Navigation Links
Increase in visceral fat during menopause linked with testosterone
Date:8/20/2009

In middle-aged women, visceral fat, more commonly called belly fat, is known to be a significant risk factor for cardiovascular disease, but what causes visceral fat to accumulate?

The culprit is likely not age, as is commonly believed, but the change in hormone balance that occurs during the menopause transition, according to researchers at Rush University Medical Center.

"Of all the factors we analyzed that could possibly account for the increase in visceral fat during this period in a woman's lifetime, levels of active testosterone proved to be the one most closely linked with abdominal fat," said Imke Janssen, PhD, assistant professor of preventive medicine and the study's lead investigator.

The study, which has been published early online in the medical journal Obesity, included 359 women in menopausal transition, ages 42 to 60, about half black and half white. Fat in the abdominal cavity was measured with CT scans, a more precise measurement than waist size. Blood tests were used to assess levels of testosterone and estradiol (the main form of estrogen). Medical histories covered other health factors possibly linked with an increase in visceral fat.

Statistical analyses showed that the level of "bioavailable" testosterone, or testosterone that is active in the body, was the strongest predictor of visceral fat.

A woman's age did not correlate significantly with the amount of visceral fat. Nor did race or other cardiovascular risk factors.

The level of estradiol also bore little relationship to the amount of visceral fat.

Visceral fat, surrounding internal organs around the waistline, is metabolically different from subcutaneous fat, which is fat located beneath the skin. Research has shown that visceral fat is a source of inflammation that contributes to premature atherosclerosis and risk of acute coronary syndrome.

The study's findings extend earlier research conducted by Janssen on testosterone's link with what is called the metabolic syndrome during the menopausal transition, published in the Archives of Internal Medicine in 2008. That study, examining women six years before and six years after their final menstrual period, found that the rise in metabolic syndrome a collection of risk factors for heart disease corresponded with the rise in testosterone activity.

"For many years, it was thought that estrogen protected premenopausal women against cardiovascular disease and that the increased cardiovascular risk after menopause was related only to the loss of estrogen's protective effect," said Janssen. "But our studies suggest that in women, it is the change in the hormonal balance specifically, the increase in active testosterone that is predominantly responsible for visceral fat, and for the increased risk of cardiovascular disease."


'/>"/>

Contact: Sharon Butler
Sharon_Butler@rush.edu
312-942-7816
Rush University Medical Center
Source:Eurekalert

Related biology news :

1. Increased climate volatility expected to worsen poverty vulnerability in developing countries
2. Severe breathing disorders during sleep are associated with an increased risk of dying
3. Inherited risk factors increase odds of developing childhood acute lymphoblastic leukemia
4. Moving to the US increases cancer risk for Hispanics
5. Wildfires set to increase 50 percent by 2050
6. Journal of Vascular and Interventional Radiology increases impact, international reach
7. UT multimedia program increases middle school interest in science
8. New biomarker method could increase the number of diagnostic tests for cancer
9. Purple sweet potato means increased amount of anti-cancer components
10. Researcher finds Girl Scout meetings provide an opportunity to increase girls physical activity
11. The battle for CRTC2: How obesity increases the risk for diabetes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... NEW YORK , Feb. 2, 2016 ... healthcare facilities are primarily focused on medical ... that measure point-of-care parameters. Wearable devices that ... a user,s freedom of movement are being ... sensors for human biomedical signal acquisition coupled ...
(Date:2/2/2016)... 2, 2016  Based on its recent analysis ... recognizes US-based Intelligent Retinal Imaging Systems (IRIS) with ... for New Product Innovation. IRIS, a prominent cloud-based ... America , is poised to set the ... retinopathy market. The IRIS technology presents superior price-performance ...
(Date:1/27/2016)... , Jan. 27, 2016  Rite Track, Inc. ... in West Chester, Ohio announced ... winning service staff, based in Austin, Texas ... and ability to provide modifications, installations and technical support ... , CEO of PLUS, commented, "PLUS has provided world ...
Breaking Biology News(10 mins):
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016  Bioethics International, ... how medicines are researched, developed, marketed and made accessible to ... BMJ Open had named the publication of the ... for 2015. The publication is also featured as one of ... published in the last year that are most frequently read. ...
(Date:2/11/2016)... 2016  Dovetail Genomics™ LLC today announced that it ... a planned metagenomic genome assembly service. Richard Green ... assembly method in a talk on Friday, February 12 ... conference in Orlando, Fla. ... is difficult. Using its proprietary Chicago ...
(Date:2/11/2016)... (PRWEB) , ... February 11, 2016 , ... ... regenerative medicine, has announced a new agreement with Bankok,Thailand-based Global Stem Cells Network ... and phsyicians in 15 Latin American countries, including Mexico, Costa Rica, Dominican Republic, ...
(Date:2/10/2016)... -- The Maryland House of Delegates and House Speaker ... Maryland School of Medicine Dean E. Albert Reece ... System President and CEO Robert Chrencik , MBA, ... given to the public by the leader of the ... and Mr. Chrencik for their contributions to our statewide ...
Breaking Biology Technology: