Navigation Links
In a genetic research first, Mayo Clinic turns zebrafish genes off and on
Date:5/8/2011

ROCHESTER, Minn. Mayo Clinic researchers have designed a new tool for identifying protein function from genetic code. A team led by Stephen Ekker, Ph.D., succeeded in switching individual genes off and on in zebrafish, then observing embryonic and juvenile development. The study appears in the journal Nature Methods.

The work could help shed light on health-related problems such as how cancerous cells spread, what makes some people more prone to heart attacks, (http://www.mayoclinic.org/heart-attack/) or how genes factor in addiction. More complicated issues, like the genetics (http://www.mayoclinic.org/medical-genetics-rst/) of behavior, plasticity and cellular memory, stress, learning and epigenetics, could also be studied with this method.

The research at Mayo Clinic's (http://www.mayoclinic.org/) Zebrafish Core Facility (http://mayoresearch.mayo.edu/mayo/research/zcf/) could help further unify biology and genomics by describing the complex interrelations of DNA, gene function and gene-protein expression and migration. The study examines protein expression and function from 350 loci among the zebrafish's approximately 25,000 protein-encoding genes. Researchers plan to identify another 2,000 loci.

"I consider this particular system a toolbox for answering fundamental scientific questions," says Dr. Ekker, a Mayo Clinic molecular biologist and lead author of the article. "This opens up the door to a segment of biology that has been impossible or impractical with existing genomics research methods."

For the First Time

The study includes several technical firsts in genetic research. Those include a highly effective and reversible insertional transposon mutagen. In nearly all loci tested, e
'/>"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. MARC travel awards announced for GSA Mouse Genetics Conference
2. Climbers leave rare plants genetic variation on the rocks
3. Scripps Research scientists create new genetic model of premature aging diseases
4. Mutant mouse reveals new wrinkle in genetic code, say UCSF scientists
5. GW researchers reveal 18 novel subtype-dependent genetic variants for autism spectrum disorders and identify potential genetic markers for diagnostic screening
6. Plant hormone auxin triggers a genetic switch
7. Genetic mutation linked to lethal disease
8. Improvements in embryonic preimplantation genetic screening techniques
9. New genetic tool helps researchers to analyze cells most important functions
10. WSU receives DOD grant to determine common genetic link among Gulf War Illness patients
11. New genetic study helps to solve Darwins mystery about the ancient evolution of flowering plants
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/16/2014)... and Mary,s Virginia Institute of Marine Science have ... Protection Agency to identify the streams and wetlands ... tools to help local governments and citizens conserve ... on a dataset of tidal-marsh observations first gathered ... this historical baseline can today,s researchers accurately map ...
(Date:10/16/2014)... are anything but sustainable: environmental damage to soil ... increasingly evident. Despite their disadvantages, however, monocultures remain ... the sole possibility of achieving higher yields in ... an ecology professor at the University of Zurich, ... forestry. After all, a new study carried out ...
(Date:10/16/2014)... -- NXT-ID, Inc. (NASDAQ: NXTD and ... focused on the growing mobile commerce market announces that ... Smart Wallet, at the 13 th annual Future ... conference on the intersection of technology and the economy. ... founder and publisher of the Strategic News Service™, the ...
Breaking Biology News(10 mins):EPA grant will help localities conserve headwater wetlands 2EPA grant will help localities conserve headwater wetlands 3Plant communities produce greater yield than monocultures 2Plant communities produce greater yield than monocultures 3NXT-ID Inc. to Present at 13th Annual FiRe Conference 2NXT-ID Inc. to Present at 13th Annual FiRe Conference 3
... David Schindler has reviewed data from studies of controlling ... input of the nutrient phosphorus is the key to ... controlling the human input of both nitrogen and phosphorus ... blooms., In contrast, Schindler concluded that only phosphorus control ...
... new study by researchers from the Global Change Institute ... Excellence for Coral Reef Studies at James Cook University, ... managed marine protected areas within Fiji are playing an ... inshore habitats. , The study estimates that by ...
... Fred Hutchinson Cancer Research Center, has been honored ... expert in virology, immunology and vaccine development, Corey,s ... viral infections, particularly those associated with cancer. "Corey,s ... of daily antiviral treatment for immunocompetent persons," explains ...
Cached Biology News:In Fiji, marine protection gets local boost 2The American Society for Microbiology honors Lawrence Corey 2The American Society for Microbiology honors Lawrence Corey 3
(Date:10/25/2014)... 23, 2014 ViaDerma, Inc ... company devoted to bringing new products to market, ... , ViaDerma has developed an innovative, patent-pending dual ... mass transfer of pharmaceutical active ingredients to penetrate ... immediate localized therapy. The transdermal delivery method also ...
(Date:10/25/2014)... Va. (PRWEB) October 24, 2014 ... the nation’s leading nonprofit authority on the ... healthcare information exchange, announces its appointment of four ... Workgroup. The workgroup leaders include:, , ... ,     Erik Pupo, Specialist Leader, Deloitte Consulting ...
(Date:10/25/2014)... A new way to produce engineered skin ... skin grafting technologies, it also speeds up the healing ... in the October issue of STEM CELLS Translational Medicine, ... that result from severe burns and chronic wounds. , ... elements. These wounds heal by contraction, with epithelization (the ...
(Date:10/25/2014)... Md. , Oct. 24, 2014  RegeneRx Biopharmaceuticals, Inc. ... data presented at the Fourth International Symposium on Thymosins ... , Italy.  "When thymosin beta 4 ... injected into the peritoneal cavity in a rodent model ... and throughout the brain parenchyma (the functional tissue of ...
Breaking Biology Technology:ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 2ViaDerma, Inc. Announces Plans to Pursue Out-Licensing Partnerships in 2015 3WEDI Appoints Four New Security and Privacy Workgroup Co-chairs 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 2New engineering method shows promise for faster healing, more cosmetically appealing skin grafts 3Researchers Report Thymosin Beta 4 Crosses Blood-Brain Barrier In Animal Stroke Model 2
... News Facts, , ... life sciences industry -- including,biopharmaceutical companies, contract ... increasingly turning to Oracle(R) Remote,Data Capture (RDC) ... effectively. , , -- ...
... Mealey,s Conferences (now HB,Litigation Conferences) released its upcoming schedule ... for women in the legal profession. , , ... 22 - Asbestos Gaskets: Exposure and the State of the ... , February 5 - Nanotechnology: ...
... Jan. 20 Amgen (Nasdaq: AMGN ) today ... full year financial results on Monday, Jan. 26, 2009 after ... followed by a conference call with the investment community at ... Amgen will be Kevin Sharer, chairman and chief executive officer, ...
Cached Biology Technology:Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 2Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 3Life Sciences Organizations Choose Oracle to Accelerate and Simplify Clinical Trial Data Collection 4Asbestos, Pharmaceutical Liability, Construction Defects, Nanotech: Covered by Targeted CLE Teleconferences 2Amgen Announces Webcast of 2008 Fourth Quarter and Full Year Financial Results 2
... number is a new product ... Cornings product number. If showing ... under the old Sigma-Aldrich number ... for assistance. ID clarifier: box ...
... 96-well Cell Invasion Assay is designed to ... laminin as a significant barrier to invasion ... vitro in a convenient, high-throughput, 96-well format. ... for all types of adherent cells such ...
... The GrabIt™ Kits are designed for the ... using a pull-down method. Proteins that interact ... fusion proteins are copurified using affinity ... are retained on a spin filter. The ...
Kit containing MACS equipment and reagents for immunopurification of proteins....
Biology Products: