Navigation Links
Induced neural stem cells: Not quite ready for prime time
Date:2/15/2010

MADISON The great promise of induced pluripotent stem cells is that the all-purpose cells seem capable of performing all the same tricks as embryonic stem cells, but without the controversy.

However, a new study published this week (Feb. 15) in the Proceedings of the National Academy of Sciences comparing the ability of induced cells and embryonic cells to morph into the cells of the brain has found that induced cells even those free of the genetic factors used to program their all-purpose qualities differentiate less efficiently and faithfully than their embryonic counterparts.

The finding that induced cells are less predictable means there are more kinks to work out before they can be used reliably in a clinical setting, says Su-Chun Zhang, the senior author of the new study and a professor in the University of Wisconsin-Madison School of Medicine and Public Health.

"Embryonic stem cells can pretty much be predicted," says Zhang. "Induced cells cannot. That means that at this point there is still some work to be done to generate ideal induced pluripotent stem cells for application."

Scientists in the burgeoning field of regenerative medicine are pinning their hopes on induced stem cells because they offer advantages over embryonic stem cells, not the least of which is the fact that they do not need to be derived from early-stage human embryos.

The new Wisconsin study compared the ability of five embryonic stem cell lines with 12 induced cell lines coaxed into being using different methods. Embryonic stem cells are considered the "gold standard" for all pluripotent stem cells, which are cells that can differentiate into all of the 220 cell types in the human body.

Zhang's group, led by researcher Baoyang Hu, found that the induced cells differentiate into progenitor neural cells and further into the different kinds of functional neurons that make up the brain. However, that they do not faithfully m
'/>"/>

Contact: Su-Chun Zhang
zhang@waisman.wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2

Related biology news :

1. Tummy troubles -- gastrin key in bacterial-induced stomach cancer
2. Simple drug treatment may prevent nicotine-induced SIDS: Study
3. Researchers engineer metabolic pathway in mice to prevent diet-induced obesity
4. International Serious Adverse Events Consortium announces initial study results in its global research collaboration to identify genetic markers related to drug induced liver injury
5. Did the North Atlantic fisheries collapse due to fisheries-induced evolution?
6. Yale team identifies key to potential new treatment for allergy-induced asthma
7. Risk of vibration-induced vascular injuries linked to vibration frequency differences
8. MDC researchers prevent virus induced myocarditis
9. Targeted drug therapy prevents exercise-induced arrhythmias
10. HIV-1 protease inhibitor induced oxidative stress in pancreatic B-cells: thymoquinone protection
11. Case Western Reserve researchers looking at light-induced toxins in air and water
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... , Aug. 31, 2015 Research and Markets ... "Saudi Arabia Biomedical Sensors Market - Growth, Trends ... The Saudi Arabia Biomedical Sensors market is ... of 3.64% over the period 2014-2020 The ... to the genetic formulation of each individual. These sensors ...
(Date:8/26/2015)... PUNE, India , August 26, 2015 ... (Two, Three, Four, and Five Factor), Application (Travel & ... and Geography - Global Forecast to 2020", published by ... 9.60 Billion by 2020, growing at a CAGR of ... 71 Tables and 82 F igures spread through ...
(Date:8/24/2015)... , August 24, 2015 The ... ,s largest biometrics manufacturer DERMALOG and its customized solutions ... "2015 African Biometrics Company of the Year Award". DERMALOG is ... Nigeria .   -Cross reference: Picture is ... - On Thursday evening, in ...
Breaking Biology News(10 mins):Saudi Arabia Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts (2014-2020) 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 2Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 3Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 4Multi-Factor Authentication Market Worth 9.60 Billion USD by 2020 5Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 2Frost & Sullivan Honors DERMALOG with Biometrics Prize for Achievements in Africa 3
... on their healthcare providers to learn about gynecological issues, ... to them about cervical cancer and its cause - ... survey released by the Association of Reproductive Health Professionals ... percent of sexually active adults in their lifetime, in ...
... cause of chronic sinus infections lies in the nasal mucus ... tissue targeted by standard treatment. The findings will be published ... Immunology and are available online . , "This strikingly ... of chronic sinus infection: that inflammatory cells break down, releasing ...
... made a major discovery on the inner workings of genetic ... functions: RNA synthesis. Their work has crucial implications for how ... runs amok. , The work is published in the May ... the basic research is a story that melds exquisite nanotechnology ...
Cached Biology News:Survey reveals women and doctors aren't talking about HPV 2Survey reveals women and doctors aren't talking about HPV 3Chronic Sinus Infection Thought To Be Tissue Issue, Mayo Clinic Scientists Show It's Snot 2High fidelity keeps human DNA assembly line humming 2
(Date:8/31/2015)... , Aug. 31, 2015 Research and ... the "Middle East & Africa Biomedical Sensors Market ... their offering. The Middle ... estimated at $0.84 billion by 2018 at a CAGR ... near future will bring Biomedical sensors that are adaptable ...
(Date:8/31/2015)... and SHANGHAI , Aug. ... biopharmaceutical company developing next-generation antibiotics, today announced positive ... study for its lead drug candidate MRX-I. MRX-I ... drug-resistant bacteria such as MRSA and VRE, while ... tolerated therapeutic option than currently available oxazolidinone agents. ...
(Date:8/31/2015)... ... August 31, 2015 , ... The Food Processing Suppliers ... beverage processors, equipment manufacturers and leaders in the field of academia. , ... formulation for manufacturers of bakery and snacks; beverages; dairy; meat, poultry and seafood; ...
(Date:8/28/2015)... According to a new market ... Systems, Thawing Equipment, Alarms), by Biospecimen (Human Tissue, Stem ... User - Global Forecast to 2020", published by MarketsandMarkets, ... 3,731.03 Million by 2020 from USD 2,150.48 Million in ... and 2020. Browse 74 Tables and ...
Breaking Biology Technology:Middle East & Africa Biomedical Sensors Market Report 2015 - Growth, Trends & Forecasts to 2020 2MicuRX Reports Positive Top-Line Results In Phase 2 Clinical Trial For Novel Antibiotic MRX-I In Complicated Skin And Soft Tissue Infections 2METTLER TOLEDO Hosts Food Safety Educational Center at 2015 PROCESS EXPO 2Biopreservation Market Worth 3,731.03 Million USD by 2020 2Biopreservation Market Worth 3,731.03 Million USD by 2020 3Biopreservation Market Worth 3,731.03 Million USD by 2020 4Biopreservation Market Worth 3,731.03 Million USD by 2020 5
... MediTech,Company, a Shanghai-based drug discovery and pharmaceutical development,outsourcing ... 50 China award, and ranked number 16. The ... announced today in Shenzhen, China at,a special ceremony., ... 1995 in San Jose. This,program quickly expanded to ...
... Brint, Daniel Durrie, Shachar Tauber, Stephen Slade, R. ... Jason Stahl, Karl Stoneciper, Brock Magruder, and Richard ... Texas, which featured the Allegretto Wave excimer laser ... of these LASIK eye surgeons and refractive experts ...
... in health care, employment continued to increase in September, gaining 17,000 jobs ... searching for those new jobs. , ... Seattle, WA (Vocus) October 31, ... average of 30,000 jobs created each month. Even with layoff announcements from ...
Cached Biology Technology:Sundia MediTech Ranked #16 in Deloitte Technology Fast 50 China 2Top Refractive Eye Surgeons Listed in Trusted LASIK Surgeons Directory Make Solid Showing at Annual Alcon Symposium 2Top Refractive Eye Surgeons Listed in Trusted LASIK Surgeons Directory Make Solid Showing at Annual Alcon Symposium 3Top Refractive Eye Surgeons Listed in Trusted LASIK Surgeons Directory Make Solid Showing at Annual Alcon Symposium 4Top Refractive Eye Surgeons Listed in Trusted LASIK Surgeons Directory Make Solid Showing at Annual Alcon Symposium 5Top Refractive Eye Surgeons Listed in Trusted LASIK Surgeons Directory Make Solid Showing at Annual Alcon Symposium 6Top Refractive Eye Surgeons Listed in Trusted LASIK Surgeons Directory Make Solid Showing at Annual Alcon Symposium 7Top Refractive Eye Surgeons Listed in Trusted LASIK Surgeons Directory Make Solid Showing at Annual Alcon Symposium 8The MedZilla Report: September 2008 Employment Outlook for Biotech/Pharma/Health 2The MedZilla Report: September 2008 Employment Outlook for Biotech/Pharma/Health 3
NATIVE, ENZYME PORCINE TRYPSIN...
G-Protein Coupled Receptor Assay, For 500 assays. SPA. Category: Drug Screening & Cellular Assays, Assays ....
EDTA, disodium salt, 1 kg. Ethylene diaminetetraacetic acid.Dihydrate. Assay: 99.0-101.0%, nuclease-free.Risks: 36, 37, 38 ; Safety Precautions: 22, 36, 37. Category: Nucleotides & Enzymes & Biochemi...
Alkaline Phosphatase Stabilizer Solution, 1 L...
Biology Products: