Navigation Links
Increased nicotine levels detected in those who light-up earlier
Date:12/2/2009

PHILADELPHIA People who smoke their first cigarette within minutes after waking up have much higher levels of cotinine, a by-product of nicotine when processed by the body, than those who wait to smoke, regardless of the number of cigarettes smoked.

"Since cotinine levels appear to reflect the risk of lung cancer, our results suggest that smokers who smoke immediately after waking may be especially at risk for lung cancer," said researcher Joshua E. Muscat, Ph.D., M.P.H., professor of public health sciences at Penn State College of Medicine. "These people may require a more intensive intervention than other smokers to help them quit smoking on a sustained or permanent basis."

Results of this study are published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research, as part of a special tobacco focus in the December issue.

Nicotine levels in the blood can be measured biochemically by the concentration of the metabolite cotinine. Muscat, along with John P. Richie, Jr., Ph.D., professor of public health sciences and pharmacology at Penn State College of Medicine, and colleagues conducted a community-based study in Westchester County, N.Y., to examine whether a behavioral aspect of nicotine dependence (the amount of time to the first cigarette after waking up) affects the physiological uptake of nicotine. This in turn may affect one's success in quitting smoking and have multiple health effects, such as lung cancer.

The study included 252 healthy black and white people who were daily cigarette smokers. Researchers examined a number of behavioral factors that are thought to measure the urge to smoke, and results showed a clear trend between lighting-up earlier and higher cotinine levels.

Cotinine levels varied from 16 ng/mL to 1180 ng/mL a 74-fold difference, according to the study. Participants who waited 30 minutes or more were categorized into the "low" dependant phenotype; those who smoked within the first 30 minutes of waking were considered "high." Number of cigarettes smoked per day and its association with cotinine levels varied as well.

"Not all smokers are the same and approaches to smoking reduction may need to account for individual smoking behaviors such as the intensity and frequency of puffing, cravings and physiological symptoms," said Muscat. "It is unclear why smokers who take their first puff immediately after waking have higher cotinine levels, but this may reflect a more intense pattern of smoking. We need to find out why this is."

The researchers are currently conducting follow-up studies to investigate levels of additional nicotine metabolites that will further confirm this association and help determine the impact of time to first cigarette as a novel risk factor for lung cancer.


'/>"/>

Contact: Tara Yates
tara.yates@aacr.org
267-646-0558
American Association for Cancer Research
Source:Eurekalert  

Related biology news :

1. Western diet linked to increased risk of colon cancer recurrence
2. International team shows mercury concentrations in fish respond quickly to increased deposition
3. International team shows mercury concentrations in fish respond quickly to increased deposition
4. Weight gain between first and second pregnancies associated with increased odds of male second child
5. Social stress + darkness = increased anxiety
6. Baker Institute finds increased domestic production wont make US self-sufficient in natural gas
7. Research forecasts increased chances for stormy weather
8. Poultry workers at increased risk of carrying antibiotic-resistant E. coli
9. Study shows immigrant children are at increased risk of lead poisoning
10. First-ever study to link increased mortality specifically to carbon dioxide emissions
11. Environmental groups call for increased protection of coral reefs
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Increased nicotine levels detected in those who light-up earlier
(Date:5/16/2017)... -- Veratad Technologies, LLC ( www.veratad.com ), an innovative and ... solutions, announced today they will participate as a sponsor ... May 17, 2017, in Washington D.C.,s ... Identity impacts the lives of billions of ... digital world, defining identity is critical to nearly every ...
(Date:5/6/2017)... -- RAM Group , Singaporean based technology ... biometric authentication based on a novel  quantum-state ... perform biometric authentication. These new sensors are based on a ... Group and its partners. This sensor will have widespread ... security. Ram Group is a next generation sensor ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... October 11, 2017 , ... ... has granted orphan drug designation to SBT-100, its novel anti-STAT3 (Signal Transducer and ... of osteosarcoma. SBT-100 is able to cross the cell membrane and bind intracellular ...
(Date:10/10/2017)... Poway, California (PRWEB) , ... October 10, 2017 , ... ... afternoon speaking at his local San Diego Rotary Club. The event ... San Diego, CA and had 300+ attendees. Dr. Harman, DVM, MPVM was joined ...
(Date:10/10/2017)... , ... October 10, 2017 , ... ... of 13 prestigious awards honoring scientists who have made outstanding ... a scheduled symposium during Pittcon 2018, the world’s leading conference and exposition for ...
(Date:10/9/2017)... Phoenix, Arizona (PRWEB) , ... October 09, 2017 ... ... of Kindred, a four-tiered line of medical marijuana products targeting the needs of ... production and packaging of Kindred takes place in Phoenix, Arizona. , As operators ...
Breaking Biology Technology: