Navigation Links
In the test tube, teams reconstruct a cancer cell's beginning
Date:11/21/2010

SAN ANTONIO, Texas (Nov. 21, 2010) What prompts normal cells to transform themselves into cancerous cells? Researchers from Texas institutions, including the UT Health Science Center San Antonio, have identified factors in the very first step of the process and reconstituted this first step in the test tube. The latter accomplishment was reported Sunday [Nov. 21] in the top-tier journal Nature Structural & Molecular Biology.

The DNA molecule the elegant, twin-stranded necklace of life in all cells gets broken and repaired all the time. Breaks are caused by the body's metabolic activities such as energy consumption and environmental factors such as exposure to ultraviolet light. Cancer results when the repair response is absent or deficient.

"DNA breaks are considered to be a major instigator of cancer cell development," said Sang Eun Lee, Ph.D., associate professor of molecular medicine at the UT Health Science Center San Antonio. "When a break is detected, signals are sent to cells that repair is needed."

The early initiating step of the break repair and signaling "has been quite elusive for some time because the factors were not known," Dr. Lee said. He was lead author of a paper published recently in EMBO Journal that identified a set of enzymes called Mre11 and Exo1.

In the Nature paper the researchers, who included the lab of Tanya Paull, Ph.D., at UT Austin, "repeated the process in a test tube because we now knew about Mre11 and Exo1," Dr. Lee said.


'/>"/>

Contact: Will Sansom
sansom@uthscsa.edu
210-567-2579
University of Texas Health Science Center at San Antonio
Source:Eurekalert

Page: 1

Related biology news :

1. White House Science Fair showcases Lemelson-MIT InvenTeams
2. Energy drinks may give young sports teams an edge, study says
3. LSU expert teams with Ohio State researcher to track species affected by Gulf oil spill
4. EPA awards more than $1 million to college teams for environmental innovation
5. CIC Teams with Docubase Systems to Deliver eSignature Enabled Document Management Solutions
6. The PTR Group Announces Financial and Technical Support to US FIRST Robotics Competition Teams
7. CIC Teams with Docubase Systems to Deliver eSignature Enabled Document Management Solutions
8. University of Houston diesel testing center teams with state transportation agency to cut emissions
9. ESAs Earth observation missions: Sharing teams and facilities boosts efficiency
10. Entomological Society of Americas Linnaean Games teams selected
11. CIC Teams With Industry Leader iPipeline to Provide Electronic Signature Platform to the Nations Top Insurance Carriers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2017)... and ITHACA, N.Y. , June ... Cornell University, a leader in dairy research, today announced ... designed to help reduce the chances that the global ... onset of this dairy project, Cornell University has become ... Sequencing the Food Supply Chain, a food safety initiative ...
(Date:5/23/2017)... 2017  Hunova, the first robotic gym for the rehabilitation and functional ... in Genoa, Italy . The first 30 robots will ... USA . The technology was developed and patented at ... IIT spin-off Movendo Technology thanks to a 10 million euro investment from ... click: ...
(Date:5/16/2017)... 16, 2017   Bridge Patient Portal , ... MD EMR Systems , an electronic medical ... GE, have established a partnership to build an ... the GE Centricity™ products, including Centricity Practice Solution ... These new integrations will allow healthcare delivery ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... ... solutions, today announced safety software company AB Cube has joined its ... segment to advance technology innovation across life sciences and healthcare. Under the ...
(Date:7/17/2017)... ... , ... Panitch Schwarze Belisario & Nadel intellectual ... Innovation Group) annual meeting in China. , This year’s meeting, held June 9-10 ... a rapidly developing highly personalized anti-cancer technology that involves removing some of a ...
(Date:7/16/2017)... ... July 16, 2017 , ... OHAUS Corporation, ... the launch of its new line of Rocking and Waving Shakers today. , ... models (both analog and digital) for laboratory applications in a variety of environmental ...
(Date:7/14/2017)... ... July 14, 2017 , ... Sonic Manufacturing Technologies is proud ... installed a solar system on its roof top. “We will be independent of ... Kenneth Raab stated. The company’s proud history of social responsibility and participation in ...
Breaking Biology Technology: