Navigation Links
In the laboratory, green tea proves a powerful medicine against severe sepsis
Date:11/8/2007

MANHASSET, NY A major component of green tea could prove the perfect elixir for severe sepsis, an abnormal immune system response to a bacterial infection. In a new laboratory study, Haichao Wang, PhD, of The Feinstein Institute for Medical Research, and his colleagues have been studying the therapeutic powers of dozens of Chinese herbal compounds in reversing a fatal immune response that kills 225,000 Americans every year. They found that an ingredient in green tea rescued mice from lethal sepsis and the findings could pave the way to clinical trials in patients.

The study was published this week in the Public Library of Science, or PLoS-ONE. Dr. Wang had previously discovered a late mediator of sepsis called HMGB1, a substance expressed in the late stages of lethal sepsis. They wanted to figure out a way to block this substance, which they felt would prevent the lethal sepsis process from moving forward. And it worked.

Scientists worldwide have been stumped by sepsis. Even with the most advanced medical techniques available, half of those who develop sepsis die of the massive assault on the body. Several laboratories at the Feinstein Institute are working on sepsis both on the basic biological level and in patients.

In the latest study, Dr. Wangs group gave a substance in green tea called EGCG to mice in the throes of severe sepsis. The dose was equivalent to 10 cups in a human. Survival jumped from 53 percent in those who didnt receive the green tea substance to 82 percent in those who did. Clinically, even if we could save five percent of patients, that would be huge, said Dr. Wang. In this study, we saved 25 percent more animals with the green tea. He said that the green tea component, EGCG, is readily available.

There have been more than 100 papers focusing on this natural substance and its anti-cancer benefits. This compound prevents HMGB1 from being released by immune cells and it also prevents it from activati
'/>"/>

Contact: Jamie Talan
jtalan@nshs.edu
516-562-1232
North Shore-Long Island Jewish (LIJ) Health System
Source:Eurekalert

Page: 1 2

Related biology news :

1. Story tips from the US Department of Energys Oak Ridge National Laboratory, September 2007
2. Story tips from the Department of Energys Oak Ridge National Laboratory, October 2007
3. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
4. New study shows greenback cutthroat trout involved in recovery effort misidentified
5. American Chemical Society calls green chemistry bill a smart step
6. Salmon garnish points the way to green electronics
7. Using green chemistry to deliver cutting-edge drugs
8. Green skies: Engineers work may reduce jet travels role in global warming
9. A greenhouse in order to study the impact of climate change on plants
10. Green leather is in this season
11. Study involving more than 100 scientists provides new insights on green algae
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... , Nov. 4, 2014   Neurotechnology ... today announced that the latest version of its ... the Ongoing MINEX evaluation organized by ... fingerprint algorithms using the INCITS 378 fingerprint standard ... requirement in public tenders in the ...
(Date:11/3/2014)... Center study published in this month,s ... the activity of a recently discovered communication molecule of ... has been known to limit inflammation and the current ... IL-37 inhibits the ability of the immune system to ... that underlies IL-37,s effect on the immune system now ...
(Date:11/3/2014)... from Australia report that low birth weight and preterm ... hip replacements in adulthood. Findings published in the American ... Research , indicate that low birth weight and pre-term ... due to OA as adults. , According to ... 25 are diagnosed with clinical OA. Symptoms of OA ...
Breaking Biology News(10 mins):Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 2Neurotechnology Places Second in Ongoing MINEX Ranking for Fingerprint Matching Algorithms 3PNAS: From HIV to cancer, IL-37 regulates immune system 2Preterm, low birth-weight babies may need new hips in adulthood 2
... University of California, Davis have discovered that a prototype ... causes of heart failure. Heart failure, which ... the body, affects 5 million people in the United ... The research in the laboratories of cardiologist ...
... but is dangerous to your eyes and skin, says a ... absolutely no benefit over bleaching without UV, and damages skin ... reports a study in Photochemical & Photobiological Sciences . ... be better off ignoring claims of better bleaching with UV ...
... Texas AgriLife Research scientists, talk about their study which reveal antioxidant and phytonutrient properties in stone fruits, ... Click here for more information. ... , , , , ... , , ...
Cached Biology News:UC Davis research shows that newly discovered drug reduces heart enlargement 2Plums poised to give blueberries run for the money 2Plums poised to give blueberries run for the money 3Plums poised to give blueberries run for the money 4
(Date:11/26/2014)... 2014 Theravalues Corporation est fier d,annoncer ... européen au salon Hi Europe 2014 (du 2 ... Curcumine la plus biodisponible actuellement sur ... à des ingrédients approuvés par les règlements européens. ... présent dans la racine de curcuma ( Curcuma ...
(Date:11/26/2014)... 25 novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia con ... europeo in occasione di Hi Europe 2014 (dal 2 ... Si tratta della curcumina con la maggiore biodisponibilità ... cristalli) e ingredienti approvati dalle norme europee. ... della pianta curcumina ( Curcuma longa ) che è ...
(Date:11/24/2014)... -- IGI Laboratories, Inc. (NYSE MKT: IG), a ... today announced it has submitted an additional abbreviated new ... Administration (FDA), which brings the Company,s total number of ... now pending at the FDA. ... commented, "Our team here at IGI has continued to ...
(Date:11/24/2014)... Nov. 24, 2014  Last week, Representatives ... (D-NC) took a bold bipartisan step on ... the OPEN Act. Original co-sponsors of the legislation ... Act will incentivize drug makers and innovators to ... and pediatric cancers, which opens the door to ...
Breaking Biology Technology:La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 2La curcumine présentant la plus haute biodisponibilité bientôt en vente en Europe 3La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3IGI Laboratories, Inc. Announces ANDA Submission 2OPEN Act Introduced to Repurpose Drugs for Rare Diseases 2
... , , , ... ) announced that it will be hosting a conference call to discuss today,s ... begin at 8:30 a.m. Eastern Time (ET)/5:30 a.m. Pacific Time (PT). , ... accessed through a link that is posted on the home page of Nektar,s ...
... ... firms have to follow a rigorous documentation process to comply with a ... corporate agreements these firms are faced with the daunting task of sharing ... affordable unlimited use facility to share thousands of confidential documents securely and ...
... question, researchers with the U.S. Department of Energy,s ... that the selective placement of strain can alter ... correlated electron materials. This unique class of materials ... display properties such as colossal magnetoresistance and high-temperature ...
Cached Biology Technology:Nektar Therapeutics to Host Conference Call to Discuss Today's Announcement of a New Partnership for NKTR-118 and NKTR-119 2Life Science Firms are Turning to Firmex to do Deals Online 2Life Science Firms are Turning to Firmex to do Deals Online 3Strain on nanocrystals could yield colossal results 2Strain on nanocrystals could yield colossal results 3
Yellow oily liquid. Contains 85% Drakeol 5NF, 15% Arlacel A (mannide monooleate emulsifier). Heat sterilized. Contains zero colony forming units/ml. ...
... produces output at 470 nm; includes interface cable ... or installed into rack or desktop boxes ... is an LED that produces either pulsed or ... region -- for fluorescence measurements. The source is ...
... LNA microarray slides for microRNA expression ... incorporate Exiqons unique Locked Nucleic Acid (LNA) ... mismatch discrimination for short microRNA (miRNA) targets. ... 1 g total RNA (no need for ...
... Clear amber to slightly ... Contains 10 vials per set, each ... adjuvant homogenized in the following proportions ... Arlacel A (mannide monooleate emulsifier), and ...
Biology Products: