Navigation Links
In a fight to the finish, Saint Louis University research aims knockout punch at hepatitis B
Date:2/4/2013

fit, but it should serve the same function."

Once the assay for the RNAseH was developed, Tavis and his team were able to try out this theory.

"We found that what worked with the first enzyme worked with the second enzyme," Tavis said. "This is a proof of principle. We're on the right track."

Tavis now has a measuring tool and evidence that a number of the techniques that stopped HIV, including inhibitors of HIV RNAseH, could also inhibit the hepatitis B virus RNAseH, showing that the parallels held true. From there, Tavis and his team went on to prove that hepatitis B replication could in fact be stopped in cells with drugs that targeted the elusive second enzyme, RNAseH.

Hope on the Horizon

With these promising advances, researchers say that the search for anti-hepatitis B RNAseH drugs is now feasible and that using similar anti-HIV compounds as a guide is likely to have a high chance of success.

The research team's next step will be to study several variations of hepatitis B virus, different genotypes of the virus, to be able to measure and study the RNAseH enzyme in all forms of the virus. Current findings demonstrated success in only some genotypes. Findings from the current study suggest some promising avenues as researchers will now attempt to block RNAseH in the two most common genotypes, B and C.

In addition, researchers will aim to improve the strength and speed of the RNAseH assay for high throughput screening, a process for rapidly screening many thousands of compounds. These developments will clear the way for full-scale antiviral drug discovery.

Investigators have reason to hope that combining a new anti-hepatitis B RNAseH drug with the existing drugs may suppress the virus far enough to cure patients with hepatitis B.

"I anticipate a new drug targeting the second enzyme would be used together with the existing drugs," Tavis said. "They jam different parts of the
'/>"/>

Contact: Carrie Bebermeyer
bebermcl@slu.edu
314-977-8015
Saint Louis University
Source:Eurekalert

Page: 1 2 3 4 5

Related biology news :

1. UC research: Tracking Lake Erie water snake in fight against invasive fish
2. Young researcher taking fight against global killer to the next level in Vietnam
3. Evolving to fight epidemics: Weakness can be an advantage
4. Preventing home invasions means fighting side-by-side for coral-dwelling crabs and shrimp
5. Study shows botanical formula fights prostate cancer
6. Buy coal? New analysis shows purchasing fossil fuel deposits best way to fight climate change
7. Study finds cancer-fighting goodness in cholesterol
8. Trial launched into curry chemicals cancer-fighting properties
9. Canadian girl, 16, invents disease-fighting, anti-aging compound using tree particles
10. Biosensor illuminates compounds to aid fight against TB
11. Fighting bacterias strength in numbers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... Fla. , Sept. 16, 2014  Cross ... identity management solutions, announced today the launch of ... to authenticate the identity of an individual using ... Android-based Verifier Sentry rapidly reads credential documents with ... ID by matching the biometric to a live ...
(Date:9/15/2014)... 15, 2014) The so-called central dogma of ... long provided a simplified explanation for how genetic ... , In reality, of course, the process ... articulated nearly 60 years ago by Nobel Laureate ... For one, there are multiple types of RNA, ...
(Date:9/15/2014)... research has determined that a single group of microorganisms ... B12 production in the oceans, with implications for the ... B12 is an essential molecule required by most life ... relatively small group of microorganisms because it is so ... key role in maintaining the brain and nervous systems, ...
Breaking Biology News(10 mins):Cross Match Launches New Identity Management Handheld Solution 2Scientists discover RNA modifications in some unexpected places 2Researchers discover new producer of crucial vitamin 2
... Johnson & Johnson today announced that Axel Ullrich, Ph.D., ... Max Planck Institute of Biochemistry in Germany, whose discoveries ... , is the winner of the 2009 Dr. Paul ... of world-renowned scientists selected Dr. Ullrich, who on September ...
... mice responsible for repairing DNA strands damaged by oxidation ... that such stress contributes to the development of cancer. ... DNA Repair by researchers at the National Institute ... University (OHSU) and the New York University School of ...
... time, scientists have shown that chromosomal abnormalities are present ... produced by young, fertile couples. Ms Evelyne Vanneste, a ... the University Fertility Center, Leuven University, Belgium, told the ... Reproduction and Embryology today (Wednesday July 1), that the ...
Cached Biology News:Axel Ullrich named winner of 2009 Dr. Paul Janssen Award for Biomedical Research 2Genetically engineered mice yield clues to 'knocking out' cancer 2Chromosomal problems affect nearly all human embryos 2Chromosomal problems affect nearly all human embryos 3
(Date:9/16/2014)... According to Jeff Howell, Partner of Nidea Corporate ... development in Downtown Toronto is expanding at a blistering ... storeys of new development last week (including three new ... the Toronto skyline for the foreseeable future in a ... new development. , As the Toronto city council met ...
(Date:9/15/2014)... UPTON, NYHeat drives classical phase transitionsthink solid, ... happen when the temperature drops. If phase ... where quantum mechanics reigns, subtle fluctuations can ... from the U.S. Department of Energy,s Brookhaven ... explored this frigid landscape of absolute zero ...
(Date:9/15/2014)... United States (PRWEB) September 16, 2014 ... Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies is ... This report focuses on the three principal types ... of research and development in cancer immunotherapy (which ... inhibitors, Therapeutic anticancer vaccines and Adoptive cellular immunotherapy. ...
(Date:9/15/2014)... SAN JOSE, Calif. , Sept. 15, 2014 ... for Proposals (RFP) for flexible, printed product demonstrators ... conducts a two-stage RFP process with pre-proposals due ... in January 2015.  Funds for proposals ultimately selected ... (ARL) and have a significant cost share by ...
Breaking Biology Technology:ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 2ITRA Global Reports Downtown Toronto Real Estate Development is in High Gear 3Elusive quantum transformations found near absolute zero 2Elusive quantum transformations found near absolute zero 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 2Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 3Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 4Cancer Immunotherapy Market: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies 5FlexTech Alliance Issues 2015 Request for Proposals in Flexible, Printed Electronics 2
... Anesiva,Inc. (Nasdaq: ANSV ) announced today the ... directors. Mr. Janney previously served on Anesiva,s,board from November ... following the merger of Anesiva and AlgoRx Pharmaceuticals., ... of directors,and we are very pleased to welcome him ...
... Inc.,today announced that Edward L. Jacobs, president and ... medical officer,will present an update of the company,s ... Feb. 13, 2008, at the BIO CEO & ... will include information about Semafore,s lead product,candidate, SF1126, ...
... Diagnostic Imaging,International Corp. (OTCBB: DIIG) announced today that ... imaging clinics for acquisition., Following the Company,s ... of profitable operating clinics as well as open ... begun its diligence review on clinics that have,been ...
Cached Biology Technology:Anesiva Appoints Daniel Janney to Board of Directors 2Anesiva Appoints Daniel Janney to Board of Directors 3Semafore to Present at BIO CEO & Investor Conference 2Diagnostic Imaging - Acquisitions - OTCBB: DIIG 2
All serum is collected from U.S.D.A. fryers and broilers. Pricing: $15/unit for 1 - 10 units; $12/unit for 11 - 50 units...
Whole blood is collected from healthy pigs (mixed breed, either sex) at the time of slaughter, refrigerated within 6 hours, processed within 24 hours and frozen at -20ºC....
Human/Mouse/Rat Keap1 MAb (Clone 333116) Protein Family: Transcription Factor Regulators...
Collected from sexually mature, mixed sex, mixed breed guinea pigs. Pricing: $120/unit for 1 - 10 units...
Biology Products: