Navigation Links
Improved estrogen reception may sharpen fuzzy memory
Date:7/29/2008

maintain health and counteract stress," Foster said. "We wanted to come back and enhance the signaling pathway that makes estrogen functional. We used a gene therapy technique that enables us to target the brain, but ultimately there could be a pharmaceutical that enhances the signaling pathway solely in the brain."

The mice had unusually low levels of estrogen because their ovaries were removed at an early age. However, scientists were still able to rescue learning ability by delivering the correct gene to produce estrogen receptor-alpha directly to the hippocampus.

Mice that lacked the estrogen receptor showed poor ability to locate a platform hidden in a small swimming tank over a training period of several days. After receiving the gene, the mice learned to locate the platform in two days of training.

"This research shows that when the estrogen receptor-alpha is restored to adult mice that have been missing it their entire lives, it is still possible to enhance memory and learning," said John H. Morrison, Ph.D., dean of basic sciences and the Graduate School of Biological Sciences at Mount Sinai School of Medicine, who did not participate in the research. "This is good news for moving forward to develop clinical interventions and therapeutics because it appears critical damage was not done to brain circuitry during early development. There has also been debate about which of at least two estrogen receptors is key to synaptic health. Clearly estrogen receptor-alpha plays a critically important role in hippocampal organization and function."

Recordings made from the brain tissue of treated mice showed signals were strongly communicated across the gaps, or synapses, between hippocampal cells, similar to what would happen with estrogen replacement.

"Investigating the impact of genetically replacing the estrogen receptor at the cellular, synaptic and behavioral levels is a scientific tour de force which provides a strong
'/>"/>

Contact: John Pastor
jdpastor@ufl.edu
352-273-5815
University of Florida
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Mobilizing white blood cells to the lung: New discovery could lead to an improved influenza vaccine
2. UF researchers develop improved gene therapy agent
3. Lean and mean biomass-degrading fungus reveals capabilities for improved biofuel production
4. Brain study may lead to improved epilepsy treatments
5. Chesapeake Bay ecosystem health remains poor, but slightly improved in 2007
6. Improved foam for varicose veins found to be safe in preliminary results from phase II trial
7. Physician-scientist urges improved drug regulation to ensure heart safety of non-heart drugs
8. UCR researchers awarded nearly $1.7M to develop improved cowpea varieties
9. In-vitro fertilization improved with 3-D/4-D-guided embryo transfer and new placement target
10. Improved e-jet printing provides higher resolution and more versatility
11. Estrogen helps drive distinct, aggressive form of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/15/2014)... for nearly all life on Earth, yet many aspects ... is known about how it is regulated in response ... not know the full list of the parts of ... , , A type of single-cell green algae called ... photosynthesis research. Despite its importance in the research world, ...
(Date:4/15/2014)... early as 2020 how high sea levels will rise ... researchers including Florida International University scientist Rene Price. , ... (NSF) Florida Coastal Everglades Long-Term Ecological Research (LTER) site, ... from coral reefs to deserts, mountains to salt marshes ... rise is one of the most certain consequences of ...
(Date:4/15/2014)... previously shown that a genetic pre-disposition to be more ... study, Frank Booth, a professor in the MU College ... the genetic pre-disposition for high levels of exercise motivation ... For his study, Booth selectively bred rats that exhibited ... then put the rats in cages with running wheels ...
Breaking Biology News(10 mins):Long-term predictions for Miami sea level rise could be available relatively soon 2Genetic pre-disposition toward exercise and mental development may be linked 2
... between a gene involved in vitamin D metabolism and skin ... CANCER , a peer-reviewed journal of the American Cancer Society, ... vitamin D-related gene, called BsmI, may be at an increased ... D in the body has significant protective effects against the ...
... of Minnesota College of Veterinary Medicine have identified a gene ... exercise-induced collapse (EIC). After intense hunting or retrieving exercise, activities ... lose control of their hind limbs. In most cases, ... in rare cases the dogs may die. Labradors are ...
... Two professors at Cold Spring Harbor Laboratory (CSHL) have ... of proteins that enable genes to express themselves in ... Michael Q. Zhang, Ph.D. and Adrian R. Krainer, ... are exploring a phenomenon that biologists and geneticists call ...
Cached Biology News:Variant of vitamin D receptor gene linked to melanoma risk 2U of M researchers identify gene linked to common ailment in labrador retrievers 2CSHL team traces extensive networks regulating alternative RNA splicing 2CSHL team traces extensive networks regulating alternative RNA splicing 3CSHL team traces extensive networks regulating alternative RNA splicing 4
(Date:1/15/2014)... 2014 This webinar will focus ... and clinical safety assessment in biosimilars. , Regulatory ... path for biosimilar drug development, however the complex ... with regards to quality, safety and efficacy extremely ... drug development and registration, development strategies differ significantly ...
(Date:1/15/2014)... DTS Language Services, Inc . is pleased ... for Life Science organizations who need document translations. ... subject matter of their documents in advance with a ... help reduce time-to-delivery of translations, often a critical factor ... of error. , “All translations are inherently time-sensitive by ...
(Date:1/14/2014)... 14, 2014 Date: Friday, April 11, ... Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... only national nonprofit organization solely dedicated to finding a ... life for those affected worldwide, will host its annual ... Club in Warrington, Pa. , Each year, the ...
(Date:1/14/2014)... York, NY (PRWEB) January 14, 2014 ... initiated coverage of Alliqua, Inc. (OTCQB: ALQA). Alliqua ... and marketing proprietary products to serve the wound ... , In late 2012, Alliqua was restructured ... launched the company’s new strategy to become a ...
Breaking Biology Technology:Xtalks Life Sciences Webinar Examines Safety Assessment of Biosimilars 2DTS Improves Efficiency for Life Science Document Translations 2Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3
... Borough ... Challenge. , ... (Vocus) March 12, 2010 -- Borough of Manhattan Community College (BMCC) science major ... Science Challenge—as well as $5,000 as an overall Grand Prizewinner., , , , ,Thompson--the contest,s ...
... ... , ... ... SEATTLE, WA , March 12 /PRNewswire-FirstCall/ - Oncothyreon Inc. (Nasdaq: ONTY ) today announced that it will restate its ...
... , THOUSAND OAKS, Calif. , March 11 Bone Biologics, Inc. announced today that it has received a US Patent Office Notice ... of the NELL 1 (UCB-1) protein by several delivery agents. , ... , ... ...
Cached Biology Technology:BMCC Student—the Only Community College Winner—Lands Grand Prize in Nobel Science Challenge 2Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 2Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 3Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 4Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 5Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 6Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 7Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 8Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 9Oncothyreon consults with Division of Corporation Finance about accounting for 2008 License Agreement 10Bone Biologics Announces a Major US Patent Issuance For Its Recombinant Protein Process For the Formation of Cartilage 2Bone Biologics Announces a Major US Patent Issuance For Its Recombinant Protein Process For the Formation of Cartilage 3
... analysis software with the DeCypher Engine accelerator cards ... can perform searches like these from your desktop: ... in under 6 days Align BAC-sized ... Use HMM analysis to compare 100,000 sequences to ...
Mouse monoclonal antibody to FMN2 - formin 2...
Rabbit polyclonal to SMARCA2 / BRM - ChIP Grade ( Abpromise for all tested applications). entrezGeneID: 6595 SwissProtID: P51531...
Mouse monoclonal [CAT-2] to Chloramphenicol Acetyltransferase...
Biology Products: