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In lung cancer, silencing one crucial gene disrupts normal functioning of genome
Date:12/30/2008

processes likely reinforce each other. Global hypomethylation associated with MTHFR inactivation contributes to development of cancer by destabilizing the chromosome and activating oncogenes.

The researchers also discovered that methylation levels in RASSF1A were influenced by gender men were much more likely to express this abnormally and that methylation levels of CDH1, CDKN2A, GSTP1 and RASSF1A were not associated with smoking.

While the findings contribute to the basic understanding of lung cancer development, they may also be useful in designing a "methylation signature" blood or sputum biomarker test to identify individuals who are at risk of developing the disease, the researchers say. "That may prove particularly beneficial in diagnosing patients exposed to passive smoking," Herceg said.


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Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Page: 1 2 3

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