Navigation Links
In protein folding, internal friction may play a more significant role than previously thought
Date:4/24/2012

(Santa Barbara, Calif.) An international team of researchers has reported a new understanding of a little-known process that happens in virtually every cell of our bodies.

Protein folding is the process by which not-yet folded chains of amino acids assume their specific shapes, hence taking on their specific functions. These functions vary widely: In the human body, proteins fold to become muscles, hormones, enzymes, and various other components.

"This protein folding process is still a big mystery," said UC Santa Barbara physicist Everett Lipman, one of several authors of a paper, "Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy." The paper was published in the Proceedings of the National Academy of Sciences.

A protein's final shape, said Lipman, is primarily determined by the sequence of amino acid components in the unfolded chain. In the process, the components bump up against each other, and when the right configuration is achieved, the chain passes through its "transition state" and snaps into place.

"What we would like to understand eventually is how the chemical sequence of a protein determines what it is going to become and how fast it is going to get there," Lipman said.

Using a microfluidic mixing technique pioneered in the UCSB physics department by former graduate student Shawn Pfeil, the research team, including collaborators from the University of Zurich and the University of Texas, was able to monitor extremely rapid reconfiguration of individual protein molecules as they folded.

In the microfluidic mixer, a "denaturant" chemical used to unravel the proteins was quickly diluted, enabling observation of folding under previously inaccessible natural conditions. The measurements demonstrated that internal friction plays a more significant role in the folding process than could be seen in prior experiments, especially when t
'/>"/>

Contact: Sonia Fernandez
sonia.fernandez@ia.ucsb.edu
805-893-4765
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. Dont forget the vitamin A when working with its carrier protein
4. Saliva proteins could help detection of oral cancer
5. The structure of the Mre11 protein bound to DNA
6. New lab manual focuses on essential methods for purifying and characterizing proteins
7. Proteins in sperm unlock understanding of male infertility says new study
8. Response to immune protein determines pathology of multiple sclerosis
9. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
10. Human protein atlas will help pinpoint disease
11. How neuronal activity leads to Alzheimers protein cleavage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
In protein folding, internal friction may play a more significant role than previously thought
(Date:7/31/2015)... China , 31 de julho de 2015 /PRNewswire/ ... (ICG-10, www.icg-10.org ) será realizada pela BGI de 22-25 ... . A conferência está celebrando seu ... em 2006, a ICG se tornou uma das reuniões ... um dos encontros científicos mais dinâmicos, entusiastas e prazerosos. ...
(Date:7/31/2015)... La 10 th International Conference on Genomics ... 22 al 25 de octubre de 2015 en ... conferencia celebra su décimo aniversario. Desde su inauguración en el ... reuniones anuales más influyentes del mundo en el campo ,ómico, ... y mejores a nivel científico. ICG-10 se ...
(Date:7/31/2015)... 2015 NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market and creator of the ... patent 62/198989 for ELECTRONIC CRYPTO-CURRENCY MANAGEMENT METHOD ... to advance crypto-currencies such as Bitcoin into the consumer ... way to manage all payments.  The ...
Breaking Biology News(10 mins):A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 2A 10a. Conferência Internacional sobre Genômica (ICG-10) será em outubro 3La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3NXT-ID Patents Electronic Crypto-Currency Management Technology 2NXT-ID Patents Electronic Crypto-Currency Management Technology 3NXT-ID Patents Electronic Crypto-Currency Management Technology 4
... German . Aggressive male mating behavior might ... it can drive the species to extinction, an international research ... of Zurich has demonstrated in a mathematical model. ... of the individual is able to influence processes on a ...
... Most degenerative diseases begin with a gradual loss ... For example, in type I diabetes, hyperglycemia commonly develops when ... are lost; in Parkinson,s disease, motor dysfunction typically begins when ... by 70 to 80 percent. Finding ways to stop early ...
... Computer games are not just for kids. New research published ... Central open access journal, shows that computer games can speed ... stroke. It is often difficult for stroke victims to ... have problems six months later. Scientists in America looked at ...
Cached Biology News:Aggressive male mating behavior can endanger species 2New mouse model may lead to new therapies for degenerative diseases 2
(Date:8/27/2015)... Aug. 27, 2015  Neogen Corporation (NASDAQ: NEOG ... of United Kingdom -based Lab M ... media and diagnostic systems. Lab M ... leading provider of microbial testing and diagnostic products for ... The company currently sells into more than 70 countries ...
(Date:8/27/2015)... Aug. 27, 2015 The National Necrotizing ... eyes—and life—were saved by doctors at Vanderbilt University Hospital ... NNFF, NovaBay Pharmaceuticals and Dr. John Crew , ... at Seton Medical Center in Daly City, ... a breakthrough approach, pioneered by Dr. Crew, that had ...
(Date:8/27/2015)... - BIOREM Inc. (TSXV: BRM) ("Biorem" or "the Company") today announced ... 2015. Biorem,s complete second quarter financial statements and MD&A have been ... except earnings per shareThree-months ended , Six -months endedJune 30 , ... , 2014 Revenue , 4,709 , ... , 1,656 , 56 , 3,188 ...
(Date:8/27/2015)... 27, 2015 GlassesOff (OTCBB: GLSO), a ... in the human vision system, announced today a partnership with ... Chris Paul to develop a new mobile app ... improve their real-life on-court performance. Vision is the ... is shooting a ball or blocking a pass. The critical ...
Breaking Biology Technology:Neogen acquires U.K.-based Lab M Holdings 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 2Patient's Life and Eyes Saved from Gruesome Flesh-Eating Infection Consuming Her Face 3BIOREM Reports $718,000 Net Earnings for the Second Quarter 2BIOREM Reports $718,000 Net Earnings for the Second Quarter 3Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 2Eight-Time All-Star Chris Paul and GlassesOff Partner to Develop Innovative Mobile App Designed to Improve On-Court Performance 3
... adison, Wis. - Recently, as I sat at ... I couldn't help but reflect on how our professional lives ... better. , ,As the CEO of a company that ... knowledge, I remain impressed with how quickly technological change continues ...
... Madison, Wis. - Wisconsin-based high-tech startup and ... far-flung investors. The most recent example of this ... that is developing laboratory tools for analysis of ... of protein targets, quantitative microarrays, and related products, ...
... The exodus continues at Merge Technologies, Inc. , ... Merge Healthcare, has announced that it received "a written notification ... co-CEO, and president of Merge subsidiary Cedara Software , ... Aug. 18. , ,Pedlar is the fifth executive to leave ...
Cached Biology Technology:Visions: Rimas Buinevicius, CEO of Sonic Foundry 2Visions: Rimas Buinevicius, CEO of Sonic Foundry 3Wisconsin start up Primorigen Biosciences corrals out-of-state investment 2Pedlar the latest executive to leave Merge 2
High voltage electrophoresis power supply...
The Programmable MP-5000P-F Power Supply can be applied for any Microfluidic application....
...
Handy 100V Power Supply is Low-cost, compact and lightweight. Easy to operate - either 50 or 100 VDC is selectable as the output voltage. These voltages are sufficient for ordinary electrophoresis....
Biology Products: