Navigation Links
In what ways does lead damage the brain?
Date:2/29/2012

NEW YORK (Feb. 29, 2012)Exposure to lead wreaks havoc in the brain, with consequences that include lower IQ and reduced potential for learning. But the precise mechanism by which lead alters nerve cells in the brain has largely remained unknown.

New research led by Toms R. Guilarte, PhD, Leon Hess Professor and Chair of Environmental Health Sciences at Columbia University Mailman School of Public Health, and post-doctoral research scientist Kirstie H. Stansfield, PhD, used high-powered fluorescent microscopy and other advanced techniques to painstakingly chart the varied ways lead inflicts its damage. They focused on signaling pathways involved in the production of brain-derived neurotropic factor, or BDNF, a chemical critical to the creation of new synapses in the hippocampus, the brain's center for memory and learning.

The study appears online in the journal Toxicological Sciences.

Once BDNF is produced in the nucleus, explains Dr. Stansfield, it is transported as cargo in a railroad-car-like vesicle along a track called a microtubule toward sites of release in the axon and dendritic spines. Vesicle navigation is controlled in part through activation (phosphorylation) of the huntingtin protein, which as its name suggests, was first identified through research into Huntington's disease. By looking at huntingtin expression, the researchers found that lead exposure, even in small amounts, is likely to impede or reverse the train by altering phosphorylation at a specific amino acid.

The BDNF vesicle transport slowdown is just one of a variety of ways that lead impedes BDNF's function. The researchers also explored how lead curbs production of BDNF in the cell nucleus. One factor, they say, may be a protein called methyl CpG binding protein 2, or MeCP2, which has been linked with RETT syndrome and autism spectrum disorders and acts to "silence" BDNF gene transcription.

The paper provides the first comprehensi
'/>"/>

Contact: Timothy S. Paul
tp2111@columbia.edu
212-305-2676
Columbia University's Mailman School of Public Health
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study says overweight Americans may risk kidney damage when attempting weight loss
2. Drug halts organ damage in inflammatory genetic disorder
3. Heat and cold damage corals in their own ways, Scripps study shows
4. European Research Council supports search for regulators of tissue damage
5. Oxidative DNA damage repair
6. New international Ph.D. program on Dynamics of Gene Regulation, Epigenetics and DNA Damage Response
7. Adult stem cells use special pathways to repair damaged muscle, MU researchers find
8. Brain, repair thyself: Studies highlight brains resiliency to damage
9. Scarring a necessary evil to prevent further damage after heart attack
10. New report offers broad approach to assessing impacts of ecological damage
11. Rutgers neuroscientist says protein could prevent secondary damage after stroke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... functions in an organism. For example, they catalyze ... control immune system responses. Researchers established some years ... each other, but instead form complex networks. , ... many similarities with online social networks," says Dr. ... Biology. "Some proteins are good networkers that maintain ...
(Date:9/16/2014)... of wild foods, autumn harks a season of bounty. ... luring intrepid collectors to woodlands in search of elusive ... in the allure of the treasure hunt, and their ... existence. But are the mushrooms which you are eating ... diverse yet vastly underdocumented although some estimates range ...
(Date:9/15/2014)... evolved a simple, mechanical solution to avoid chromosome ... Science Express. , This ... that lead to infertility, miscarriage, or congenital conditions. ... these problems, but what exactly goes wrong is ... Wellcome Trust Center for Cell Biology at the ...
Breaking Biology News(10 mins):Good networkers make prime targets 2What's for dinner? Rapidly identifying undescribed species in a commercial fungi packet 2What's for dinner? Rapidly identifying undescribed species in a commercial fungi packet 3Cells simply avoid chromosome confusion 2Cells simply avoid chromosome confusion 3
... 2008 A Webinar hosted by TorreyPines Therapeutics, Inc. ... will bring together industry experts to discuss the ... through the inhibition of the neurotransmitter glutamate. The ... will moderate a discussion following brief presentations by: ...
... span the globe and beyond, covering southern Africa,s diamond ... in the Wyoming badlands, glacial erosion in East Greenland, ... rhinoceroses in Ukraine, gold nanoparticles in Australia, and the ... GSA TODAY contains the first authoritative geological and ...
... future of high-intensity x-ray science has never been brighter ... National Laboratory have devised a new type of next ... (X-FELO) we are proposing can create x-rays up to ... Argonne Distinguished fellow Kwang-Je Kim said. Current technology ...
Cached Biology News:Treating chronic pain, migraine & muscle spasticity through inhibition of neurotransmitter glutamate 2Treating chronic pain, migraine & muscle spasticity through inhibition of neurotransmitter glutamate 3July 2008 GEOLOGY and GSA Today media highlights 2July 2008 GEOLOGY and GSA Today media highlights 3July 2008 GEOLOGY and GSA Today media highlights 4July 2008 GEOLOGY and GSA Today media highlights 5July 2008 GEOLOGY and GSA Today media highlights 6July 2008 GEOLOGY and GSA Today media highlights 7July 2008 GEOLOGY and GSA Today media highlights 8A novel X-ray source could be brightest in the world 2
(Date:9/15/2014)... 15, 2014 Bioptigen announced ... OCT system for the optical device metrology and pre-clinical ... S4410 SDOCT for Contact Lens Metrology is designed ... high complexity contact lens, IOL structures, and donor tissues. ... complete contact lens immersed in a hydration bath (saline), ...
(Date:9/15/2014)... September 15, 2014 Applied Silicone ... silicones for the medical device and critical healthcare ... for the implantable medical device market. The ... technology delivering a silicone gel with improved fracture ... Matrix technology consists of two crosslinked networks working ...
(Date:9/15/2014)... Hydro Dynamics, Inc. (HDI) of ... it will be partnering with Proteaf Technologies (Proteaf) ... for implementing its Shock Wave Power Reactor (SPR) ... Continuous flow chemistry through process intensification has been ... markets for decades. The continuous chemistry has ...
(Date:9/12/2014)... using an electric field (magnetoelectric memory [MEM] effect), ... technology for information processing and storage. Multiferroic materials ... to the coexistence of electric and magnetic orders. ... electric and magnetic polarizations is rare in known ... MEM effect. This article briefly reviews a new ...
Breaking Biology Technology:Bioptigen Introduces Deep Imaging OCT System for Contact Lens Metrology 2Applied Silicone Launches Silicone Gel System with Dual Matrix Technology 2Hydro Dynamics Partners with the Continuous Flow Chemistry Experts of Proteaf Technologies 2
... , , , M. Arun Kumar, PhD, and Vincent ... Brinkmann BioSystems Laboratory, , Abstract , ... plates, , we carried out PCR reactions with ... commercial microplate supplier and compared the reaction , ...
... Perfectprep , Gel Cleanup Kit , ... George Halley, Eppendorf 5 Prime, Inc., , , ... Agarose gel electrophoresis is used extensively to separate and analyze , ... Perfectprep Gel Cleanup kit is used to purify DNA fragments of ...
... , , , , , ... The new Ependorf Micromanipulator for electro-physiology, , ... (MPI) for Biophysical Chemistry in Gttingen (Germany)., , , ... , The Micromanipulator PatchMan was used at MPI for a ...
Cached Biology Technology:An Assessment of the Eppendorf twin.tec plate performance in PCR* , applications 2An Assessment of the Eppendorf twin.tec plate performance in PCR* , applications 3An Assessment of the Eppendorf twin.tec plate performance in PCR* , applications 4An Assessment of the Eppendorf twin.tec plate performance in PCR* , applications 5An Assessment of the Eppendorf twin.tec plate performance in PCR* , applications 6An Assessment of the Eppendorf twin.tec plate performance in PCR* , applications 7Restriction Digests of DNA Isolated with the Perfectprep , Gel Cleanup Kit 2Restriction Digests of DNA Isolated with the Perfectprep , Gel Cleanup Kit 3Restriction Digests of DNA Isolated with the Perfectprep , Gel Cleanup Kit 4Restriction Digests of DNA Isolated with the Perfectprep , Gel Cleanup Kit 5PatchMan - Test Report 2
Preparation Note: Prepared essentially by method of Singer, T.P., J. Biol. Chem., 174, 11 (1948). Quality Clarifier: Contains lipase Unit Definition: One unit will hydrolyze 1.0 μmole of p-ni...
... Phosphatase-2A (PPase-2A) is a serine/threonine phosphatase isolated ... isolated as the heterodimer of 60kDa (A) ... ability to dephosphorylate the a-subunit of phosphorylase ... has broad substrate specificity and may play ...
... Assays in Tris buffer, pH 10.2 give ... buffer system. Assays in diethanolamine buffer, pH ... the glycine buffer system. Protein determined by ... buffer salts Preparation Unit Definition: One unit ...
... ATP Monitoring Kit measures adenosine ... sensitivity and a dynamic range. ... the assay measures ATP in ... over a concentration range of ...
Biology Products: