Navigation Links
In the lab, engineer's novel liquid provides a solid fix for broken bones
Date:12/7/2010

Here's the vision: an elderly woman comes into the emergency room after a fall. She has broken her hip. The orthopaedic surgeon doesn't come with metal plates or screws or shiny titanium ball joints. Instead, she pulls out a syringe filled with a new kind of liquid that will solidify in seconds and injects into the break. Over time, new bone tissue will take its place, encouraged by natural growth factors embedded in the synthetic molecules of the material.

Although still early in its development, the liquid is real. In the Brown engineering lab of professor Thomas Webster it's called TBL, for the novel DNA-like "twin-base linker" molecules that give it seemingly ideal properties. The biotech company Audax Medical Inc., based in Littleton, Mass., announced on Dec. 7 an exclusive license of the technology from Brown. It brands the technology as Arxis and sees similar potential for repairing broken vertebrae.

"The reason we're excited about this material is because it gets us away from metals," Webster said. "Metals are not in us naturally and they can have a lot of problems with surrounding tissues."

In some of his work, Webster employs nanotechnology to try to bridge metals to bone better than traditional bone cement. But TBL is an entirely new material, co-developed with longtime colleague and chemist Hicham Fenniri at the University of Alberta. Fenniri synthesized the molecules, while Webster's research has focused on ensuring that TBL becomes viable material for medical use.

The molecules are artificial, but made from elements that are no strangers to the body: carbon, nitrogen, and oxygen. At room temperature their aggregate form is a liquid, but the material they form solidifies at body temperature. The molecules look like nanoscale tubes (billionths of a meter wide), and when they come together, it is in a spiraling ladder-shaped arrangement reminiscent of DNA or collagen. That natural structure makes it easy to integra
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert

Page: 1 2

Related biology news :

1. UC San Diego bioengineers fill holes in science of cellular self-organization
2. Caltech engineers build firast-ever multi-input plug-and-play synthetic RNA device
3. Biomedical engineers detective work reveals antibiotic mechanism
4. Engineers create intelligent molecules that seek-and-destroy diseased cells
5. Iowa student engineers develop hand-held water sanitizer for a thirsty world
6. Ben-Gurion University engineers develop technique to help combat nuclear proliferation
7. LabRoots Launches Social Networking Site for Scientists & Engineers
8. Engineers develop method to disperse chemically modified graphene in organic solvents
9. Case Western Reserve University engineers hit pay dirt with clay mixture
10. New method developed by UC San Diego bioengineers gives regenerative medicine a boost
11. Vanderbilt engineers play key role in new DOE energy frontier research center
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... -- Curemark LLC, a privately held drug research and ... III double blind, randomized, placebo-controlled clinical trial to examine ... children ages 3-8 with Autism. Previously, Curemark announced the ... clinical trial for CM-AT in children ages 3-8 with ... chymotrypsin. This new trial will help determine whether all ...
(Date:5/8/2015)... -- Synaptics Inc. (NASDAQ: SYNA ), the leading developer ... executive management team will present at the following investor events: ... Conference Date: May 18, 2015 Time: 10:40am ET ... Cowen and Company Technology, Media & Telecom ... New York Palace Hotel, New York, NY ...
(Date:5/6/2015)... AVIV, Israel , May 6, 2015 ... world,s most established helmet producer, announced today that they ... Smart Helmet, the world,s first bio-sensing cycling helmet and ... be released in two new colors in order to ... for the product. In addition, LifeBEAM and Lazer announced ...
Breaking Biology News(10 mins):Curemark, LLC, Launches New Phase III Trial in Expanded Population of Children with Autism 2Synaptics to Present at Upcoming Investor Conferences 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3
... Girls are hitting puberty earlier and earlier. One recent study ... some breast development by age 7. This news has upset ... cases for girls to develop faster, according to the authors ... a journal of the Association for Psychological Science. ...
... Here,s good news for anyone trying to lose weight or ... a weight loss drug that may revolutionize how we treat ... the September 2010 print issue of The FASEB Journal ... responsible for regulating body fat and bone mass. Then they ...
... that anchors itself to the sea bed, offers new clues ... Sheet a region that is thought to be vulnerable ... the Census of Antarctic Marine Life (CAML), scientists from British ... and deep sea regions around the continent and from further ...
Cached Biology News:Girls' early puberty linked to unstable environment via insecure attachment in infancy 2Scientists discover new protein that gets to the roots of obesity and osteoporosis 2Marine animals suggest evidence for a trans-Antarctic seaway 2
(Date:5/27/2015)...  Tikcro Technologies Ltd. (OTCQB: TIKRF) today reported results ... Aviv Boim , CEO of Tikcro ... generate functional specific antibodies, targeting identified cancer immune checkpoints. ... by the development progress. We are excited to invest ... immune checkpoints gain clinical acceptance for cancer treatment."Net loss ...
(Date:5/27/2015)... BETHESDA, Md. , May 27, 2015  Northwest ... biotechnology company developing DCVax® personalized immune therapies for cancer, ... Chief Technical Officer of the Company, will be making ... Annual Meeting in Chicago on ... CDT, at the Industry Expert Theater in McCormick Place. ...
(Date:5/27/2015)... 2015  RXi Pharmaceuticals Corporation (NASDAQ: RXII ... developing innovative therapies primarily in the areas of ... status of the Company,s Series A and Series ... http://photos.prnewswire.com/prnh/20130917/NE80755LOGO At March ... of Series A Preferred Stock and Series A-1 ...
(Date:5/26/2015)... Regenestem Network has announced the grand opening ... Argentina. The clinic will be lead by Silvina Pastrana, ... a multidisciplinary team of medical professionals who specialize in ... office. , The new Regenestem Network members plan ... in cellular therapies, and establish Regenestem protocols to isolate ...
Breaking Biology Technology:Tikcro Technologies Reports First Quarter 2015 Results 2Tikcro Technologies Reports First Quarter 2015 Results 3NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 2NW Bio To Present Overview Of DCVax-Direct Phase I Trial In Chicago This Weekend 3RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 2RXi Pharmaceuticals Provides an Update on Series A and Series A-1 Preferred Stock 3Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 2Regenestem Network and Silvina Pastrana, M.D. Announce the Opening of a New Stem Cell Clinic in Buenos Aires 3
... Newly proposed Medicare rules designed to promote ... closely mirror quality reporting programs already well established ... MedeAnalytics analysis has found. (Logo: ... analysis is included in MedeAnalytics, white paper, "Accountable ...
... 4, 2011 Omeros Corporation (NASDAQ: OMER ... commercializing products focused on inflammation, bleeding and disorders of ... Demopulos, M.D., chairman and chief executive officer, is scheduled ... taking place in New York City this week.  The ...
... Techne Corporation (NASDAQ: TECH ) ... its R&D Systems subsidiary has acquired the assets ... manufacturer of innovative ubiquitin-related research products.  These products ... accelerate basic research and drug discovery efforts.  R&D ...
Cached Biology Technology:ACO Proposed Rule: Nine out of Ten Quality Measures Mirror Other Quality Reporting Programs 2Techne Corporation Announces Acquisition 2Techne Corporation Announces Acquisition 3Techne Corporation Announces Acquisition 4
...
Coverslips for Microarrays, 1. *Category: MICROARRAY ACCESSORIES....
S. O'Hare & C.K. Atterwill • In vitro toxicity techniques for regular lab use. Ex vivo techniques are also covered with the aim of reducing and refining the use of animals in the future....
... Cap 0 (or Cap 0-like) RNA into ... has been shown to increase in vivo ... improvement is seen in Cap 0 structures ... as well as those Cap 0 structures ...
Biology Products: