Navigation Links
Induction of mild inflammation leads to cognitive deficits related to schizophrenia
Date:2/6/2013

Researchers at the Institute for Comprehensive Medical Science, Fujita Health University and the National Institute for Physiological Sciences, Japan, along with colleagues from 9 other institutions, have identified an exceptional mouse model of schizophrenia. After screening over 160 mutant mouse strains with a systematic battery of behavioral tests, they identified a mutant mouse lacking the Schnurri-2 protein (Shn-2 KO) that exhibits behavioral deficits and other brain features consistent with schizophrenia. Shn-2 is an NF-B site-binding protein that binds enhancers of major histocompatibility complex class I genes and inflammatory cytokines, which harbor common variant single nucleotide polymorphisms associated with schizophrenia. The Shn-2 KO mice display behavioral abnormalities that resemble the symptoms of human schizophrenia, including working memory deficits, impaired nest building behavior (a measure of self-neglect), decreased social behaviors, and anhedonia (loss of the ability to experience pleasure).

Drs. Tsuyoshi Miyakawa, Keizo Takao, and their colleagues found that Shn-2 deficiency results in mild chronic brain inflammation, which leads to a unique alteration of a specific region in the brain, the dentate gyrus. The "immature Dentate Gyrus (iDG)", as it is referred to by the researchers, is presumed to produce schizophrenia-related phenotypes, such as working memory deficits and impaired nest-building behavior, as reported online February 6th in Neuropsychopharmacology.

The transcriptome patterns in the prefrontal cortex of the Shn-2 KO mice and post-mortem schizophrenia patients are surprisingly similar, with 100 commonly altered genes. Interestingly, 11 of the top 20 ranked genes with altered expression levels are involved in inflammatory or immune function. The brains of the mutant mice also exhibit numerous schizophrenia-related phenotypes, including decreased parvalbumin and GAD67 levels, increased theta and decre
'/>"/>

Contact: Prof. Tsuyoshi Miyakawa
miyakawa@fujita-hu.ac.jp
81-562-939-375
National Institute for Physiological Sciences
Source:Eurekalert

Page: 1 2

Related biology news :

1. Monitoring and robust induction of nephrogenic intermediate mesoderm from human iPSCs
2. FASEB SRC announces conference: Gastrointestinal Tract XV: Epithelia, Microbes, Inflammation & Cancer
3. Team finds a new way to inhibit blood clotting and inflammation
4. Inflammation and cognition in schizophrenia
5. A solution to reducing inflammation
6. Cell receptor has proclivity for T helper 9 cells, airway inflammation
7. Chronic inflammation in the brain leads the way to Alzheimers disease
8. La Jolla Institute scientist discovers key step in immune system-fueled inflammation
9. Omega-3 lowers inflammation in overweight older adults
10. Intestinal bacteria produce neurotransmitter, could play role in inflammation
11. Modest alcohol intake associated with less inflammation in patients with common liver disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/18/2014)... Half of the Earth,s land mass is made ... they are being transformed at an alarming rate. Woody ... and taking over, leading to a loss of critical ... of ecosystems to produce food specifically meat. ... Sciences led an investigation that quantified this loss in ...
(Date:8/18/2014)... Researchers from Aarhus University, Denmark, and the University of Wisconsin-Madison, ... exposure of species to both climate and land use change. ... species in the face of combined rates of climate and ... , Their results, which have just been published in ... vulnerable to losses in biodiversity and ecosystem function due to ...
(Date:8/18/2014)... the pygmy phenotype is probably a selective adaptation ... of researchers, but all African pygmy phenotypes do ... more recent adaptation than previously thought., "I,m interested ... very challenging environments," said George H. Perry, assistant ... rainforests are difficult for humans to live in. ...
Breaking Biology News(10 mins):Trees and shrubs invading critical grasslands, diminish cattle production 2Trees and shrubs invading critical grasslands, diminish cattle production 3The double threat of climate and land use change enhances risks to biodiversity 2Pygmy phenotype developed many times, adaptive to rainforest 2
... 28, 2007 - Sirtris Pharmaceuticals, Inc. (NASDAQ: SIRT), a ... drugs to treat diseases of aging, announced today that ... developed novel drug candidates that offer a promising, new ... Diabetes, by targeting SIRT1, a gene that controls the ...
... Although a high standard of morality gives but a ... his children over the other men of the same ... give an immense advantage to one tribe over another. ... an evolutionary explanation for morality and pro-social behaviors individuals ...
... able to form abstract concepts. Friederike Range and ... shown for the first time that dogs can classify ... the same way that humans do. And the ... computer automated touch-screens, eliminating potential human influence. The ...
Cached Biology News:Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging 2Sirtris unveils promising, novel SIRT1 activators for treating diseases of aging 3Group selection, a theory whose time has come...again 2Computer savvy canines 2
(Date:8/18/2014)... Global HIV Infection Drug Market and ... Reportstack. The rate of HIV infection and the number of ... at a positive rate across the globe. It has been ... 2005 to 1.5 in 2013, with the rates for children ... changes in the infection rates has been the improved access ...
(Date:8/18/2014)... 2014 According to the ... Application (Municipal Wastewater Treatment and Industrial Wastewater Treatment), ... Tubular), By Configuration (Internal/Submerged and External/Sidestream), and By ... The market for membrane bioreactor systems is projected ... a CAGR of 15.28% between 2014 and 2019. ...
(Date:8/18/2014)... JUPITER, Fla. , Aug. 18, 2014 /PRNewswire/ ... global biotechnology company whose patented and proprietary technologies ... and other proteins for the bioenergy, bio-based chemical, ... it has filed a Registration Statement on Form ... (the "SEC"). Logo - http://photos.prnewswire.com/prnh/20110621/CL06708LOGO ...
(Date:8/18/2014)... August 2014 Vier führende deutsche ... klinische Studie auf, in der eine Intraokularlinse ... das Sehvermögen bei allen Entfernungen verbessern, so ... keine Lese- oder Gleitsichtbrille mehr benötigen. Die ... FluidVision Accommodating Intraocular Lens (FluidVision akkomodative ...
Breaking Biology Technology:Global HIV Infection Drug Market Overview 2Global HIV Infection Drug Market Overview 3Global HIV Infection Drug Market Overview 4Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 2Membrane Bioreactor Systems Market Worth $2,927 Million by 2019 3Dyadic International Files Form 10 Registration Statement 2Dyadic International Files Form 10 Registration Statement 3Dyadic International Files Form 10 Registration Statement 4Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 2Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 3Implantation einer revolutionären akkommodativen Linse bei Katarakt-Patienten in deutschen Augenzentren im Rahmen einer internationalen klinischen Studie 4
... heat during the production of electricity could be ... via a technique developed by researchers with the ... Laboratory (Berkeley Lab) and the University of California ... this technology include DOEs hydrogen fuel cell-powered Freedom ...
... in the Philadelphia suburbs, with unique new capabilities enabled by Masimo ... ... technologies, IRVINE, Calif., Jan. 10 Abington Memorial,Hospital and ... & Low Perfusion Pulse Oximetry, have announced the,completion of Philadelphia-based Abington ...
... Ky., Lexington, Ky., and Newport News, Va. Also ... ... spirit of excellence and remarkable achievements in its,community, Harborview Medical Center of ... is one of the most esteemed,honors of excellence in community service in ...
Cached Biology Technology:Feeling the heat 2Feeling the heat 3Feeling the heat 4Abington Memorial Hospital Completes System-Wide Conversion to Masimo SET Pulse Oximetry Technology 2Abington Memorial Hospital Completes System-Wide Conversion to Masimo SET Pulse Oximetry Technology 3Abington Memorial Hospital Completes System-Wide Conversion to Masimo SET Pulse Oximetry Technology 4Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 2Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 3Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 4Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 5Harborview Medical Center in Seattle Receives Prestigious $100,000 Foster G. McGaw Prize for Excellence in Community Service 6
Gloves are 9.25 long, latex, powder free, smooth and ambidextrous....
Request Info...
Prepared with distilled water. Yeast extract solution is autolyzed at 150 g/L....
Streptomycin sulfate an aminoglycoside used for bacterial selection binds to the small ribosomal subunit and interferes with protein biosynthesis.21H39N7O12)2x3H2SO4Formula weight:...
Biology Products: