Navigation Links
Individual cells isolated from biological clock can keep daily time, but are unreliable
Date:9/9/2009

Alexis Webb enters a small room at Washington University in St. Louis with walls, floor and ceiling painted dark green, shuts the door, turns off the lights and bends over a microscope in a black box draped with black cloth. Through the microscope, she can see a single nerve cell on a glass cover slip glowing dimly.

The glow tells her the isolated nerve cell is busy keeping time.

Webb, a graduate student in the neuroscience program, working with Erik Herzog, Ph.D., associate professor of biology in Arts & Sciences; Nikhil Angelo, an undergraduate biology major; and James Huettner, Ph.D., associate professor of cell biology and physiology in the School of Medicine, has demonstrated that individual cells isolated from the biological clock can keep daily time all by themselves.

However, by themselves, they are unreliable. The neurons get out of synch and capriciously quit or start oscillating again.

The biological clock, a one-square millimeter area of the brain called the suprachiasmic nucleus, or SCN, just above the roof of the mouth and atop the crossing of the optic nerves, comprises about 20,000 neurons.

These cells, remarkably, contain the machinery to generate daily, or circadian, rhythms in gene expression and electrical activity. But the individual cells are sloppy and must communicate with one another to establish a coherent 24-hour rhythm, says Herzog.

These features make the SCN a flexible clock that can reset to stay in synch in an ever-changing environment. The underlying sloppiness is probably what allows us to adjust to local time when we cross time zones and to vary our sleep cycles with the season, say the WUSTL researchers.

The research is being published the week of Sept. 7 in the online Early Edition of the Proceedings of the National Academy of Sciences.

"We've known for more than 15 years that unicellular organisms like cyanobacteria can keep 24-hour time, and iso
'/>"/>

Contact: Erik Herzog
herzog@biology.wustl.edu
314-935-8635
Washington University in St. Louis
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. First individual genome sequence published
2. New book presents methods to poke and prod individual molecules
3. Jingle bells not merry for tone-deaf individuals
4. 1 person out of every 1,000 has synaesthesia, in which an individual can smell a sound
5. Nanoglassblowing seen as boon to study of individual molecules
6. Caltech neurobiologists discover individuals who hear movement
7. Individuals vary their immune response according to age, sex and the costs
8. Scripps research scientists watch as individual alpha-synuclein proteins change shape
9. Researchers find snippet of RNA that helps make individuals remarkably alike
10. Study finds link between individual stress and adolescent obesity
11. ESF EURYI award winner aims to stop cancer cells reading their own DNA
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... at the University of California, San Diego, have completed ... using a method that uses the pixels in an ... known as mesh-free simulation. , The researchers, led by ... at the Jacobs School of Engineering at UC San ... method at the CompIMAGE,14 conference in Pittsburgh this month. ...
(Date:9/30/2014)... comprehensive assessment conducted by the Ocean Health Index ... 100 in overall health. In addition, for the ... the 15 ocean regions beyond national jurisdiction (high-seas ... healthy climate, safeguarding biodiversity and providing sustainable food ... the index, a partnership led by scientists from ...
(Date:9/30/2014)... 30, 2014--Sea monkeys have captured the popular attention of ... observable life cycle -- sold as dehydrated eggs, these ... little more than a tank of salt water. ... Like other zooplankton, brine shrimp vertically migrate in large ... to the surface at night and retreating deeper during ...
Breaking Biology News(10 mins):First comprehensive meshfree numerical simulation of skeletal muscle tissue achieved 2Rating the planet's oceans 2Rating the planet's oceans 3Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2
... French . , Two McGill researchers have ... Fellowships. Dr. Andrew P. Hendry an associate professor with ... Dr. Karim Nader, an associate professor and Willam Dawson ... the prestigious fellowships from the Natural Sciences and Engineering ...
... emotional toll on our bodies and scientists are working on ... to stress at the cellular level in the brain. ... essential for survival. Using a rat model, Jaideep ... of researchers at the Hotchkiss Brain Institute have discovered that ...
... for pregnant women and their children, and vitamin B12 ... any common multivitamin, say doctors and dietitians with the ... are available for comment in response to a new ... vitamin B12 may increase the risk for neural tube ...
Cached Biology News:2 McGill researchers garner prestigious NSERC Steacie Fellowships 2New and unexpected mechanism identified how the brain responds to stress 2Doctors endorse vegan and vegetarian diets for healthy pregnancies 2
(Date:10/1/2014)... Jolla, Calif. (PRWEB) September 30, 2014 ... announced the initial round of grants for the ... an undertaking that aims to develop and revolutionize ... circuit functions of the human brain. This first ... for fiscal year 2014 was allocated to more ...
(Date:10/1/2014)... Centreville, VA (PRWEB) October 01, 2014 ... the Diagnostic, Clinical Therapeutics, Healthcare IT, and Laboratory Testing ... and regulatory positions at the director level and above ... payers struggling to stay on top of rapid breakthroughs ... a result, many diagnostic companies have been forced to ...
(Date:10/1/2014)... , October 1, 2014 ... software invited to engage around the theme, ,Commercial Opportunities ...   Elsevier , a ... and services, will host a gathering of some of ... and trends impacting healthcare today and in the future. ...
(Date:9/30/2014)... Mass. Using a bio-mimicking analog of one ... grass, an international research team led by Alejandro ... taken a major step in developing long-sought polymer ... electricity for use in electronic devices. , ... Amherst and others at Stanford University and Dresden ...
Breaking Biology Technology:NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 2NIH Awards 15 Grants to CHI Members for BRAIN Initiative Research 3Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 2Elsevier Healthcare and Pharmaceutical Economics Conference 2014 To Convene Industry Leaders to Discuss Top Healthcare Business Issues 3Blades of grass inspire advance in organic solar cells 2Blades of grass inspire advance in organic solar cells 3
... Bethany V. Pond, Jason S. Wood, ... Introduction , ... Serum Albumin (BSA) matrix, both before and after protein precipitation using ... Varian 500-MS IT Mass Spectrometer to detect and accurately quantitate these ...
... Jason S. Wood, Ph.D. Varian, Inc. , ... Testing for drugs of abuse (DoA) is becoming more ... well as in sporting events. Non-heroin opiates such as morphine, oxycodone, ... in San Francisco, the number of emergency department mentions of oxycodone ...
... , fusions in lysates of the yeast Saccharomyces cerevisiae ... Cary Eclipse , Paul Gavin # ... Daren J. Fyfe, Ph.D* , # ... Clayton campus Victoria 3800, Australia , * ...
Cached Biology Technology:Detection of Alprazolam and Temazepam in a Bovine Plasma Matrix Using the Varian 500-MS Ion Trap Mass Spectrometer 2Detection of Alprazolam and Temazepam in a Bovine Plasma Matrix Using the Varian 500-MS Ion Trap Mass Spectrometer 3Detection of Morphine and Morphine-Glucuronide in Saliva or Urine with a Rapid and Simple Method Without Derivatization on the Varian 500-MS 2Detection of Morphine and Morphine-Glucuronide in Saliva or Urine with a Rapid and Simple Method Without Derivatization on the Varian 500-MS 3Detection of Morphine and Morphine-Glucuronide in Saliva or Urine with a Rapid and Simple Method Without Derivatization on the Varian 500-MS 4 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 2 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 3 Monitoring fluorescence resonance energy transfer (FRET) between GFP, fusions in lysates of the yeast Saccharomyces cerevisiae using the , Varian, Cary Eclipse 4
... surface is produced by a patented microwave ... giving more consistent, even cell attachment, increased ... attachment and growth uunder difficult conditions, including ... may provide a more ecominic alternative to ...
Automated Cell Culture Flask...
... 100-240 V, uses xMAP technology for simultaneous ... and peptides in one microplate well. The ... 100 color-coded bead sets, each of which ... (enzyme substrates, receptors, antigens, or antibodies) specific ...
Cell Culture Flask, 75 cm, treated polystyrene...
Biology Products: