Navigation Links
In Parkinson's disease, brain cells abandon mitochondria, researchers report
Date:10/7/2010

In a study that sheds new light on the causes of Parkinson's disease, researchers report that brain cells in Parkinson's patients abandon their energy-producing machinery, the mitochondria. A shutdown in fuel can have devastating effects on brain cells, which consume roughly 20 percent of the body's energy despite making up only 2 percent of body weight.

The findings indicate that boosting the mitochondria with FDA approved drugs early on may prevent or delay the onset of Parkinson's. The study will be published in the one-year anniversary issue of the journal Science Translational Medicine, on Wednesday October 6 2010. Science Translational Medicine is published by AAAS, the nonprofit science society.

Affecting roughly 5 million people worldwide, Parkinson's disease is a relentless condition that starts killing dopamine neurons in the brain many years before the onset of hallmark symptoms like tremors, muscle rigidity and slow movements. Thus, much-needed drugs to slow or halt the disease would have the greatest benefit for patients if they are given early on, before too many dopamine neurons die.

Clemens Scherzer from Brigham and Women's Hospital and Harvard Medical School, along with an international team of researchers, now show that a root cause of Parkinson's disease may lie in 10 gene sets related to energy production that spur neurons in the brain to "divorce" their mitochondria and related energy-producing pathways.

These gene sets are controlled by a master regulatorthe PGC-1alpha gene. Moreover, abnormal expression of these genes likely occurs during the initial stages of Parkinson's disease, long before the onset of symptoms, the study shows. Targeting PGC-1alpha may thus be an effective way to slow down or halt the earliest stages of Parkinson's, staving off permanent damage and neuronal loss.

"The most exciting result from our study for me is the discovery of PGC-1alpha<
'/>"/>

Contact: Natasha Pinol
npinol@aaas.org
202-326-7088
American Association for the Advancement of Science
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Protein important in diabetes may also play a key role in heart disease, other disorders
2. TGen-led studies identify genetic links to kidney disease, kidney failure
3. Policy unveiled to combat diarrheal disease, a killer of Kenyan children
4. Second-hand smoking results in liver disease, study finds
5. While focusing on heart disease, researchers discover new tactic against fatal muscular dystrophy
6. MIT researchers develop a better way to see molecules at work in living brain cells
7. Brown Institute for Brain Science marks decade of research impact
8. Scarless brain surgery is new option for patients
9. New invention could improve treatment for children with water on the brain
10. Toward the first nose drops to treat brain cancer
11. Brain cell communication: Why its so fast
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/30/2014)... September 30, 2014--Sea monkeys have captured the popular attention ... easily observable life cycle -- sold as dehydrated eggs, ... given little more than a tank of salt water. ... pattern: Like other zooplankton, brine shrimp vertically migrate in ... closer to the surface at night and retreating deeper ...
(Date:9/30/2014)... and engineers, led by Clemson University associate professor ... grant from the U.S. Department of Energy,s Experimental ... direct positive impact on South Carolina in the ... contaminants. , "Understanding the scientific and engineering needs ... of nuclear technologies is imperative if South Carolina ...
(Date:9/30/2014)... almost any aquatic environment on Earth, but when the ... pushed to the limit. The amount of time needed ... how different species cope in the future, reveals a ... published in the scientific journal Proceedings of the ... thanks to increasing levels of greenhouse gases in the ...
Breaking Biology News(10 mins):Laser-guided sea monkeys show how zooplankton migrations may affect global ocean currents 2Researchers get $5.25 million to advance nuclear technologies in South Carolina 2Shape up quickly -- applies to fish, too! 2
... thought to be only a structural support protein in the ... its cross-like shape. However, laminin is far more ... studies led by one of the world,s foremost breast cancer ... the development of breast cancer, ,the second most common cancer ...
... development, sensory and motor fibers interact to form nerves ... Andrea Huber Brsamle of the Institute of Developmental Genetics ... interaction functions at the molecular level: The cell surface ... nerve fibers and controls their interaction in order to ...
... All our daily activities, from driving to work to solving ... vast network of neurons. Propagation of these signals is, in ... receptors, ion channels, and transmitters -- turning on and off ... in real time has not been possible, but researchers at ...
Cached Biology News:Berkeley Lab researchers illuminate laminin's role in cancer formation 2Berkeley Lab researchers illuminate laminin's role in cancer formation 3Berkeley Lab researchers illuminate laminin's role in cancer formation 4Berkeley Lab researchers illuminate laminin's role in cancer formation 5
(Date:9/30/2014)... 30, 2014 Nematicide is a type ... are microscopic parasitic roundworms, found in massive quantities ... plants and animals. Nematicides have tended to be ... promoting migration through the soil. A single gram ... nematodes. With more than 10,000 species classified, they ...
(Date:9/30/2014)... September 30, 2014 Follow us ... of each type of cholesterol carrier or lipoprotein in ... of excessive cholesterol levels in the body, especially along ... to heart attack and other cardiovascular disorders. Cardiovascular Diseases ... testing for cholesterol levels on a regular basis, to ...
(Date:9/30/2014)... BUDAPEST, Hungary , September 30, 2014 /PRNewswire/ ... libraries and intuitive browsing of chemistry in documents ... providing chemistry software solutions and consulting services for ... extract chemical information and generate Markush structures from ... securing an organizations intellectual property, however generating and ...
(Date:9/30/2014)...  KemPharm, Inc., a clinical-stage specialty pharmaceutical company ... new molecular entity (NME) prodrugs, announced today that ... issued U.S. Patent No. 8,816,083 to KemPharm for ... Derivatives and Heteroaryl Carboxylic Acid Conjugates of Hydromorphone, ... The patent, which extends through 2032, provides ...
Breaking Biology Technology:Nematicides Market by Types (Fumigants, Organophosphates, Carbamate and Bio-Nematicides), Applications (Agrochemicals, Industrial, and Others), and Geography (North America, Europe, Asia-Pacific & ROW) - Global Trends & Forecasts to 2019 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4ChemAxon Introduces ChemCurator for Chemical Information Extraction and Markush Structure Creation 2KemPharm, Inc. Receives Patent from the USPTO for Novel Prodrug of Hydromorphone, KP511 2
... /PRNewswire-Asia-FirstCall/ -- American Oriental Bioengineering, Inc. (NYSE: ... pharmaceutical company dedicated to improving health through the ... of prescription and over–the-counter ("OTC") products, today announced ... 31, 2011. First Quarter 2011 ...
... May 9, 2011 Netsmart Technologies, Inc., ... and human services organizations, today announced that Michael Valentine ... Valentine will join Netsmart from Cerner Corporation, where he ... He will succeed James Conway, who is retiring after ...
... SUNNYVALE, Calif., May 9, 2011 Accuray ... in the field of radiosurgery, announced today that the ... company,s Form S-4 Registration Statement relating to the previously ... statement/prospectus contained in the registration statement will first be ...
Cached Biology Technology:American Oriental Bioengineering Reports First Quarter 2011 Financial Results 2American Oriental Bioengineering Reports First Quarter 2011 Financial Results 3American Oriental Bioengineering Reports First Quarter 2011 Financial Results 4American Oriental Bioengineering Reports First Quarter 2011 Financial Results 5Netsmart Technologies Names Michael Valentine as Chief Executive Officer 2Netsmart Technologies Names Michael Valentine as Chief Executive Officer 3SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 2SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 3SEC Declares Accuray Form S-4 Registration Statement Effective in Proposed Acquisition of TomoTherapy 4
ANTI CORTIS BIN GLOB...
ANTI S. ENTERID LPS...
... Development kit contains the basic components required ... measure natural and recombinant rat L-Selectin in ... kit contains sufficient materials to run ELISAs ... the following conditions are met: ...
...
Biology Products: