Navigation Links
Increased likelihood of male death from disease
Date:6/18/2010

Research currently being undertaken at the University of Leicester may identify reasons underlying an increased risk of Abdominal Aortic Aneurysms (AAA) in men.

In her doctoral study, Cardiovascular Sciences student Lisa Bloomer is looking into the causes of the male predominance of AAA, with a particular emphasis on genetic basis of the disease. Preliminary results from the study will be showcased at the University of Leicester's Festival of Postgraduate Research on 24 June.

Miss Bloomer commented:

"AAA is the ballooning of the abdominal part of the major artery in the body. Rupturing of the weakened artery causes death in 80% of cases due to massive blood loss. The Y chromosome, which is present exclusively in men, may hold the key to deciphering why AAA has a 50% higher diagnosis rate in men than women.

"Staggeringly, AAA kills 10,000 men each year in England and Wales alone. The male-specific Y chromosome is a prime genetic suspect in AAA development, possibly acting as an independent risk factor."

A thorough DNA analysis tracking the most common forms of the Y chromosome amongst British men with AAA and those who are free of the disease is to be undertaken. It is hoped that the results from this research will be able to identify those individuals with a higher risk of developing AAA due to their Y chromosome.

"We anticipate that certain forms of the Y chromosome will be more common in those with AAA than across the general population. Elucidation of a specific form of Y chromosome which significantly increases the risk of AAA development in men could potentially save thousands of lives each year."

Lisa's doctoral supervisor, Dr Maciej Tomazewski, Senior Lecturer in Cardiovascular Medicine, commented:

"The major portion of the Y chromosome, the male specific region, is inherited intact from fathers to sons. Tracking the paternal lineages of this region has proved to be successful in our previous studies on coronary artery disease. Lisa's project is the first investigation that is using this strategy in relation to AAA."


'/>"/>

Contact: Lisa Bloomer
ldsb1@le.ac.uk
University of Leicester
Source:Eurekalert

Related biology news :

1. FASEB Scientists Descend on Capitol Hill to Advocate for Increased Science Funding
2. FASEB Scientists Descend on Capitol Hill to Advocate for Increased Science Funding
3. Young people with inflammatory bowel diseases are at increased risk of fracture
4. Long-term use of certain contraception injections associated with increased fracture risk
5. New gene associated with increased risk of Alzheimers disease
6. UV exposure has increased over the last 30 years, but stabilized since the mid-1990s
7. Sea lice treatment increased in Norwegian fish breeding in 2009
8. Study shows woody plant encroachment has increased stream flow in the Edwards Plateau
9. Extremes of sleep related to increased fat around organs
10. Industrial cleaner linked to increased risk of Parkinsons disease
11. Increased Spending on the EUs External Borders to Drive the Border Security Market, Says Frost & Sullivan
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2016)... 2016  IMPOWER physicians supporting Medicaid patients in ... clinical standard in telehealth thanks to a new partnership ... platform, IMPOWER patients can routinely track key health measurements, ... index, and, when they opt in, share them with ... a local retail location at no cost. By leveraging ...
(Date:3/29/2016)... 2016 LegacyXChange, Inc. (OTC: ... SelectaDNA/CSI Protect are pleased to announce our successful effort ... variety of writing instruments, ensuring athletes signatures against counterfeiting ... from athletes on LegacyXChange will be assured of ongoing ... Bill Bollander , CEO states, "By ...
(Date:3/22/2016)... PROVO and SANDY, Utah ... Ontario (NSO), which operates the highest sample volume laboratory ... and Tute Genomics and UNIConnect, leaders in clinical sequencing ... announced the launch of a project to establish the ... panel. NSO has been contracted by ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... 23, 2016   Boston Biomedical , an ... designed to target cancer stemness pathways, announced that ... Orphan Drug Designation from the U.S. Food and ... cancer, including gastroesophageal junction (GEJ) cancer. Napabucasin is ... inhibit cancer stemness pathways by targeting STAT3, and ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... ... Plate® YM (Yeast and Mold) microbial test has received AOAC Research Institute approval ... of microbial tests introduced last year,” stated Bob Salter, Vice President of Regulatory ...
(Date:6/23/2016)... , June, 23, 2016  The Biodesign Challenge ... envision new ways to harness living systems and biotechnology, ... Art (MoMA) in New York City ... 130 participating students, showcased projects at MoMA,s Celeste Bartos ... Paola Antonelli , MoMA,s senior curator of architecture and ...
Breaking Biology Technology: