Navigation Links
In scientific first, researchers visualize naturally occurring mRNA
Date:1/16/2011

January 16, 2011 (BRONX, NY) In a technique that could eventually shed light on how gene expression influences human disease, scientists at Albert Einstein College of Medicine of Yeshiva University have for the first time ever successfully visualized single molecules of naturally-occurring messenger RNA (mRNA) transcribed in living mammalian cells. The scientific achievement is detailed in the January 16 online edition of Nature Methods.

Gene expression involves transcribing a gene's DNA into molecules of mRNA. These molecules then migrate from a cell's nucleus into the cytoplasm, where they serve as blueprints for protein construction.

Robert Singer, Ph.D., codirector of the Gruss Lipper Biophotonics Center and professor and cochair of anatomy and structural biology, was senior author of the paper. Working with his colleagues, he generated a transgenic mouse in which genes coding for the structural protein beta actin would, when expressed, yield fluorescently labeled mRNA. Beta actin mRNA is a highly expressed molecule found in all mammalian tissues.

The technique used by the Einstein researchers should be applicable for monitoring the expression of any gene of interest. Prior to this study, Einstein researchers had monitored mRNA molecules transcribed by artificial genes.

"Our report is the first demonstration that our technique can be used to visualize the expression of an essential gene in mammalian cells," said Timothe Lionnet, Ph.D., a research fellow in Dr. Singer's lab and lead author of the Nature Methods paper. "We can study beta actin RNA molecules over their life cycle in a variety of cell types and discover where they are distributed within the cell. This has important consequences for human disease like cancer, since the way molecules of mRNA are localized within tumor cells correlates with the ability of these cells to spread, or metastasize."


'/>"/>

Contact: Kim Newman
sciencenews@einstein.yu.edu
718-430-3101
Albert Einstein College of Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. College students lack scientific literacy, study finds
2. Epilepsy researcher at the Childrens Hospital of Philadelphia receives scientific prize
3. Elsevier offers scientific book content through Google eBooks
4. Argonne scientists awarded supercomputing time to enable scientific breakthroughs
5. Scientific Grand Challenges identified to address global sustainability
6. Missouri Botanical Garden joins convention on biological diversity consortium of scientific partners
7. Science never seen before is focus of first scientific conference on gigapixel imaging
8. Falling in love more scientific than you think, according to Syracuse University professor
9. Entire issue of scientific journal devoted to center headed by Scripps Research Scientists
10. Snap of fruit fly embryo wins scientific photo competition
11. International scientific forum on alcohol research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/13/2017)... SANTA MONICA, Calif. , April 13, 2017 /PRNewswire/ ... New York will feature emerging and ... Innovation Summits. Both Innovation Summits will run alongside the ... variety of speaker sessions, panels and demonstrations focused on ... east coast,s largest advanced design and manufacturing event will ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
(Date:4/11/2017)... BROOKLYN, N.Y. , April 11, 2017 /PRNewswire-USNewswire/ ... identical fingerprints, but researchers at the New York ... University College of Engineering have found that partial ... fingerprint-based security systems used in mobile phones and ... previously thought. The vulnerability lies in ...
Breaking Biology News(10 mins):
(Date:10/10/2017)... ... , ... Dr. Bob Harman, founder and CEO of VetStem Biopharma, Inc. ... The event entitled “Stem Cells and Their Regenerative Powers,” was held on August ... MPVM was joined by two human doctors: Peter B. Hanson, M.D., Chief of Orthopedic ...
(Date:10/10/2017)... ... October 10, 2017 , ... ... optimization firm for the life sciences and healthcare industries, announces a presentation by ... Francisco. , The presentation, “Automating GxP Validation for Agile Cloud Platforms,” will present ...
(Date:10/9/2017)... ... October 09, 2017 , ... The award-winning American Farmer television ... quarter 2018. American Farmer airs Tuesdays at 8:30aET on RFD-TV. , With global ... the challenge of how to continue to feed a growing nation. At the same ...
(Date:10/9/2017)... ... October 09, 2017 , ... ... 2017, in the medical journal, Epilepsia, Brain Sentinel’s SPEAC® System which uses ... EEG, in detecting generalized tonic-clonic seizures (GTCS) using surface electromyography (sEMG). The ...
Breaking Biology Technology: