Navigation Links
In the laboratory, green tea proves a powerful medicine against severe sepsis
Date:11/8/2007

MANHASSET, NY A major component of green tea could prove the perfect elixir for severe sepsis, an abnormal immune system response to a bacterial infection. In a new laboratory study, Haichao Wang, PhD, of The Feinstein Institute for Medical Research, and his colleagues have been studying the therapeutic powers of dozens of Chinese herbal compounds in reversing a fatal immune response that kills 225,000 Americans every year. They found that an ingredient in green tea rescued mice from lethal sepsis and the findings could pave the way to clinical trials in patients.

The study was published this week in the Public Library of Science, or PLoS-ONE. Dr. Wang had previously discovered a late mediator of sepsis called HMGB1, a substance expressed in the late stages of lethal sepsis. They wanted to figure out a way to block this substance, which they felt would prevent the lethal sepsis process from moving forward. And it worked.

Scientists worldwide have been stumped by sepsis. Even with the most advanced medical techniques available, half of those who develop sepsis die of the massive assault on the body. Several laboratories at the Feinstein Institute are working on sepsis both on the basic biological level and in patients.

In the latest study, Dr. Wangs group gave a substance in green tea called EGCG to mice in the throes of severe sepsis. The dose was equivalent to 10 cups in a human. Survival jumped from 53 percent in those who didnt receive the green tea substance to 82 percent in those who did. Clinically, even if we could save five percent of patients, that would be huge, said Dr. Wang. In this study, we saved 25 percent more animals with the green tea. He said that the green tea component, EGCG, is readily available.

There have been more than 100 papers focusing on this natural substance and its anti-cancer benefits. This compound prevents HMGB1 from being released by immune cells and it also prevents it from activating immune cells to produce more cytokines, he said. Cytokines are produced by immune cells and act as weapons to defend the body against invaders. We are hoping to stimulate future interest in clinical studies, said Dr. Wang, who worked on the study in collaboration with Wei Li, PhD, Andrew Sama, MD, chairman of emergency medicine at North Shore University Hospital, and other Feinstein investigators.


'/>"/>

Contact: Jamie Talan
jtalan@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, September 2007
2. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2007
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. New study shows greenback cutthroat trout involved in recovery effort misidentified
5. American Chemical Society calls green chemistry bill a smart step
6. Salmon garnish points the way to green electronics
7. Using green chemistry to deliver cutting-edge drugs
8. Green skies: Engineers work may reduce jet travels role in global warming
9. A greenhouse in order to study the impact of climate change on plants
10. Green leather is in this season
11. Study involving more than 100 scientists provides new insights on green algae
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC ... today announced the opening of an IoT Center of ... strengthen and expand the development of embedded iris biometric ... unprecedented level of convenience and security with unmatched biometric ... one,s identity aside from DNA. EyeLock,s platform uses video ...
(Date:5/3/2016)... Lithuania , May 3, 2016  Neurotechnology, ... released the MegaMatcher Automated Biometric Identification System ... of large-scale multi-biometric projects. MegaMatcher ABIS can process ... accuracy using any combination of fingerprint, face or ... MegaMatcher SDK and MegaMatcher Accelerator ...
(Date:4/26/2016)... and LONDON , ... Finacle, part of EdgeVerve Systems, a product subsidiary ... Onegini today announced a partnership to integrate the ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... provide their customers enhanced security to access and ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... , ... June 23, 2016 , ... ... announced the launch of the Supplyframe Design Lab . Located in Pasadena, ... explore the future of how hardware projects are designed, built and brought to ...
(Date:6/23/2016)... BEACH, Calif. , June 23, 2016  Blueprint ... new biological discoveries to the medical community, has closed ... co-founder Matthew Nunez . "We have ... us with the capital we need to meet our ... will essentially provide us the runway to complete validation ...
(Date:6/23/2016)... ... June 23, 2016 , ... Regulatory Compliance Associates® ... provides a free webinar on Performing Quality Investigations: Getting to Root ... CT at no charge. , Incomplete investigations are still a major concern to ...
(Date:6/22/2016)... , June 22, 2016 Cell ... will allow them to produce up to one ... one lot within one week. These high-quality, consistent ... laboriously preparing cells and spend more time doing ... through a proprietary, high-volume manufacturing process that produces ...
Breaking Biology Technology: