Navigation Links
Improving the development of new cancer models using an advanced biomedical imaging method
Date:12/17/2012

Scientists at the University of Arizona Cancer Center and the Moffitt Cancer Center, led by Dr. Robert Gillies, have demonstrated that an advanced magnetic resonance imaging (MRI) method can non-invasively evaluate the cellular proliferation of tumor models of breast cancer. This quantitative imaging method evaluates the diffusion of water in tumor tissue, which correlates with the growth rates of the tumor models. The results, which appear in the November 2012 issue of Experimental Biology and Medicine, can contribute to the development of new tumor models for cancer research.

"In the absence of imaging such as we describe here, developers of tumor models are flying blind" says Dr. Gillies. "In this study, we show that the behavior of water in tissues can provide important information about tumor development. More specifically, the mobility of water is inhibited by biological barriers such as cell membranes, so that decreased mobility can be used as a measure of cell density and proliferation in tumor models."

The development of new tumor models is a high priority for current cancer research. Yet creating new pre-clinical tumor models from cancer cells obtained from patients is a laborious process with a low potential for success. Dr. Marty Pagel, co-investigator on the study states that "noninvasive, quantitative imaging techniques have potential to accelerate and improve the success of establishing new tumor models for innovative cancer studies."

Dr. Steven R. Goodman, Editor-in-Chief of Experimental Biology and Medicine said "This exciting study by Gillies and colleagues demonstrates that a Diffusion Weighted MRI technique provides a quantitative measure of tumor development in models of breast cancer. Such a non-invasive method will allow for the development of new tumor models that can be used for the development of improved therapies for breast cancer".


'/>"/>
Contact: Dr. Robert J. Gillies
robert.gillies@moffitt.org
Society for Experimental Biology and Medicine
Source:Eurekalert

Page: 1

Related biology news :

1. Genetic research develops tools for studying diseases, improving regenerative treatment
2. Interventional radiology: Mitigating symptoms, improving quality of life of MS patients
3. Improving equine health: Research studies vaccinations to protect newborn foals
4. Global Surgical Devices Market Growth Driven by Improving Standards of Living and Longer Life Expectancies, Research Shows
5. Validity CTO to Present Natural ID Solutions for Improving Mobile Risk Management and User Experience at NFC Solutions Summit 2012
6. Waste to watts: Improving microbial fuel cells
7. Improving water quality can help save coral reefs
8. GOCEs second mission improving gravity map
9. U of Minn. receives $1.8 million grant for improving efficiencies in fuel and plastics production
10. Artificial womb unlocks secrets of early embryo development
11. REST is crucial for the timing of brain development
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... Dec. 14, 2016 "Increase in mobile transactions ... The mobile biometrics market is expected to grow from ... by 2022, at a CAGR of 29.3% between 2016 ... as the growing demand for smart devices, government initiatives, ... "Software component is expected to grow at a ...
(Date:12/7/2016)... India , December 7, 2016 According to a ... Machine Learning), Software Tool (Facial Expression, Voice Recognition), Service, Application Area, End User, ... is estimated to grow from USD 6.72 Billion in 2016 to USD 36.07 ... Continue Reading ... ...
(Date:12/6/2016)...  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) (the ... €500.0 million principal amount of its 1.414% senior unsecured notes ... senior unsecured notes due 2026. The closing ... subject to the satisfaction of customary closing conditions.  The notes ... The Company intends to use the net proceeds ...
Breaking Biology News(10 mins):
(Date:1/17/2017)... Jan. 17, 2017 Noom Inc. ... the first to offer fully Spanish behavior change ... Noom,s Spanish diabetes prevention and healthy weight ... accessibility of lifestyle interventions among Hispanic Americans who ... Noom,s robust food database, program-specific curriculum content and ...
(Date:1/17/2017)... Jan. 17, 2017  Northwell Health today announced ... of precision cancer research. As ... health care provider, Northwell Health diagnoses and treats ... is a Germany -based oncology ... Together they will greatly expand cancer biobanking activities ...
(Date:1/17/2017)... ... January 17, 2017 , ... One ... Technology Consortium™ (SafeTEC™), $3 million in investment towards 15+ TEC Validation Projects™. As ... assays, and their applicability in drug safety assessment, for the industry as a ...
(Date:1/17/2017)... MILPITAS, Calif. , Jan. 17, 2017 /PRNewswire/ ... today announced that it has initiated a global ... PTG-100, an oral peptide that targets alpha4beta7 integrin. ... design study is to evaluate the safety/tolerability and ... colitis patients with moderate to severe active disease. ...
Breaking Biology Technology: