Navigation Links
In scientific first, researchers visualize naturally occurring mRNA

January 16, 2011 (BRONX, NY) In a technique that could eventually shed light on how gene expression influences human disease, scientists at Albert Einstein College of Medicine of Yeshiva University have for the first time ever successfully visualized single molecules of naturally-occurring messenger RNA (mRNA) transcribed in living mammalian cells. The scientific achievement is detailed in the January 16 online edition of Nature Methods.

Gene expression involves transcribing a gene's DNA into molecules of mRNA. These molecules then migrate from a cell's nucleus into the cytoplasm, where they serve as blueprints for protein construction.

Robert Singer, Ph.D., codirector of the Gruss Lipper Biophotonics Center and professor and cochair of anatomy and structural biology, was senior author of the paper. Working with his colleagues, he generated a transgenic mouse in which genes coding for the structural protein beta actin would, when expressed, yield fluorescently labeled mRNA. Beta actin mRNA is a highly expressed molecule found in all mammalian tissues.

The technique used by the Einstein researchers should be applicable for monitoring the expression of any gene of interest. Prior to this study, Einstein researchers had monitored mRNA molecules transcribed by artificial genes.

"Our report is the first demonstration that our technique can be used to visualize the expression of an essential gene in mammalian cells," said Timothe Lionnet, Ph.D., a research fellow in Dr. Singer's lab and lead author of the Nature Methods paper. "We can study beta actin RNA molecules over their life cycle in a variety of cell types and discover where they are distributed within the cell. This has important consequences for human disease like cancer, since the way molecules of mRNA are localized within tumor cells correlates with the ability of these cells to spread, or metastasize."


Contact: Kim Newman
Albert Einstein College of Medicine

Page: 1

Related biology news :

1. College students lack scientific literacy, study finds
2. Epilepsy researcher at the Childrens Hospital of Philadelphia receives scientific prize
3. Elsevier offers scientific book content through Google eBooks
4. Argonne scientists awarded supercomputing time to enable scientific breakthroughs
5. Scientific Grand Challenges identified to address global sustainability
6. Missouri Botanical Garden joins convention on biological diversity consortium of scientific partners
7. Science never seen before is focus of first scientific conference on gigapixel imaging
8. Falling in love more scientific than you think, according to Syracuse University professor
9. Entire issue of scientific journal devoted to center headed by Scripps Research Scientists
10. Snap of fruit fly embryo wins scientific photo competition
11. International scientific forum on alcohol research
Post Your Comments:
(Date:6/22/2016)... 22, 2016   Acuant , the ... solutions, has partnered with RightCrowd ® ... Visitor Management, Self-Service Kiosks and Continuous Workforce ... add functional enhancements to existing physical access ... venues with an automated ID verification and ...
(Date:6/16/2016)... June 16, 2016 The ... expected to reach USD 1.83 billion by 2024, ... Research, Inc. Technological proliferation and increasing demand in ... expected to drive the market growth. ... The development of advanced multimodal techniques for ...
(Date:6/7/2016)... 7, 2016  Syngrafii Inc. and San Antonio ... that includes integrating Syngrafii,s patented LongPen™ eSignature "Wet" ... collaboration will result in greater convenience for SACU ... while maintaining existing document workflow and compliance requirements. ... Highlights: ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... DIEGO , June 27, 2016  Sequenom, Inc. ... committed to enabling healthier lives through the development of ... Court of the United States ... courts that the claims of Sequenom,s U.S. Patent No. ... patent eligibility criteria established by the Supreme Court,s Mayo ...
(Date:6/27/2016)... 2016  Liquid Biotech USA ... a Sponsored Research Agreement with The University of ... from cancer patients.  The funding will be used ... with clinical outcomes in cancer patients undergoing a ... be employed to support the design of a ...
(Date:6/24/2016)... ... , ... Researchers at the Universita Politecnica delle Marche in Ancona combed medical ... mesothelioma. Their findings are the subject of a new article on the Surviving Mesothelioma ... in the blood, lung fluid or tissue of mesothelioma patients that can help point ...
(Date:6/23/2016)... , June 23, 2016 A person commits ... the crime scene to track the criminal down. ... U.S. Food and Drug Administration (FDA) uses DNA evidence to ... Sound far-fetched? It,s not. The FDA has ... to support investigations of foodborne illnesses. Put as simply as ...
Breaking Biology Technology: