.


Contact: Prof. Tsuyoshi Miyakawa
National Institute for Physiological Sciences

Related biology news :

1. Monitoring and robust induction of nephrogenic intermediate mesoderm from human iPSCs
2. FASEB SRC announces conference: Gastrointestinal Tract XV: Epithelia, Microbes, Inflammation & Cancer
3. Team finds a new way to inhibit blood clotting and inflammation
4. Inflammation and cognition in schizophrenia
5. A solution to reducing inflammation
6. Cell receptor has proclivity for T helper 9 cells, airway inflammation
7. Chronic inflammation in the brain leads the way to Alzheimers disease
8. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
9. Omega-3 lowers inflammation in overweight older adults
10. Intestinal bacteria produce neurotransmitter, could play role in inflammation
11. Modest alcohol intake associated with less inflammation in patients with common liver disease
Post Your Comments:
(Date:11/9/2015)... ) ... "Global Law Enforcement Biometrics Market 2015-2019" ... ) has announced the addition of ... 2015-2019" report to their offering. ... ) has announced the addition of the ...
(Date:10/29/2015)... Minn. , Oct. 29, 2015   MedNet ... supports the entire spectrum of clinical research, is pleased ... Minnesota High Tech Association (MHTA) as one of only ... in the "Software – Small and Growing" category. The Tekne ... individuals who have shown superior technology innovation and leadership. ...
(Date:10/29/2015)... -- Connected health pioneer, Joseph C. Kvedar , MD, ... and wellness, and the business opportunities that arise from ... of Healthy Things . Long before health and ... Kvedar, vice president, Connected Health, Partners HealthCare, was creating ... from the hospital or doctor,s office into the day-to-day ...
Breaking Biology News(10 mins):
(Date:11/24/2015)... , Nov. 24, 2015 Cepheid (NASDAQ: ... be speaking at the following conference, and invited investors ... York, NY      Tuesday, December 1, 2015 at ... York, NY      Tuesday, December 1, 2015 at ... Healthcare Conference, New York, NY ...
(Date:11/24/2015)... Nov. 24, 2015 /PRNewswire/ - Aeterna Zentaris Inc. (NASDAQ: ... on behalf of the Toronto Stock Exchange, confirms that ... are no corporate developments that would cause the recent ... --> --> About Aeterna Zentaris Inc. ... --> Aeterna Zentaris is a specialty biopharmaceutical ...
(Date:11/24/2015)... 24, 2015 SHPG ) announced today that ... Piper Jaffray 27 th Annual Healthcare Conference in ... at 8:30 a.m. EST (1:30 p.m. GMT). --> SHPG ... will participate in the Piper Jaffray 27 th Annual Healthcare ... Tuesday, December 1, 2015, at 8:30 a.m. EST (1:30 p.m. GMT). ...
(Date:11/24/2015)... ... November 24, 2015 , ... In harsh ... Insertion points for in-line sensors can represent a weak spot where leaking process ... series of retractable sensor housings , which are designed to tolerate extreme process ...
Breaking Biology Technology: