Navigation Links
Induced neural stem cells: Not quite ready for prime time
Date:2/15/2010

MADISON The great promise of induced pluripotent stem cells is that the all-purpose cells seem capable of performing all the same tricks as embryonic stem cells, but without the controversy.

However, a new study published this week (Feb. 15) in the Proceedings of the National Academy of Sciences comparing the ability of induced cells and embryonic cells to morph into the cells of the brain has found that induced cells even those free of the genetic factors used to program their all-purpose qualities differentiate less efficiently and faithfully than their embryonic counterparts.

The finding that induced cells are less predictable means there are more kinks to work out before they can be used reliably in a clinical setting, says Su-Chun Zhang, the senior author of the new study and a professor in the University of Wisconsin-Madison School of Medicine and Public Health.

"Embryonic stem cells can pretty much be predicted," says Zhang. "Induced cells cannot. That means that at this point there is still some work to be done to generate ideal induced pluripotent stem cells for application."

Scientists in the burgeoning field of regenerative medicine are pinning their hopes on induced stem cells because they offer advantages over embryonic stem cells, not the least of which is the fact that they do not need to be derived from early-stage human embryos.

The new Wisconsin study compared the ability of five embryonic stem cell lines with 12 induced cell lines coaxed into being using different methods. Embryonic stem cells are considered the "gold standard" for all pluripotent stem cells, which are cells that can differentiate into all of the 220 cell types in the human body.

Zhang's group, led by researcher Baoyang Hu, found that the induced cells differentiate into progenitor neural cells and further into the different kinds of functional neurons that make up the brain. However, that they do not faithfully m
'/>"/>

Contact: Su-Chun Zhang
zhang@waisman.wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tummy troubles -- gastrin key in bacterial-induced stomach cancer
2. Simple drug treatment may prevent nicotine-induced SIDS: Study
3. Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
4. International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
5. Did the North Atlantic fisheries collapse due to fisheries-induced evolution?
6. Yale team identifies key to potential new treatment for allergy-induced asthma
7. Risk of vibration-induced vascular injuries linked to vibration frequency differences
8. MDC researchers prevent virus induced myocarditis
9. Targeted drug therapy prevents exercise-induced arrhythmias
10. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
11. Case Western Reserve researchers looking at light-induced toxins in air and water
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/24/2014)... in December 2014, the 1U™ app has helped ... remember their usernames and passwords through replacing the antiquated system ... people who have struggled to remember usernames and passwords, ... on redefining identity, announced today that it is offering the ...
(Date:12/22/2014)...  The 2014 Holiday Season may be the brightest ever ... that the long anticipated floodgates for consumer biometrics may ... smart phones, tablets, and wearable mobile devices that incorporate ... users with nearly 4.8 billion biometric devices by 2020.   ...
(Date:12/19/2014)... Dec. 18, 2014  23andMe, Inc., the leading personal genetics company, ... differences in genetic ancestry of individuals from across ... arrived more than four hundred years ago, the ... for peoples from different continents. This study illuminates how American ...
Breaking Biology News(10 mins):1U Offers Best Solution to the Username / Password Dilemma: For FREE! 21U Offers Best Solution to the Username / Password Dilemma: For FREE! 3First Season of Holiday Shopping with Mobile Biometric Payments Wraps Up With a Present for Biometrics Industry: A Rosy Forecast for More Than 2 Billion Users of 4.8 Billion Mobile Biometric Devices by 2020 223andMe Study Sketches Genetic Portrait of the United States 223andMe Study Sketches Genetic Portrait of the United States 323andMe Study Sketches Genetic Portrait of the United States 4
... pioneer on synthetic biology who has engineered microbial "factories" ... drug and biofuel substitutes for gasoline, diesel and jet ... presented by the Heinz Family Foundation and carries with ... multiple titles, Keasling is the Associate Laboratory Director for ...
... research indicates marijuana-like compounds called endocannabinoids alter genes and ... placenta during pregnancy and may contribute to pregnancy complications ... edition of The Journal of Biological Chemistry ... lipid molecules produced by the body disrupts the movement ...
... A team of Australian researchers, led by University of Melbourne ... the risk of developing Autism Spectrum Disorder, ASD. Lead ... Engineering at the University of Melbourne said the test could ... "This test could assist in the early detection of ...
Cached Biology News:Jay Keasling wins Heinz Award 2Jay Keasling wins Heinz Award 3Jay Keasling wins Heinz Award 4Study implicates marijuana use in pregnancy problems 2Genetic test predicts risk for Autism 2
(Date:1/22/2015)... SAN DIEGO , Jan. 22, 2015   ... company, and Sequenom, Inc. (NASDAQ: SQNM ... a development agreement for next generation noninvasive prenatal ... Cypher,s genome interpretation technology, called Mantis™, to advance ...
(Date:12/25/2014)... The report “Service Quality Management and Telco ... Type - Global Advancements, Worldwide Forecasts & Analysis (2014-2019)” ... and forecasting of revenues. , Browse 152 market ... in-depth TOC on “Service Quality Management (SQM) and Telco ...
(Date:12/24/2014)... BioLife Solutions , Inc. (NASDAQ: BLFS ), a ... hypothermic storage and cryopreservation freeze media and ... ("BioLife" or the "Company"), today announced that it will hold ... (the "Annual Meeting"). Because the expected date for ...
(Date:12/24/2014)... (PRWEB) December 23, 2014 ... designed to introduce cutting edge communication technology, provide ... platform upgrades. This webinar series demonstrates online communication ... to leverage web conferencing’s most innovative and powerful ...
Breaking Biology Technology:Cypher Genomics and Sequenom Announce Development Agreement 2Cypher Genomics and Sequenom Announce Development Agreement 3Cypher Genomics and Sequenom Announce Development Agreement 4Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 2Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 3Service Quality Management Market worth $2.1 Billion & Telco Customer Experience Management Market worth $2.3 Billion by 2019 – New Report by MarketsandMarkets 4BioLife Solutions Sets Date for Annual Meeting of Stockholders 2SoundConnect Launches Leading Edge Business Communications Webinar Series 2SoundConnect Launches Leading Edge Business Communications Webinar Series 3
... - Covance Inc. has promoted Wendel Barr to the ... Anthony Cork to the position of president, early development, ... move supports the regional decision-making employed by its clients ... Tony have become corporate senior vice presidents and also ...
... Plan of New Jersey and announced an investment to ... Insurance Corp., Delta Dental Plan of Michigan, The Guardian ... Providers (the dental subsidiary of UnitedHealth Group). , ,These ... to enhance a platform that allows dentists to submit ...
... with innovation and excitement on its closing day, focusing ... next-generation systems designed to protect and defend the national ... email services. In addition to an array of new ... next "big thing" in a morning panel devoted to ...
Cached Biology Technology:Covance Appoints Co-Presidents for Early Development Services 2DEMO 2003 Closes with Focus on Collaboration and Communication 2DEMO 2003 Closes with Focus on Collaboration and Communication 3DEMO 2003 Closes with Focus on Collaboration and Communication 4
Request Info...
Phospho-TAO2 (S181) Affinity Purified Polyclonal Ab Protein Family: Other Intracellular Kinases...
PEG 8000 is used in the precipitation of phage, isolation of plasmid DNA and the enhancement of blunt-ended ligation reactions....
Recombinant Mouse Matrilin-4, CF Protein Family: Extracellular Matrix Molecules, Chondrogenesis Markers...
Biology Products: