Navigation Links
In schizophrenia research, a path to the brain through the nose
Date:1/25/2012

Philadelphia, PA, January 25, 2012 A significant obstacle to progress in understanding psychiatric disorders is the difficulty in obtaining living brain tissue for study so that disease processes can be studied directly. Recent advances in basic cellular neuroscience now suggest that, for some purposes, cultured neural stem cells may be studied in order to research psychiatric disease mechanisms. But where can one obtain these cells outside of the brain?

Increasingly, schizophrenia research is turning to the nose. Strange as it may seem, the idea makes sense because the olfactory mucosa, the sense organ of smell in the nose, is continually regenerating new sensory neurons from "adult" stem cells. These neurons are among the very few nerve cells outside of the skull that connect directly to nerve cells in the brain.

Over several decades, researchers found that these cells can be collected directly by obtaining a small tissue sample, called a biopsy. By taking small pieces of olfactory tissue from the nose, researchers of this new study were able to gain access to the stem cells from patients with schizophrenia and compare them to cells from healthy individuals.

"We have discovered that patient cells proliferate faster - they are running with a faster speed to their clock controlling the cell cycle - and we have identified some of the molecules that are responsible," explained Dr. Alan Mackay-Sim from the National Centre for Adult Stem Cell Research in Brisbane, Australia, an author of the study. The findings clearly indicate that the natural cell cycle is dysregulated in individuals diagnosed with schizophrenia.

"This is a first insight into real differences in patient cells that could lead to slightly altered brain development," Mackay-Sim added. This is an important finding, as scientists are already aware of many developmental abnormalities in the 'schizophrenia brain'.

Dr. John Krystal, editor of Biological
'/>"/>

Contact: Rhiannon Bugno
biol.psych@utsouthwestern.edu
214-648-0880
Elsevier
Source:Eurekalert

Page: 1 2

Related biology news :

1. Brain-nourishing molecule may predict schizophrenia relapse
2. MU brain imaging center provides research for autism, schizophrenia and Parkinsons disease
3. Pitt research identifies new target in brain for treating schizophrenia
4. Interaction between gene variants may alter brain function in schizophrenia
5. Research supports toxoplasmosis link to schizophrenia
6. Daily consumption of cannabis predisposes to the appearance of psychosis and schizophrenia
7. Researchers discover link between schizophrenia and diabetes
8. Altered gene can increase risk of schizophrenia
9. Flow of potassium into cells implicated in schizophrenia
10. LSUHSC research helps link schizophrenia to specific DNA region
11. A genetic basis for schizophrenia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/12/2014)... Fla. , Nov. 12, 2014 Crossmatch™, ... today that its U.are.U ® fingerprint readers have ... chain in Central Mexico . The ... 2014 to eliminate payroll issues caused by employees clocking ... installing the U.are.U fingerprint readers, Montparnasse relied on paper ...
(Date:11/7/2014)... -- Leading Biometric companies aim to provide consumers ... transactions.  Companies in focus today are: NXT-ID, Inc. (NASDAQ: ... ), Google Inc. (NASDAQ: GOOG ), Microsoft Corporation ... EBAY ) and MasterCard Inc. (NYSE: MA) NXT-ID, ... authentication company focused on the growing mobile commerce is pleased ...
(Date:11/5/2014)... of biology in the UTSA College of Sciences, ... selected to receive a two-year $300,00 National Science ... (EAGER). The funding supports President Obama,s BRAIN Initiative, ... new technology that will demystify complex brain processes. ... neuroscience are broken into the interactions of multiple ...
Breaking Biology News(10 mins):Montparnasse Pasteleria Achieves Time and Attendance Transparency with Crossmatch U.are.U Fingerprint Readers 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 2Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 3Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 4Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 5Universal Authentication Methods Provide More Secure Operations for Biometrics Devices - Company Joins FIDO Alliance for Consumer Protection 6UTSA biology professor awarded $300,000 NSF grant for brain research 2UTSA biology professor awarded $300,000 NSF grant for brain research 3
... A chance find by a high school student ... skeleton yet known from the iconic tube-crested dinosaur ... M. Alf Museum of Paleontology at The Webb Schools, ... before it celebrated its first birthday. Three-dimensional scans of ...
... Nitrogen fertilizer applied to crops lingers in the soil and ... longer than previously thought," scientists in France and at the ... years after synthetic nitrogen (N) fertilizer had been applied to ... N still remained in soil organic matter, the scientists found. ...
... In a new study published online in the journal ... that by swapping a single amino acid they could change ... on the surface of cells. The BK polyomavirus lost the ... the same sugar as its cousin SV40 polyomavirus, which is ...
Cached Biology News:High school student discovers skeleton of baby dinosaur 2High school student discovers skeleton of baby dinosaur 3Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find 2Nitrogen fertilizer remains in soils and leaks towards groundwater for decades, researchers find 3Single mutation gives virus new target 2
(Date:11/26/2014)... November 25, 2014 Whitehouse Laboratories ... joined the Morris County (New Jersey) Chamber of ... a leading business organization in the North Jersey ... further engage some key clients in the pharmaceutical ... the geographic area. Membership enables Whitehouse Laboratories a ...
(Date:11/26/2014)... (PRWEB) November 25, 2014 The Pittcon ... its official conference and exposition mobile app, ... free download in the App Store for iOS and ... valuable resource tool before, during and after the event. ... details on exhibiting companies, technical sessions, Conferee Networking sessions ...
(Date:11/26/2014)... N.J. and WILMINGTON, DE (PRWEB) November 26, 2014 ... 2nd Annual MPN Heroes recognition reception on December 5, ... of Hematology’s annual meeting. The MPN Heroes event will ... contributions in the field of myeloproliferative neoplasms (MPNs). ... show "Nashville," will discuss his family's cancer journey at ...
(Date:11/26/2014)... novembre 2014 /PRNewswrie/ -- Theravalues Corporation annuncia con orgoglio ... in occasione di Hi Europe 2014 (dal 2 al ... Si tratta della curcumina con la maggiore biodisponibilità di ... e ingredienti approvati dalle norme europee. La ... pianta curcumina ( Curcuma longa ) che è stata ...
Breaking Biology Technology:Whitehouse Laboratories Joins Morris County Chamber of Commerce 2Whitehouse Laboratories Joins Morris County Chamber of Commerce 3Pittcon Releases 2015 Mobile App 2CURE Magazine and Incyte to Honor MPN Heroes 2CURE Magazine and Incyte to Honor MPN Heroes 3CURE Magazine and Incyte to Honor MPN Heroes 4La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 2La curcumina con la maggiore biodisponibilità di sempre farà il suo debutto in Europa 3
... HARBIN, China, April 15 /PRNewswire-Asia-FirstCall/ -- China Sky One,Medical, ... CSKI ), a,leading fully integrated pharmaceutical company ... today announced record,financial results for the fourth quarter and ... Fourth Quarter 2008 Highlights, -- ...
... Inc. (Nasdaq: VTIV ) today announced that it ... conference call on Friday, May 8, 2009 at 8:30 a.m. ... listen, please dial 800-358-8448 (Domestic) or (706) 634-1367 (International). The ... at http://www.inventivhealth.com/about_us/n_webcasts.aspx . To listen, ...
... OmniComm Systems, Inc. (OTC Bulletin Board: OMCM) announced that ... LLC for the purpose of resolving the patent infringement ... entered into a licensing arrangement with DataSci. OmniComm ... have come to an agreement in this matter. ...
Cached Biology Technology:China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 2China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 3China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 4China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 5China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 6China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 7China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 8China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 9China Sky One Medical, Inc. Announces Record Fourth Quarter and Fiscal Year 2008 Results 10inVentiv Health to Announce First Quarter 2009 Results and Conduct Conference Call on Friday, May 8 2OmniComm Systems Announces Settlement of Patent Litigation With DataSci, LLC 2
...
... is a genetically engineered Klenow polymerase in which ... removed, leaving only the 5 to 3 polymerase ... Klenow Fragment the enzyme of choice for isotopic ... random primed method, and for DNA sequencing by ...
Request Info...
supplied with 10x reaction buffer...
Biology Products: