Navigation Links
In protein folding, internal friction may play a more significant role than previously thought
Date:4/24/2012

(Santa Barbara, Calif.) An international team of researchers has reported a new understanding of a little-known process that happens in virtually every cell of our bodies.

Protein folding is the process by which not-yet folded chains of amino acids assume their specific shapes, hence taking on their specific functions. These functions vary widely: In the human body, proteins fold to become muscles, hormones, enzymes, and various other components.

"This protein folding process is still a big mystery," said UC Santa Barbara physicist Everett Lipman, one of several authors of a paper, "Quantifying internal friction in unfolded and intrinsically disordered proteins with single-molecule spectroscopy." The paper was published in the Proceedings of the National Academy of Sciences.

A protein's final shape, said Lipman, is primarily determined by the sequence of amino acid components in the unfolded chain. In the process, the components bump up against each other, and when the right configuration is achieved, the chain passes through its "transition state" and snaps into place.

"What we would like to understand eventually is how the chemical sequence of a protein determines what it is going to become and how fast it is going to get there," Lipman said.

Using a microfluidic mixing technique pioneered in the UCSB physics department by former graduate student Shawn Pfeil, the research team, including collaborators from the University of Zurich and the University of Texas, was able to monitor extremely rapid reconfiguration of individual protein molecules as they folded.

In the microfluidic mixer, a "denaturant" chemical used to unravel the proteins was quickly diluted, enabling observation of folding under previously inaccessible natural conditions. The measurements demonstrated that internal friction plays a more significant role in the folding process than could be seen in prior experiments, especially when t
'/>"/>

Contact: Sonia Fernandez
sonia.fernandez@ia.ucsb.edu
805-893-4765
University of California - Santa Barbara
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Photonic crystal biosensors detect protein-DNA interactions
2. Penn biophysicists create new model for protein-cholesterol interactions in brain and muscle tissue
3. Dont forget the vitamin A when working with its carrier protein
4. Saliva proteins could help detection of oral cancer
5. The structure of the Mre11 protein bound to DNA
6. New lab manual focuses on essential methods for purifying and characterizing proteins
7. Proteins in sperm unlock understanding of male infertility says new study
8. Response to immune protein determines pathology of multiple sclerosis
9. Columbia to award 2008 Horwitz Prize to Arthur Horwich & Ulrich Hartl for cellular protein folding
10. Human protein atlas will help pinpoint disease
11. How neuronal activity leads to Alzheimers protein cleavage
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
In protein folding, internal friction may play a more significant role than previously thought
(Date:7/10/2014)... the main organization of the International Science and Business ... group of researchers, led by professor Won Do Heo, ... optogenetics that can remotely control specific receptors by light. ... has succeeded with neuronal differentiation inducement. , The most ... only light to activate neuronal functions without the need ...
(Date:7/10/2014)... vegetable oil found in your popcorn or soap might not ... even worse, according to an analysis in the Cell Press ... growing demand for vegetable oil has already led to the ... trouble for orangutans in particular. If guidelines are not put ... large-scale industrial plantations from Asia into Africa will be bad ...
(Date:7/10/2014)... the open ocean as a microbial megacity, teeming with ... of water, hundreds of types of bacteria can be ... these ocean microbes have their own daily cyclesnot unlike ... wake up, commute, work, and eat at the same ... Light-loving photoautotrophsbacteria that need solar energy to help them ...
Breaking Biology News(10 mins):New optogenetic tool for controlling neuronal signalling by blue light 2Hunger for vegetable oil means trouble for Africa's great apes 2New research finds ocean's most abundant organisms have clear daily cycles 2New research finds ocean's most abundant organisms have clear daily cycles 3
... Science Translational Medicine announces the addition of twelve ... as Associate Scientific Advisors for the journal. Starting mid-January, ... and consult with Science Translational Medicine editors ... "The Science Translational Medicine editors selected these ...
... spend billions of dollars each year on exotic smelling perfumes ... according to a new study in Psychological Science , ... natural" may be the best way to capture a potential ... animal mating habits: Animal studies have shown that male testosterone ...
... Neuroscience Programme at the IGC, has become one of ... competitive European Research Council grants, to the value of ... This grant, which recognises Mainen,s contribution to the Neuroscience ... of the neurotransmitter serotonin. The ERC is the most ...
Cached Biology News:Science Translational Medicine adds 12 new associate scientific advisors 2
(Date:7/10/2014)... upside down forever. Nanophysics makes sure of that. Mechanics researchers ... published in Physical Review E . Knowledge that can ... seem to be able to sit still forever, and walk ... We will soon be able to buy smart new fasteners ... the fact is, sooner or later the grip is lost, ...
(Date:7/10/2014)... new alliance will see the two universities and NPL ... with business and industry and their complementary academic strengths., ... help to shape the scientific priorities of the UK. ... up to 300 high-calibre PhD students, will provide a ... NPL, the potential of the Laboratory will be grown ...
(Date:1/15/2014)... 15, 2014  Bill Jacobs Automotive, a group of car dealerships ... with the Heartland Blood Center and offering free oil change ... takes place Saturday, Jan. 18 at the Bill Jacobs Cadillac ... (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  The Bill ...
(Date:1/15/2014)... Look inside the new Preferred Solutions® catalog ... from fluid handling to instruments to supplies. Many items ... order. , Preferred Solutions features a full selection ... model for precise flow control and dispensing to I/P® ...
Breaking Biology Technology:Even geckos can lose their grip 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 2Universities of Surrey and Strathclyde selected as strategic partners in the future operation of the National Physical Laboratory 3Join the Bill Jacobs Auto blood drive and receive a free oil change 2Cole-Parmer Begins 2014 with the Release of Preferred Solutions 2
... peak in interest? And what do Xers care about? , ... finally. Today, 27 and 25 are the average ages of ... means pushing back adult realities and concerns. When a young ... Its just taken Xers a little longer to get there. ...
... has become a booming export business. Universities are expanding offshore ... from Asia, the South Pacific and the Middle Eastwho are ... education demand is so strong that sale of academic sheepskins ... lessons learned in the land down under should be noted ...
... to a close, the fourth quarter represents a fast and furious ... more important of these events: , , , ,Eleven ... activities! This is a good sign and bodes well for the ... Chicago. Its also an indicator that biotech is alive, prospering and ...
Cached Biology Technology:Presidential politics and the next generation 2Wisconsin can teach the world, and profit by it 2Wisconsin can teach the world, and profit by it 3Furious pace of Midwest biotech events marks progress 2Furious pace of Midwest biotech events marks progress 3
... Salmonella genomes has allowed the development of ... pairs. The S. enterica Typhimurium (strain LT2) ... bp; 4,440 ORFs) and a plasmid, pSLT ... Sigma-Genosys have been designed to amplify all ...
... The Bio-Stack Twister II Microplate ... top automation solution for integrating BioTeks ... together with expandable microplate capacity, ultimate ... Whether you are adding capacity to ...
XPLAC (S-17)...
Request Info...
Biology Products: