Navigation Links
In lung cancer, silencing one crucial gene disrupts normal functioning of genome
Date:12/30/2008

PHILADELPHIA While examining patterns of DNA modification in lung cancer, a team of international researchers has discovered what they say is a surprising new mechanism. They say that "silencing" of a single gene in lung cancer led to a general impairment in genome-wide changes in cells, contributing to cancer development and progression.

In the January 1, 2009, issue of Cancer Research, a journal of the American Association for Cancer Research, they also report finding a strong link between modification of the key gene, MTHFR, and tobacco use by lung cancer patients even if the patient had smoked for a short period of time.

The findings reinforce tobacco's link to lung cancer development, but show that deactivating one specific gene through a process known as hypermethylation causes systemic dysfunction, or hypomethylation, in many genes, said the study's senior investigator, Zdenko Herceg, Ph.D., head of the Epigenetics Group at the International Agency for Research on Cancer (IARC).

"We found that tobacco-mediated hypermethylation of MTHFR, and consequent partial or complete silencing of the gene, may trigger global hypomethylation and deregulation of DNA synthesis, both of which may contribute to cancer development," he said.

This methylation process, which involves chemically modifying normal DNA in order to change its activity, is seen as an increasingly important factor contributing to so-called "epigenetic inheritance" in cancer development, Herceg said. An epigenetic event is when non-genetic factors cause a gene to change its expression, and this is different from cancer caused by mutated genes that produce errant protein.

"Tobacco smoke contains many carcinogens, most of which are believed to cause genome damage," he said. "While there is evidence that the mutations induced by these tobacco carcinogens do play an important role in cancer development, our study reveals the novel and surprising r
'/>"/>

Contact: Jeremy Moore
Jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

2

GOOD

Page: 1 2 3

Related biology news :

1. Avocados may help prevent oral cancer, OSU study shows
2. St. Jude identifies the specific cell that causes eye cancer, disproving long-held theory
3. Chemical in red wine, fruits and vegetables stops cancer, heart disease, depending on the dose
4. Exposure to low levels of radon appears to reduce the risk of lung cancer, new study finds
5. T-cadherin affects blood vessel growth in breast cancer, hormone from fat cells may play a role
6. Fruits, vegetables and teas may protect smokers from lung cancer, UCLA researchers report
7. Control switches found for immune cells that fight cancer, viral infection
8. Plasma DNA level is a reliable marker of recurrent esophageal cancer, study finds
9. Landmark study opens door to new cancer, aging treatments
10. Class of antibiotics can enhance gene-silencing tool
11. Cold Spring Harbor Protocols highlights gene silencing, cancer cell biology methods
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/21/2013)... most deadly when they metastasize and spread tumors throughout ... becomes very difficult for doctors to locate and treat ... the University of Missouri have found a way to ... they may be in the body. Michael Lewis, an ... Veterinary Medicine, says being able to target secondary tumors ...
(Date:5/21/2013)... uphill battle? Try staying fit in space, where living ... bone. , That,s the challenge a group of Michigan ... $1.2 million grant from NASA. Their goal is to ... , "You could give astronauts the best exercise regimen ... stick to it, it isn,t going to help," said ...
(Date:5/21/2013)... scientists have charted the path of insulin action in ... a comprehensive blueprint for understanding what goes wrong in ... Humphrey and Professor David James from Sydney,s Garvan Institute ... online edition of the prestigious journal Cell Metabolism ... plays a very important role in the body because ...
Breaking Biology News(10 mins):MU researchers develop radioactive nanoparticles that target cancer cells 2Fueling fitness on the final frontier 2Insight into the dazzling impact of insulin in cells 2Insight into the dazzling impact of insulin in cells 3
... In humans, the eyes are said to be the window ... intentions. New research demonstrates for the first time that birds ... to look at their prey when they attack, so direct ... at the University of Bristol, and her colleagues, set up ...
... could be harmful to the environment. For years, scientists ... and, recently, have used this knowledge to create consumer ... researcher has found that silver nanoparticles also may destroy ... wastewater treatment systems. The study was funded by a ...
... (April 29, 2008) Researchers discovered a legless lizard ... new species in Brazils Cerrado, one of the worlds ... once covered an area half the size of Europe, ... at twice the rate of the neighboring Amazon rainforest, ...
Cached Biology News:Are you looking at me? 2Too much technology may be killing beneficial bacteria 2New species discovered in Brazil 2
(Date:5/21/2013)... results of a new study led by George ... evidence that nucleation of ice in small droplets ... water,s behavior at the nanoscale. The formation of ... scientific research question whose answer also has important ... , The crystallization of ice from supercooled water ...
(Date:5/21/2013)... The congress of the ERA-EDTA ... the biggest congress in Europe ... are in Istanbul to share ... pioneering studies have been presented: / (1) ... VIA HEMODIALYSATE REDUCES ESA USE" By SFP-iron ...
(Date:5/21/2013)... Clinverse, Inc. , a global ... announced today it has formed a strategic alliance ... FLS eClinical commerce platform aggregates data collected through ... ™, Aggregate Spend Solutions’ recently-launched flagship product, is ... transfer of value at investigator meetings or any ...
(Date:5/21/2013)... , May 21, 2013 According ... Research ( http://www.transparencymarketresearch.com ) "Biochip Products and Services Market ... - U.S. Industry Analysis, Size, Share, Growth, Trends and Forecast, 2012 - 2018," ... 2011 and is expected to grow at a CAGR ... estimated value of USD 4.7 billion in 2018. ...
Breaking Biology Technology:Study led by GW professor provides better understanding of water's freezing behavior at nanoscale 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 2ERA-EDTA CONGRESS 2013: Late Breaking Clinical Trials 3Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 2Clinverse, Inc. Announces Strategic Alliance with Aggregate Spend Solutions, LLC 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 2The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 3The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 4The U.S. Biochip Products and Services Market is Expected to Reach USD 4.7 Billion in 2018: Transparency Market Research 5
...  Intellect Neurosciences, Inc. (OTCPK: ILNS) announces that Dr. ... will be presenting at the Seventh Annual Neurotech ... http://photos.prnewswire.com/prnh/20111214/NY22484LOGO ) The title of ... Attractive Targets for Active and Passive Immunotherapy." His ...
... Anesthesia Drugs Market (2011 - 2015) - U.S. Market Entry ... anesthesia drugs with special focus on ketamine, distribution structure of anesthesia drugs ... U.S. and U.S. market entry strategy. Browse market ... Anesthesia Drugs Market (2011 - 2015) -   U.S. ...
... April 12, 2011, nearly fifteen years after she became paralyzed ... by thinking about moving her arm and hand to lift ... drink. That achievement is one of the advances in brain-computer ... May 17 edition of the journal Nature by ...
Cached Biology Technology:Intellect Neurosciences, Inc. to Present at Neurotech Investing and Partnering Conference 2Intellect Neurosciences, Inc. to Present at Neurotech Investing and Partnering Conference 3Anesthesia Drugs Market in U.S. worth $7 Billion by 2015: MarketsandMarkets 2Anesthesia Drugs Market in U.S. worth $7 Billion by 2015: MarketsandMarkets 3People with paralysis control robotic arms to reach and grasp using brain computer interface 2People with paralysis control robotic arms to reach and grasp using brain computer interface 3People with paralysis control robotic arms to reach and grasp using brain computer interface 4People with paralysis control robotic arms to reach and grasp using brain computer interface 5
... 16-independent channels for automated gigaseal patch clamping. ... against voltage-gated ion channels, such as hERG ... The four pipette heads afford more ... channel drug discovery. The glass-coated tunnels ...
... Plating Beads Sterile plating in just ... rods and potentially hazardous ethanol flaming, More ... of ready-to-use sterile packaging: dispenser bottle for spreading ... Fastest and easiest way to spread ...
... successful cell culture or fermentation is the ... process, and make rapid adjustments in response ... Chemistry Analyzers provide immediate analysis of key ... and fermentation media. BioProfile analyzers are fully ...
... 17 amino acid synthetic peptide whose sequence is from rat SCAMP ... terminus): C - N(217) - Q - P - Q ... T - P - N - Y - T - Y ... for neutralization and control experiments with the polyclonal antibody that reacts ...
Biology Products: