Navigation Links
Improving the odds
Date:12/7/2009

Although bone marrow transplants have long been standard for acute leukemia, current treatments still rely on exact matches between donor and patient. Now, scientists at the University of Perugia, Italy, and the Weizmann Institute of Science have improved on a method of transplanting bone marrow-based stem cells from a mismatched donor, making it safer for use when no exact match exists. They were invited to present their findings at the recent annual American Society of Hematology conference in New Orleans.

More than a decade ago, Prof. Yair Reisner of the Weizmann Institute's Immunology Department pioneered a method for transplanting stem cells from family members who are a partial match. Based on these studies (in mice), he joined forces with Prof. Massimo F. Martelli, Head of the Hematology and Clinical Immunology Section at the University of Perugia, to demonstrate in more than 300 patients that the cure rate of these so-called "mega dose" transplants is similar to that of transplants from matched, unrelated donors picked from international bone marrow donor registries. To combat the body's tendency to reject the foreign cells, these stem cells are stripped of immune cells called T cells and given in high doses that overwhelm the host's own immune system. Although removing donor T cells from the bone marrow reduces the risk of graft-versus-host disease caused when the T cells attack the recipient's tissues the immune system is slow to recover after the transplant, leaving the patient at risk of serious infection. Doctors are faced with a difficult choice: Either remove the T cells from the bone marrow, increasing the risk of infection, or leave the T cells in the graft, putting the patient at risk for lethal graft-versus-host disease.

Martelli, working with Reisner, has now found a way to facilitate the recovery of the immune responses in recipients of T cell-depleted bone marrow transplants. In a clinical trial, 25 of 26 leukemia
'/>"/>

Contact: Yivsam Azgad
news@weizmann.ac.il
972-893-43856
Weizmann Institute of Science
Source:Eurekalert

Page: 1 2

Related biology news :

1. Improving livestock productivity in Honduras
2. Greatest thing since sliced bread: New data offer important clues toward improving wheat yields
3. High blood sugars impact on immune system holds clues to improving islet cell transplants
4. Improving our ability to peek inside molecules
5. Improving industry efficiency through environmental innovations
6. Biodegradable polymers show promise for improving treatment of acute inflammatory diseases
7. Improving swine waste fertilizer
8. Stroke study reveals key target for improving treatment and suggests that Gleevec may help
9. NOAA study shows eastern tropical pacific ocean dolphin populations improving
10. Improving care and knowledge in translational research to fight breast cancer
11. Improving detection of nuclear smuggling goal of computer model of mechanical engineer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2015)... , March 24, 2015   Crossmatch ... solutions, today announced that its U.are.U ® ... retailer Goorin Bros . to achieve PCI ... solution secures access to the POS terminal, protecting ... risk of data breaches. With ...
(Date:3/23/2015)...  In the 2014 fiscal year, irs.gov recorded over ... figure accounts for a fraction of the estimated losses ... exceeds $11 billion globally. The polygraph has traditionally been ... occurred. Investor Mark Saint Juste along with ... partnered to administer the test in a new ...
(Date:3/20/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/rswjb4/hand_geometry ) ... Global Strategic Business Report" report to their offering. ... in US$ Thousands. The report provides separate comprehensive analytics for ... , Europe , Asia-Pacific ... of World. Annual estimates and forecasts are provided ...
Breaking Biology News(10 mins):Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 2Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 3Hand Geometry - Global Strategic Business Report 2015: An Essential Security Component for both Government & Enterprise Sector 4
... international team of researchers that includes James Kennett, professor ... a nearly 13,000-year-old layer of thin, dark sediment buried ... The sediment layer contains an exotic assemblage of materials, ... the researchers, are the result of a cosmic body ...
... material that control protein formation in the brain, Johns Hopkins ... made and how drugs might someday be used to stop ... brain wasting diseases. In a report published in the ... elements that control which proteins get made in cells are ...
... , New research from the University of California shows how ... like an eye. As published today (March 5) in ... on the stinging mechanism in the tiny, brainless and eyeless ... called cnidarians that includes sea anemones, corals and jellyfish, a ...
Cached Biology News:Study jointly led by UCSB researcher supports theory of extraterrestrial impact 2Making memories: How 1 protein does it 2Making memories: How 1 protein does it 3
(Date:3/26/2015)... Neogen Corporation (NASDAQ: NEOG ) announced today that ... 2015, which ended Feb. 28, increased 13% to $7,454,000, ... share in the current quarter were $0.20, compared to ... 17% over prior year to $24,142,000, or $0.65 per ... the same period a year ago. Revenues ...
(Date:3/26/2015)... (PRWEB) March 26, 2015 ReliantHeart, Inc., ... and Transonic, a supplier of precision transit-time flow measurement ... will greatly improve the efficiency of the HeartAssist5® ... LVAD patients to experience greater mobility and peace of ... the miniature flow board, will draw 1/6th of the ...
(Date:3/26/2015)... March 26, 2015 Ale Gicqueau, Founder ... Director of Clinical Affairs at Align Technology, on “ ... the upcoming ACRP 2015 Global Conference and Exhibition on ... Utah. , During the poster presentation, Ale Gicqueau ... and running a Postmarket Registry, the requirements and resources ...
(Date:3/25/2015)... one of the most attractive in the emerging European ... growing economy and increasing government investment in healthcare, according ... market is set to grow at twice the pace ... 10-15% annually reaching an approximate market value of $43-60 ... Green Cross provides total healthcare solutions that address ...
Breaking Biology Technology:Neogen reports 13% increase in net income 2Neogen reports 13% increase in net income 3Neogen reports 13% increase in net income 4Neogen reports 13% increase in net income 5Neogen reports 13% increase in net income 6Neogen reports 13% increase in net income 7Neogen reports 13% increase in net income 8LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 2LVAD patients to have greater mobility and peace of mind through Transonic and ReliantHeart’s True Flow collaboration for the HeartAssist5® 3Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 2Clinovo Presents at ACRP 2015 in Salt Lake City, Utah on April 25th-28th 3
... announced,today that its vegetable seed business Nunhems has ... in Salinas, California, Paragon Seed,specialises in the breeding, ... sales of US-Dollar 8.5 million 2006 [approximately EUR ... United States in this segment,and supplies the U.S. ...
... VivoMetrics Inc., a provider,of leading edge non-invasive vital ... to the position of president and chief,executive officer. ... with,the company in the role of executive vice ... 28 years in leadership roles:,developing global markets, commercializing ...
... MEETING, Pa., Dec. 12 Genaera,Corporation (Nasdaq: GENR ... Officer of Genaera, is scheduled to present at the ... of an,RBC Capital Markets, panel discussion of diabetes and ... will take place in,New York on Thursday, December 13 ...
Cached Biology Technology:Bayer CropScience's Vegetable Seed Business Nunhems Acquires US Lettuce Seed Company Paragon Seed 2Bayer CropScience's Vegetable Seed Business Nunhems Acquires US Lettuce Seed Company Paragon Seed 3VivoMetrics(R) Appoints Howard R. Baker as New President and Chief Executive Officer 2
... routine agarose gel electrophoresis into an automated, ... This bufferless, pre-cast system is ideal for ... digests, and more. Fully automated, robot-compatible, and ... 96 system makes your high-throughput screening assignments ...
SpectroQuest single beam 4nm UV/Vis spectrophotometer; stand-alone unit; large angled LCD screen; large sample compartment...
... 40 reactions. Optimized for the rapid ... products with blunt or sticky ends.Replaces ... consistently better signal-to-noise ratios and as ... generated by proof-reading thermostable polymerases are ...
... Immunogen: Synthetic peptide derived from ... WNT2B/WNT13 protein. Specificity: Specific for ... rat WNT2B/WNT13 proteins. Recognizes both human ... Mouse Human Rat (positive controls: mouse ...
Biology Products: