Navigation Links
In diatom, scientists find genes that may level engineering hurdle
Date:1/21/2008

MADISON Denizens of oceans, lakes and even wet soil, diatoms are unicellular algae that encase themselves in intricately patterned, glass-like shells. Curiously, these tiny phytoplankton could be harboring the next big breakthrough in computer chips.

Diatoms build their hard cell walls by laying down submicron-sized lines of silica, a compound related to the key material of the semiconductor industrysilicon. If we can genetically control that process, we would have a whole new way of performing the nanofabrication used to make computer chips, says Michael Sussman, a University of Wisconsin-Madison biochemistry professor and director of the UW-Madisons Biotechnology Center.

To that end, a team led by Sussman and diatom expert Virginia Armbrust of the University of Washington has reported finding a set of 75 genes specifically involved in silica bioprocessing in the diatom Thalassiosira pseudonana, as published today in the online Early Edition of the Proceedings of the National Academy of Sciences. Armbrust, an oceanography professor who studies the ecological role of diatoms, headed up the effort to sequence the genome of T. pseudonana, which was completed in 2004.

The new data will enable Sussman to start manipulating the genes responsible for silica production and potentially harness them to produce lines on computer chips. This could vastly increase chip speed, Sussman says, because diatoms are capable of producing lines much smaller than current technology allows.

The semiconductor industry has been able to double the density of transistors on computer chips every few years. Theyve been doing that using photolithographic techniques for the past 30 years, explains Sussman. But they are actually hitting a wall now because theyre getting down to the resolution of visible light.

Before diatoms were appreciated for their engineering prowess, they interested ecologists for their role in the planets carbon cycle. These photosynthetic cells soak up carbon dioxide and then fall to the ocean floor. They account for upwards of 20 percent of the carbon dioxide that is removed from the atmosphere each year, an amount comparable to that removed by all of the planets rainforests combined.

We want to see which genes express under different environmental conditions because these organisms are so important in global carbon cycling, explains Thomas Mock, a postdoctoral researcher in Armbrusts lab and the papers first author.

But research on these algae has uncovered other enticing possibilities. As he learned about diatoms, Sussman became intrigued by the fact that each species of diatomthere may be around 100,000 of themis believed to sport a uniquely designed cell wall.

To determine which genes are involved in creating those distinctive patterns, the research team used a DNA chip developed by Sussman, UW-Madison electrical engineer Franco Cerrina and UW-Madison geneticist Fred Blattner, the three founders of the biotechnology company NimbleGen. Put simply, the chip allows scientists to see which genes are involved in a given cellular process. In this case, the chip identified genes that responded when diatoms were grown in low levels of silicic acid, the raw material they use to make silica.

Of the 30 genes that increased their expression the most during silicic acid starvation, 25 are completely new, displaying no similarities to known genes.

Now we know which of the organisms 13,000 genes are most likely to be involved in silica bioprocessing. Now we can zero in on those top 30 genes and start genetically manipulating them and see what happens, says Sussman.

For his part, Sussman is optimistic that in the long run these findings will help him improve the DNA chip he helped develop the very one used to gather data for this research project. Its like the Lion King song, he says. You know, the circle of life.


'/>"/>

Contact: Michael Sussman
msussman@wisc.edu
608-262-8608
University of Wisconsin-Madison
Source:Eurekalert

Related biology news :

1. Scientists call for urgent research into real impacts of invasive species
2. Scientists discover a new player in innate immune response
3. Scientists study the link between childrens nutrition and adult diseases
4. Scientists associate 6 new genetic variants with heart disease risk factor
5. CSHL scientists identify cells that promote formation of lethal lung metastases
6. Smithsonian scientists highlight environmental impacts of biofuels
7. Scientists find missing evolutionary link using tiny fungus crystal
8. Jefferson scientists studying the effects of high-dose vitamin C on non-Hodgkin lymphoma patients
9. Five young Hebrew University scientists win first competitive EU grants
10. Scientists find good news about methane bubbling up from the ocean floor
11. International scientists tackle obstacles to treating brain disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/20/2016)... 20, 2016 Securus Technologies, a leading ... for public safety, investigation, corrections and monitoring announced ... it has secured the final acceptance by all ... Managed Access Systems (MAS) installed. Furthermore, Securus will ... be installed by October, 2016. MAS distinguishes between ...
(Date:6/9/2016)... June 9, 2016 Paris ... Teleste,s video security solution to ensure the safety of people ... during the major tournament Teleste, an international ... and services, announced today that its video security solution will ... to back up public safety across the country. The system ...
(Date:6/2/2016)... 2016   The Weather Company , an IBM Business ... industry-first capability in which consumers will be able to interact ... questions via voice or text and receive relevant information about ... Marketers have long sought an advertising solution that can ... personal, relevant and valuable; and can scale across millions of ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... Calif. , June 23, 2016  The Prostate Cancer Foundation ... increasingly precise treatments and faster cures for prostate cancer. Members of the Class ... across 15 countries. Read More About the Class of ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case report published today in ... patient who developed lymphedema after being treated for breast cancer benefitted from an injection ... for dealing with this debilitating, frequent side effect of cancer treatment. , ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, ... Pennsylvania Convention Center and will showcase its product’s latest features from June 26 ... presenting a scientific poster on Disrupting Clinical Trials in The Cloud during the ...
(Date:6/22/2016)... 2016 Cell Applications, Inc. and StemoniX ... produce up to one billion human induced pluripotent ... week. These high-quality, consistent stem cells enable researchers ... spend more time doing meaningful, relevant research. This ... manufacturing process that produces affordable, reliable HiPSC for ...
Breaking Biology Technology: