Navigation Links
In a genetic research first, Mayo Clinic turns zebrafish genes off and on
Date:5/8/2011

ROCHESTER, Minn. Mayo Clinic researchers have designed a new tool for identifying protein function from genetic code. A team led by Stephen Ekker, Ph.D., succeeded in switching individual genes off and on in zebrafish, then observing embryonic and juvenile development. The study appears in the journal Nature Methods.

The work could help shed light on health-related problems such as how cancerous cells spread, what makes some people more prone to heart attacks, (http://www.mayoclinic.org/heart-attack/) or how genes factor in addiction. More complicated issues, like the genetics (http://www.mayoclinic.org/medical-genetics-rst/) of behavior, plasticity and cellular memory, stress, learning and epigenetics, could also be studied with this method.

The research at Mayo Clinic's (http://www.mayoclinic.org/) Zebrafish Core Facility (http://mayoresearch.mayo.edu/mayo/research/zcf/) could help further unify biology and genomics by describing the complex interrelations of DNA, gene function and gene-protein expression and migration. The study examines protein expression and function from 350 loci among the zebrafish's approximately 25,000 protein-encoding genes. Researchers plan to identify another 2,000 loci.

"I consider this particular system a toolbox for answering fundamental scientific questions," says Dr. Ekker, a Mayo Clinic molecular biologist and lead author of the article. "This opens up the door to a segment of biology that has been impossible or impractical with existing genomics research methods."

For the First Time

The study includes several technical firsts in genetic research. Those include a highly effective and reversible insertional transposon mutagen. In nearly all loci tested, e
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MARC travel awards announced for GSA Mouse Genetics Conference
2. Climbers leave rare plants genetic variation on the rocks
3. Scripps Research scientists create new genetic model of premature aging diseases
4. Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists
5. GW researchers reveal 18 novel subtype-dependent genetic variants for autism spectrum disorders and identify potential genetic markers for diagnostic screening
6. Plant hormone auxin triggers a genetic switch
7. Genetic mutation linked to lethal disease
8. Improvements in embryonic preimplantation genetic screening techniques
9. New genetic tool helps researchers to analyze cells most important functions
10. WSU receives DOD grant to determine common genetic link among Gulf War Illness patients
11. New genetic study helps to solve Darwins mystery about the ancient evolution of flowering plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/11/2014)... 09, 2014 Research and Markets ... ( http://www.researchandmarkets.com/research/9ql3kr/biometrics_market ) has announced the addition ... report to their offering. ... the adoption of multimodal biometric systems. Multimodal biometric ... individual for verification and identification purposes. This helps ...
(Date:12/10/2014)... , Dec. 9, 2014  Valencell, a leader ... is seeing a staggering demand from its licensees for ... Company revealed, is not solely coming from fitness and ... well. "A wearable is only as useful ... accuracy is the ultimate driver in long-term mass consumer ...
(Date:12/10/2014)... 9, 2014     ...   Jifflenow, a ... solutions for business-to-business (B2B) events, today announced a ... mobile near-field communication (NFC), Bluetooth low energy (BLE), ... http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow will integrate its ...
Breaking Biology News(10 mins):Biometrics Market in India 2015-2019: Key Vendors are 3M Cogent, NEC, Safran and Suprema 2Wearable Technology Products Demand Highly Accurate Biometric Technology 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3
... farmers worldwide to plant genetically modified (GM) cotton to ... several years by saving on pesticides have now been ... researchers at the American Agricultural Economics Association (AAEA) Annual ... that other pests are now attacking the GM cotton. ...
... after the end-Cretaceous mass extinction was much more chaotic ... shows that at certain times and places, plant and ... as they are today. The extinction took place 65.5 ... the beginning of the Cenozoic Era and the Paleocene ...
... five major food crops grown under carbon-dioxide levels ... bounty than those raised in earlier greenhouse and ... global food supplies could be at risk without ... are based on on-going open-air research at the ...
Cached Biology News:Bt cotton in China fails to reap profit after seven years 2Insect predation sheds light on food web recovery after the dinosaur extinction 2Insect predation sheds light on food web recovery after the dinosaur extinction 3Insect predation sheds light on food web recovery after the dinosaur extinction 4Food-crop yields in future greenhouse-gas conditions lower than expected 2
(Date:12/17/2014)... LEXINGTON, Mass. , Dec. 17, 2014   ... a biopharmaceutical company developing therapeutic products for rare disorders, ... Healthcare Conference being held in San Francisco, ... , President and Chief Executive Officer, will present on ... p.m. EST).  The presentation will be webcast live and ...
(Date:12/15/2014)... 2014 Organovo Holdings, Inc. (NYSE MKT: ... delivering breakthrough 3D bioprinting technology,  today celebrated continued ... its exVive3D TM Human Liver Tissue.  The ... commercial release on November 18, has been recognized ... awards for innovation. Most recently, on ...
(Date:12/15/2014)... , Dec. 15, 2014  Ascendis Pharma A/S, ... technology to address significant unmet medical needs, today ... Phase 2 pediatric study to evaluate once-weekly TransCon ... or GHD.  This interim analysis consists of 25 ... enrollment in the study, completing all six months ...
(Date:12/13/2014)... Clarassance, a privately held clinical-stage biotechnology ... Therabron Therapeutics , Inc. The new name is ... of structure in the lungs similar to branches on ... novel protein therapeutics for the treatment of respiratory diseases. ... the name to mark the company's escalation into the ...
Breaking Biology Technology:Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 2Organovo Celebrates a Positive 2014 Reception of its exVive3DTM Human Liver Tissue Product 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 2Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 3Ascendis Pharma A/S Announces Positive Six-Month Interim Results from a Phase 2 Pediatric Study of Once-Weekly TransCon Growth Hormone for the Treatment of Growth Hormone Deficiency 4Maryland-based Biotech Company's Path Forward in Treating Respiratory Diseases Sparks Name Change 2
... exhibit to open Thursday , Madison, Wis. ... exhibit on advances in nanotechnology, run by the university and ... p.m. on December 16 during a campus open house, with ... science fiction as the manufacture of tiny robots, has led ...
... opening passages of Alice in Wonderland , you should. ... accurate description of most modern IT projects. , ,The business-like ... always just out of reach around the next turn of ... dialog. The falling, tumbling, almost hallucinogenic quality of a workload ...
... the highway reconstruction efforts continue their development in downtown Milwaukee, ... spent on a Web site that will update people on ... Marquette Interchange Project was established in September by the ... on the interchange, HNTP and CH2M Hill ...
Cached Biology Technology:Tech Digest: Nanotechnology, GE Healthcare, NovaMed, PhysioGenix 2The IT drug Just say no? 2The IT drug Just say no? 3$685,000 too much for construction Web site, critics say 2$685,000 too much for construction Web site, critics say 3